Decoy Receptor 1
Decoy receptor 1 (DcR1, TNFRSF10C, also TRAIL-R3 or CD263) is a glycophospholipid-anchored membrane protein of the TNF receptor superfamily that binds the apoptosis-inducing ligand TRAIL (TNFSF10) yet is structurally incapable of transducing the death signal. DcR1 possesses the characteristic extracellular cysteine-rich domains required for TRAIL binding but lacks both the transmembrane segment-containing death domain and any cytoplasmic region: it is tethered to the cell surface via a glycosylphosphatidylinositol (GPI) anchor, and it cannot oligomerize the death-inducing signaling complex. Consequently, DcR1 functions as an anti-apoptotic decoy, sequestering TRAIL away from the death receptors TRAIL-R1 (DR4) and TRAIL-R2 (DR5) and thereby protecting normal cells, particularly certain endothelial, epithelial and hematopoietic cells, from TRAIL-mediated killing. Many tumors overexpress DcR1 alongside DcR2 as an immune-evasion mechanism, conferring resistance to TRAIL-based therapy; promoter methylation silencing of DcR1 in some cancers conversely restores TRAIL sensitivity.
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Decoy Receptor 1 Recombinant Proteins (3)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
