1. Membrane Transporter/Ion Channel
  2. Na+/K+ ATPase

Digitoxin 

Cat. No.: HY-B1357 Purity: 98.23%
Handling Instructions

Digitoxin is an effective Na+/K+-ATPase inhibitor, the EC50 value of Digitoxin is 0.78 μM.

For research use only. We do not sell to patients.
Digitoxin Chemical Structure

Digitoxin Chemical Structure

CAS No. : 71-63-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 101 In-stock
5 mg USD 60 In-stock
10 mg   Get quote  
50 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Digitoxin is an effective Na+/K+-ATPase inhibitor, the EC50 value of Digitoxin is 0.78 μM. IC50 value: 0.78 μM (EC50) Target: Na+/K+-ATPase in vitro: Digitoxin shows a significantly cytotoxic effect in H1975 cells by causing G2 phase arrest, also remarkably activates 5' adenosine monophosphate-activated protein kinase (AMPK). Moreover, Digitoxin suppresses microtubule formation through decreasing α-tubulin. Digitoxin effectively depresses the growth of TKI-resistance NSCLC H1975 cells by inhibiting microtubule polymerization and inducing cell cycle arrest. Digitoxin has the highest cytotoxicity in H1975 cells, whose CC50 value was 0.19 ± 0.06 μM. Digitoxin-induced inhibition mechanism is likely due to causing G2/M cell cycle arrest in H1975 cells in dose dependent manners.

Clinical Trial
References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 1.3073 mL 6.5365 mL 13.0729 mL
5 mM 0.2615 mL 1.3073 mL 2.6146 mL
10 mM 0.1307 mL 0.6536 mL 1.3073 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

764.94

Formula

C₄₁H₆₄O₁₃

CAS No.

71-63-6

SMILES

C[[email protected]]1O[[email protected]](O[[email protected]@H]2[[email protected]@H](C)O[[email protected]](O[[email protected]]3[[email protected]@H](O)C[[email protected]@](O[[email protected]@H]4C[[email protected]](CC[[email protected]]5([H])[[email protected]]6([H])CC[[email protected]@]7(C)[[email protected]]5(O)CC[[email protected]@H]7C(CO8)=CC8=O)([H])[[email protected]]6(C)CC4)([H])O[[email protected]@H]3C)([H])C[[email protected]@H]2O)([H])C[[email protected]](O)[[email protected]@H]1O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Digitoxin
Cat. No.:
HY-B1357
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