1. Signaling Pathways
  2. Apoptosis
  3. Bcl-2 Family
  4. Bcl-2 Isoform

Bcl-2

 

Bcl-2 Related Products (66):

Cat. No. Product Name Effect Purity
  • HY-15531
    Venetoclax
    Inhibitor 99.78%
    Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a Ki of less than 0.01 nM.
  • HY-10087
    Navitoclax
    Inhibitor 99.97%
    Navitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-xL, Bcl-2 and Bcl-w, with a Ki of less than 1 nM.
  • HY-50907
    ABT-737
    Inhibitor 99.59%
    ABT-737, a BH3 mimetic, is a potent Bcl-2, Bcl-xL and Bcl-w inhibitor with EC50s of 30.3 nM, 78.7 nM, and 197.8 nM, respectively.
  • HY-19741
    A-1331852
    Inhibitor 99.65%
    A-1331852 is an orally available BCL-XL selective inhibitor with a Ki of less than 10 pM.
  • HY-19725
    A-1155463
    Inhibitor 99.51%
    A-1155463 is a highly potent and selective BCL-XL inhibitor with an EC50 of 70 nM in Molt-4 cell.
  • HY-N9802
    n-Butyl-β-D-fructofuranoside
    Activator
    n-Butyl-β-D-fructofuranoside could be isolated from kangaisan.
  • HY-W082785A
    L6H21
    Modulator
    L6H21, a Chalcone (HY-121054) derivative, is an orally active, potent and specific myeloid differentiation 2 (MD-2) inhibitor.
  • HY-19551
    Apogossypolone
    Inhibitor
    Apogossypolone (ApoG2) is an orally active Bcl-2 family proteins inhibitor with Ki values of 35, 25 and 660 nM for Bcl-2, Mcl-1 and Bcl-XL, respectively.
  • HY-112416
    AZD4320
    Inhibitor 99.68%
    AZD4320 is a novel BH3-mimicking dual BCL2/BCLxL inhibitor with IC50s of 26 nM, 17 nM, and 170 nM for KPUM-MS3, KPUM-UH1, and STR-428 cells, respectively.
  • HY-10969
    Obatoclax Mesylate
    Inhibitor 99.74%
    Obatoclax Mesylate (GX15-070 Mesylate), a BH3 mimetic, is a pan-BCL-2 family proteins inhibitor with a Ki of 220 nM for BCL-2.
  • HY-N0674
    Dehydrocorydaline
    Modulator 99.77%
    Dehydrocorydaline (13-Methylpalmatine) is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP.
  • HY-12468
    A-1210477
    Inhibitor 98.89%
    A-1210477 is a potent and selective inhibitor of MCL-1 with a Ki of 0.45 nM.
  • HY-N0087
    Gambogic Acid
    Inhibitor 98.85%
    Gambogic Acid (Beta-Guttiferrin) is derived from the gamboges resin of the tree Garcinia hanburyi.
  • HY-B0402A
    Amantadine hydrochloride
    Modulator ≥98.0%
    Amantadine (1-Adamantanamine) hydrochloride is an orally avtive and potent antiviral agent with activity against influenza A viruses.
  • HY-103243
    TCPOBOP
    Inhibitor 98.07%
    TCPOBOP is a constitutive androstane receptor (CAR) agonist that induces robust hepatocyte proliferation and hepatomegaly without any liver injury or tissue loss.
  • HY-15464A
    (R)-(-)-Gossypol acetic acid
    Inhibitor 98.02%
    (R)-(-)-Gossypol acetic acid (AT-101 (acetic acid)) is the levorotatory isomer of a natural product Gossypol.
  • HY-13407
    Gossypol
    Antagonist 99.56%
    Gossypol binds to Bcl-xL protein and Bcl-2 protein with Kis of 0.5-0.6 μM and 0.2-0.3 mM, respectively.
  • HY-117288
    S55746
    Inhibitor 99.66%
    S55746 (BCL201) is a potent, orally active and selective BCL-2 inhibitor, with a Ki of 1.3 nM and a Kd of 3.9 nM.
  • HY-125877
    PROTAC Mcl1 degrader-1
    Inhibitor 98.13%
    PROTAC Mcl1 degrader-1 (compound C3), a proteolysis targeting chimera (PROTAC) based on Cereblon ligand, is a potently and selectively Mcl-1 (Bcl-2 family member) inhibitor with an IC50 of 0.78 μM.
  • HY-17510
    Gossypol (acetic acid)
    Inhibitor 99.17%
    Gossypol acetic acid ((±)-Gossypol-acetic acid) binds to Bcl-xL protein and Bcl-2 protein with Kis of 0.5-0.6 μM and 0.2-0.3 mM, respectively.