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ovcar-3-cell

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By Targets:	Akt (2) Amyloid-β (2) Apoptosis (5) Bacterial (1) COX (2) Drug Derivative (1) Fungal (1) Kinesin (2) Microtubule/Tubulin (1) mTOR (2) NO Synthase (2) p38 MAPK (2) Parasite (1) PI3K (2) Reactive Oxygen Species (ROS) (2) Reference Standards (1) Toll-like Receptor (TLR) (2) Wee1 (1)
By Research Areas:	Cancer (9) Infection (1) Inflammation/Immunology (2) Metabolic Disease (2) Neurological Disease (2)

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Natural
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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0022

Isoacteoside 5+ Cited Publications Isoverbascoside	Apoptosis Reactive Oxygen Species (ROS) Akt mTOR PI3K NO Synthase COX p38 MAPK Toll-like Receptor (TLR) Amyloid-β	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Isoacteoside is a natural product that can significantly inhibit the formation of glycation end products. Isoacteoside regulates the *AKT/PI3K/m-TOR/NF-κB* signaling pathway, induces apoptosis in OVCAR-3 cell. Isoacteoside exhibits antitumor, anti-inflammatory, anti-obesity and neuroprotective activities ^[3] .

HY-N10544

δ-Cadinene (+)-δ-Cadinene	Bacterial Parasite Fungal Apoptosis	Infection Cancer
δ-Cadinene ((+)-δ-Cadinene) is a sesquiterpene in essential oils. δ-Cadinene shows antiproliferative and pro-apoptotic effects on human ovary cancer (OVCAR-3) cells. δ-Cadinene has trichomonacidal, antimicrobial, antifungal and anticancer properties .

HY-175819

PD-166285	Wee1 Apoptosis	Cancer
PD-166285 is a PKMYT1 inhibitor, with an IC₅₀ value of 17 nM. PD166285 shows strong antiproliferative effects against CCNE1-amplified OVCAR3 cells (IC₅₀ = 0.14 μM) and HCC1569 cells (IC₅₀ = 0.21 μM). PD166285 induces apoptosis and arrests CCNE1-amplified HCC1569 cells at the G1/S phase of the cell cycle. PD166285 can be used for the research of PKMYT1-targeted therapies for CCNE1-amplified cancers .

HY-N0022R

Isoacteoside (Standard) Isoverbascoside (Standard)	Toll-like Receptor (TLR) Amyloid-β Reference Standards Apoptosis Reactive Oxygen Species (ROS) Akt mTOR PI3K NO Synthase COX p38 MAPK	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Isoacteoside (Standard) is the analytical standard of Isoacteoside. This product is intended for research and analytical applications. Isoacteoside is a natural product that can significantly inhibit the formation of glycation end products. Isoacteoside Standard regulates the *AKT/PI3K/m-TOR/NF-κB* signaling pathway, induces apoptosis in OVCAR-3 cell. Isoacteoside Standard exhibits antitumor, anti-inflammatory, anti-obesity and neuroprotective activities .

HY-N7760

Neosalvianen	Others	Others
Neosalvianen is a N-containing compound that shows cytotoxic activities against the HeLa, HepG2, and OVCAR-3 cell lines, with IC₅₀ of 63.9 µM, 59.2 µM, and 74.6 µM, respectively .

HY-N10268

3-Hydroxyterphenyllin NSC 299113	Apoptosis	Cancer
3-Hydroxyterphenyllin is a metabolite of Aspergillus candidus.3-Hydroxyterphenyllin suppresses proliferation and causes cytotoxicity against A2780/CP70 and OVCAR-3 cells. 3-Hydroxyterphenyllin induces S phase arrest and apoptosis. 3-Hydroxyterphenyllin has the potential for the research of ovarian cancer .

HY-169476

Pyrrolidine linoleamide	Drug Derivative	Cancer
Pyrrolidine linoleamide is a derivative of linoleic acid amide with anticancer activity. Pyrrolidine linoleamide exhibits antiproliferative activity against a range of cancer cell lines, with IC₅₀ values of 12.0, 27.5, 7.7, 21.9, 36.6, 32.6, and 33.9 μg/mL against U251, MCF-7, NCI-ADR/RES, 786-0, NCI-H460, PC-3, and OVCAR-3 cell lines, respectively .

HY-164978

KIF18A-IN-14	Kinesin	Cancer
KIF18A-IN-14 (Compound Example 81) is a KIF18A inhibitor. KIF18A-IN-14 is available in two forms, EX81-A and its enantiomer EX81-B. EX81-A and EX81-B inhibit OVCAR-3 cells viability with IC₅₀s of 0-0.01 μM and 0.01-0.1 μM, respectively. KIF18A-IN-14 can be used in tumor (e.g. colon, breast, lung) studies .

