1. Signaling Pathways
  2. Apoptosis
  3. Bcl-2 Family
  4. Bcl-2 Inhibitors

Bcl-2 Inhibitors

Bcl-2

Bcl-xL

Bcl-W

Mcl-1

Bfl-1

Bcl-B

Bax

Bak

Bim

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Sorry. There is currently no product that acts on isoform Bcl-2 together.

Please try each isoform separately.

Bcl-2 Specific Inhibitors, Antagonists, Activators & Modulators
Product Name Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim Bcl-2 Selectivity Purity
Venetoclax
Bcl-2, Ki: 0.01 nM
Bcl-xL, Ki: 48 nM
Bcl-W, Ki: 245 nM
            Selective Inhibitor 99.95%
S55746
Bcl-2, Ki: 1.3 nM
Bcl-2, Kd: 3.9 nM
Bcl-xL, Ki: 520 nM
Bcl-xL, Kd: 186 nM
              Selective Inhibitor 98.97%
Bcl-2-IN-2
Bcl-2, IC50: 0.034 nM
Bcl-xL, IC50: 43 nM
              Selective Inhibitor
Navitoclax
Bcl-2, Ki: 1 nM
Bcl-xL, Ki: 1 nM
Bcl-W, Ki: 1 nM
            Pan Inhibitor 99.97%
ABT-737
Bcl-2, EC50: 30.3 nM
Bcl-xL, EC50: 78.7 nM
Bcl-W, EC50: 197.8 nM
   
Bcl-B, EC50: 1820 nM
      Pan Inhibitor 99.59%
A-1331852
Bcl-2, Ki: 6 nM
Bcl-xL, Ki: 0.01 nM
Bcl-W, Ki: 4 nM
Mcl-1, Ki: 142 nM
          Pan Inhibitor 99.81%
Obatoclax Mesylate
Bcl-2, Ki: 220 nM
Bcl-xL, Ki: 1-7 μM
Bcl-W, Ki: 1-7 μM
Mcl-1, Ki: 1-7 μM
 
Bcl-B, Ki: 1-7 μM
      Pan Inhibitor 99.74%
A-1155463
Bcl-2, Ki: 80 nM
Bcl-xL, Ki: 0.01 nM
              Pan Inhibitor 99.62%
A-1210477
Bcl-2, Ki: 132 nM
 
Bcl-W, Ki: 2280 nM
Mcl-1, Ki: 0.45 nM
Bfl-1, Ki: 660 nM
        Pan Inhibitor 98.89%
Gossypol (acetic acid)
Bcl-2, Ki: 0.2-0.3 mM
Bcl-xL, Ki: 0.5-0.6 μM
              Pan Inhibitor 99.41%
Gambogic Acid
Bcl-2, IC50: 1.21 μM
Bcl-xL, IC50: 1.47 μM
Bcl-W, IC50: 2.02 μM
Mcl-1, IC50: 0.79 μM
Bfl-1, IC50: 1.06 μM
Bcl-B, IC50: 0.66 μM
      Pan Inhibitor 95.06%
Glycocholic acid
Bcl-2
         
Bax
    Pan >98.0%
TW-37
Bcl-2, Ki: 290 nM
Bcl-xL, Ki: 1110 nM
 
Mcl-1, Ki: 260 nM
          Pan Inhibitor 98.50%
PROTAC Bcl2 degrader-1
Bcl-2, DC50: 3 μM
Bcl-2, IC50: 4.94 μM
   
Mcl-1, IC50: 11.81 μM
          Pan Inhibitor 98.28%
(R)-(-)-Gossypol acetic acid
Bcl-2, Ki: 260 nM
Bcl-xL, Ki: 480 nM
 
Mcl-1, Ki: 170 nM
          Pan Inhibitor 97.40%
Gossypol
Bcl-2, Ki: 0.2-0.3 mM
Bcl-xL, Ki: 0.5-0.6 μM
              Pan Antagonist 99.03%
A-385358
Bcl-2, Ki: 67 nM
Bcl-xL, Ki: 0.8 nM
              Pan Inhibitor 99.05%
Dehydrocorydaline
Bcl-2
         
Bax
    Pan Modulator 99.01%
HA14-1
Bcl-2, IC50: 9 μM
                Pan Inhibitor >98.0%
BH3I-1
Bcl-2
Bcl-xL
         
Bak
Bim
Pan Inhibitor >98.0%
Thevetiaflavone
Bcl-2
         
Bax
    Pan Modulator
AZD4320
BCL2, IC50: 17 nM (KPUM-UH1 cells)
BCLxL, IC50: 17 nM (KPUM-UH1 cells)
              Pan Inhibitor 99.10%
Paris saponin VII
Bcl-2
                Pan Inhibitor >99.0%
(R)-(-)-Gossypol
Bcl-2, Ki: 260 nM
Bcl-xL, Ki: 480 nM
 
Mcl-1, Ki: 170 nM
          Pan Inhibitor
(S)-Gossypol acetic acid
Bcl-2
Bcl-xL
              Pan Inhibitor >98.0%
Sabutoclax
BCL2, IC50: 0.32 μM
Bcl-xL, IC50: 0.31 μM
 
Mcl-1, IC50: 0.2 μM
Bfl-1, IC50: 0.62 μM
        Pan Inhibitor
Obatoclax
BCL2, Ki: 200 nM
Bcl-xL, Ki: 1-7 μM
Bcl-W, Ki: 1-7 μM
Mcl-1, Ki: 1-7 μM
 
Bcl-B, Ki: 1-7 μM
      Pan Inhibitor
MCL-1/BCL-2-IN-1
Bcl-2, IC50: 3.18 μM
   
Mcl-1, IC50: 4.45 μM
          Pan Inhibitor 98.04%
TCPOBOP
Bcl-2
                Pan Inhibitor
BM 957
Bcl-2, IC50: 5.4 nM
Bcl-2, Ki: 1.2 nM
Bcl-xL, IC50: 6.0 nM
Bcl-xL, Ki: <1 nM
              Pan Inhibitor
Destruxin B
Bcl-2
                Pan Activator
(+)-Apogossypol
Bcl-2, EC50: 2.8 μM
Bcl-xL, EC50: 3.69 μM
 
Mcl-1, EC50: 2.6 μM
          Pan Inhibitor