1. Natural Products
  2. Alkaloids

Alkaloids

Alkaloids are a group of naturally occurring chemical compounds that mostly contain basic nitrogen atoms, produced by a large variety of organisms including bacteria, fungi, plants, and animals. Compounds like amino acid peptides, proteins, nucleotides, nucleic acid, amines, and antibiotics are usually not called alkaloids. They are classified on the basis of the principal C-N skeleton structure which includes numerous subclasses of alkaloids namely, pyrrole, pyridine, quinoline, isoquinoline, indole and other alkaloids, etc. Alkaloids have a wide range of pharmacological activities including antimalarial, anti-asthmatic, anti-cancer, cholinomimetic, vasodilating, anti-arrhythmic, analgesic, anti-bacterial, and anti-diabetic activities. Many have found use in traditional or modern medicine, or as starting points for drug discovery. They possess potent pharmacological effects for eg. the well-known plant alkaloids include the narcotic analgesics, morphine and codeine, the muscle relaxant papaverine, and the antimicrobial agents sanguinarine and berberine. And some alkaloids are toxic.

Alkaloids (803):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-15141
    Staurosporine 62996-74-1 99.98%
    Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases with IC50s of 6 nM, 15 nM, 2 nM, and 3 nM for PKC, PKA, c-Fgr, and Phosphorylase kinase respectively. Staurosporine also inhibits TAOK2 with an IC50 of 3 μM. Staurosporine is an apoptosis inducer.
    Staurosporine
  • HY-A0190
    Ceruletide 17650-98-5 99.96%
    Ceruletide is a decapeptide and a potent cholecystokinin receptor agonist. Ceruletide is a safe and effective cholecystokinetic agent with a direct spasmogenic effect on the gallbladder muscle and bile ducts.
    Ceruletide
  • HY-13704
    SN-38 86639-52-3 99.80%
    SN-38 (NK012) is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 (NK012) inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively.
    SN-38
  • HY-N0488
    Vincristine sulfate 2068-78-2 99.81%
    Vincristine sulfate is an antitumor vinca alkaloid which inhibits microtubule formation in mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. It binds to microtubule with a Ki of 85 nM.
    Vincristine sulfate
  • HY-16560
    Camptothecin 7689-03-4 99.69%
    Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM. Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells.
    Camptothecin
  • HY-N0716B
    Berberine sulfate 633-66-9 ≥98.0%
    Berberine sulfate is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine sulfate induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Berberine sulfate has antineoplastic properties.
    Berberine sulfate
  • HY-13626
    Spisulosine 196497-48-0 ≥98.0%
    Spisulosine (ES-285) is an antiproliferative (antitumoral) compound of marine origin. Spisulosine inhibits the growth of the prostate PC-3 and LNCaP cells through intracellular ceramide accumulation and PKCζ activation.
    Spisulosine
  • HY-119529
    Jineol 178762-28-2 99.11%
    Jineol is a cytotoxic alkaloid from the centipede Scolopendra subspinipes. Jineol exhibits modest cytotoxic activity in vitro against the growth of human tumor cell lines.
    Jineol
  • HY-123033A
    Nicotinamide riboside chloride 23111-00-4 99.53%
    Nicotinamide riboside Chloride, an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3. Nicotinamide riboside Chloride is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside Chloride reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease.
    Nicotinamide riboside chloride
  • HY-N0750
    Monocrotaline 315-22-0 98.08%
    Monocrotaline is an pyrrolizidine alkaloid extracted from the seeds of the Crotalaria spectabilis plant to induce pulmonary hypertension in rodents.
    Monocrotaline
  • HY-B0726
    Pilocarpine Hydrochloride 54-71-7 99.98%
    Pilocarpine Hydrochloride is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.
    Pilocarpine Hydrochloride
  • HY-18258
    Berberine chloride 633-65-8 99.66%
    Berberine chloride is an alkaloid that acts as an antibiotic. Berberine chloride induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties.
    Berberine chloride
  • HY-B0573
    Propranolol hydrochloride 318-98-9 99.79%
    Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively. Propranolol hydrochloride inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM. Propranolol hydrochloride is used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy.
    Propranolol hydrochloride
  • HY-N2309
    Kainic acid 487-79-6 ≥99.0%
    Kainic acid is a potent agonist at excitatory amino acid receptor subtypes in the CNS.
    Kainic acid
  • HY-16562A
    Irinotecan hydrochloride 100286-90-6 99.75%
    Irinotecan hydrochloride ((+)-Irinotecan hydrochloride) is a topoisomerase I inhibitor mainly used to treat colon cancer and rectal cancer.
    Irinotecan hydrochloride
  • HY-N0219
    Bicuculline 485-49-4 99.97%
    Bicuculline ((+)-Bicuculline; d-Bicuculline), as a convulsant alkaloid, is a competitive neurotransmitter GABAA receptor antagonist (IC50=2 μM). Bicuculline also blocks Ca2+-activated potassium (SK) channels and subsequently blocks the slow afterhyperpolarization (slow AHP) .
    Bicuculline
  • HY-17024
    Cyclopamine 4449-51-8 99.97%
    Cyclopamine is a Hedgehog (Hh) pathway antagonist with an IC50 of 46 nM in the Hh cell assay. Cyclopamine is also a selective Smo inhibitor.
    Cyclopamine
  • HY-19356
    Rocaglamide 84573-16-0 99.34%
    Rocaglamide (Roc-A) is isolated from the genus Aglaia and can be used for coughs, injuries, asthma and inflammatory skin diseases. Rocaglamide is a potent inhibitor of NF-κB activation in T-cells. Rocaglamide is a potent and selective heat shock factor 1 (HSF1) activation inhibitor with an IC50 of ~50 nM. Rocaglamide inhibits the function of the translation initiation factor eIF4A. Rocaglamide also has anticancer properties in leukemia.
    Rocaglamide
  • HY-14944
    Homoharringtonine 26833-87-4 99.65%
    Homoharringtonine (Omacetaxine mepesuccinate;HHT) is a cytotoxic alkaloid with antitumor properties which acts by inhibiting translation elongation.
    Homoharringtonine
  • HY-12053A
    Vinorelbine ditartrate 125317-39-7 98.08%
    Vinorelbine (ditartrate) is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC50 of 1.25 nM.
    Vinorelbine ditartrate