HY-164979

KIF18A-IN-15	Kinesin	Cancer
KIF18A-IN-15 (Compound Example 36) is a KIF18A inhibitor, available in two forms, EX36-A and its enantiomer EX36-B, with IC₅₀s of 0.01-0.1 μM, respectively. EX36-A and EX36-B inhibit OVCAR-3 cells viability with IC₅₀s of 0.01-0.1 μM and 0-0.01 μM, respectively. KIF18A-IN-15 can be used in tumor (e.g. colon, breast, lung) studies .

HY-N16507

Bruceoside D	Microtubule/Tubulin	Cancer
Bruceoside D is a cytotoxic quassinoid glucoside found in Brucea javanica. Bruceoside D is a microtubule polymerization inhibitor. Bruceoside D demonstrates inhibitory activity against leukemia (CCRF-CEM), non-small cell lung cancer (A549), and ovarian cancer (OVCAR-3) cell lines. Bruceoside D is promising for research of cancers .

Isoacteoside 5+ Cited Publications Isoverbascoside	Classification of Application Fields Simple Phenylpropanols Cistanche deserticola Ma Phenols Polyphenols Orobanchaceae Metabolic Disease Phenylpropanoids Plants Disease Research Fields Source Classification	Apoptosis Reactive Oxygen Species (ROS) Akt mTOR PI3K NO Synthase COX p38 MAPK Toll-like Receptor (TLR) Amyloid-β
Isoacteoside is a natural product that can significantly inhibit the formation of glycation end products. Isoacteoside regulates the *AKT/PI3K/m-TOR/NF-κB* signaling pathway, induces apoptosis in OVCAR-3 cell. Isoacteoside exhibits antitumor, anti-inflammatory, anti-obesity and neuroprotective activities ^[3] .

δ-Cadinene (+)-δ-Cadinene	Structural Classification Terpenoids Labiatae Sesquiterpenes Plants Medicago sativa L.	Bacterial Parasite Fungal Apoptosis
δ-Cadinene ((+)-δ-Cadinene) is a sesquiterpene in essential oils. δ-Cadinene shows antiproliferative and pro-apoptotic effects on human ovary cancer (OVCAR-3) cells. δ-Cadinene has trichomonacidal, antimicrobial, antifungal and anticancer properties .

Isoacteoside (Standard) Isoverbascoside (Standard)	Structural Classification Simple Phenylpropanols Cistanche deserticola Ma Phenols Polyphenols Orobanchaceae Phenylpropanoids Plants Source Classification	Toll-like Receptor (TLR) Amyloid-β Reference Standards Apoptosis Reactive Oxygen Species (ROS) Akt mTOR PI3K NO Synthase COX p38 MAPK
Isoacteoside (Standard) is the analytical standard of Isoacteoside. This product is intended for research and analytical applications. Isoacteoside is a natural product that can significantly inhibit the formation of glycation end products. Isoacteoside Standard regulates the *AKT/PI3K/m-TOR/NF-κB* signaling pathway, induces apoptosis in OVCAR-3 cell. Isoacteoside Standard exhibits antitumor, anti-inflammatory, anti-obesity and neuroprotective activities .

Neosalvianen	Alkaloids Terpenoids Other Alkaloids Labiatae Samanea saman (Jacq.) Merr. Diterpenoids Plants Source Classification	Others
Neosalvianen is a N-containing compound that shows cytotoxic activities against the HeLa, HepG2, and OVCAR-3 cell lines, with IC₅₀ of 63.9 µM, 59.2 µM, and 74.6 µM, respectively .

3-Hydroxyterphenyllin NSC 299113	Microorganisms Classification of Application Fields Phenols Polyphenols Disease Research Fields Cancer Source Classification	Apoptosis
3-Hydroxyterphenyllin is a metabolite of Aspergillus candidus.3-Hydroxyterphenyllin suppresses proliferation and causes cytotoxicity against A2780/CP70 and OVCAR-3 cells. 3-Hydroxyterphenyllin induces S phase arrest and apoptosis. 3-Hydroxyterphenyllin has the potential for the research of ovarian cancer .

Bruceoside D	Structural Classification Natural Products Simaroubaceae Plants Brucea javanica (L.) Merr. Source Classification	Microtubule/Tubulin
Bruceoside D is a cytotoxic quassinoid glucoside found in Brucea javanica. Bruceoside D is a microtubule polymerization inhibitor. Bruceoside D demonstrates inhibitory activity against leukemia (CCRF-CEM), non-small cell lung cancer (A549), and ovarian cancer (OVCAR-3) cell lines. Bruceoside D is promising for research of cancers .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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ovcar-3-cell

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