2. Others Apoptosis
  3. Drug Derivative Apoptosis Bcl-2 Family Caspase IAP
  4. PZ-11

PZ-11 is a derivative of thiazolidinedione with anti-tumor activity. PZ-11 can induce cancer cells apoptosis by downregulating anti-apoptotic gene AIFM1, BAG3 and BIRC3 and regulating pro-apoptotic gene BAD, HRK, CASP10 and CASP10. PZ-11 can be used for research of breast cancer.

For research use only. We do not sell to patients.

PZ-11

PZ-11 Chemical Structure

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PZ-11 Related Antibodies

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cIAP cIAP-1 cIAP-2 XIAP

  • Biological Activity

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Description

PZ-11 is a derivative of thiazolidinedione with anti-tumor activity. PZ-11 can induce cancer cells apoptosis by downregulating anti-apoptotic gene AIFM1, BAG3 and BIRC3 and regulating pro-apoptotic gene BAD, HRK, CASP10 and CASP10. PZ-11 can be used for research of breast cancer[1].

IC50 & Target[1]

bad

 

Caspase-10

 

caspase 14

 

BIRC3

 

HRK

 

In Vitro

PZ-11 shows an IC50 of 17.35 μM against MCF-7 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PZ-11 Related Antibodies
Molecular Weight

402.81

Formula

C18H11ClN2O5S
SMILES

ClC1=CC=C(/C=C2SC(N(CC(C3=CC=CC([N+]([O-])=O)=C3)=O)C/2=O)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PZ-11 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PZ-11PZ11PZ 11Drug DerivativeApoptosisBcl-2 FamilyCaspaseIAPDrug derivativeInhibitorinhibitorinhibit

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