Imidazole Alkaloids

Imidazole-5-propionic acid (Imidazolepropionic acid) is a urinary metabolite of L-histidine (HY-N0832). Imidazole-5-propionic acid can be used in the research of intestinal diseases and cardiovascular diseases.

Naamidine J is an imidazole-type alkaloids discovered in a sponge. Naamidine J inhibits inflammation by binding to the protein CSE1L (K_D = 5.41 μM). Namidine J significantly inhibits the expression of pro-inflammatory factors such as TNF-α, IL-1β, and IL-6, and upregulates anti-inflammatory factors such as CD206 and Arg-1. Namidine J inhibits PD-L1 and shows antitumor activity. Namidine J significantly reduces pulmonary tissue edema, inflammatory cell infiltration and cytokine storm in mice. Namidine J can be used for the research on the immune microenvironment of acute lung injury and tumors.

Imidazole-4-pyruvic acid (Imidazolepyruvic acid) is a metabolic precursor for histidine synthesis and selective stable isotope labeling of histidine residues. Imidazole-4-pyruvic acid serves as a precursor for selective histidine labeling in overexpressed proteins of Escherichia coli. Imidazole-4-pyruvic acid can be used in studies related to cancer and fungal mold infections.

Imidazole-4-pyruvic acid TFA (Imidazolepyruvic acid TFA) is a metabolic precursor for histidine synthesis and selective stable isotope labeling of histidine residues. Imidazole-4-pyruvic acid TFA serves as a precursor for selective histidine labeling in overexpressed proteins of Escherichia coli. Imidazole-4-pyruvic acid TFA can be used in studies related to cancer and fungal mold infections.

1,3-Diacetyl-2-imidazolidinone is an imidazolidinone derivative. 1,3-Diacetyl-2-imidazolidinone can be found in the benzene/ethanol extractives of Eucalyptus urophylla leaves.

Thiourocanic acid is a product of the reaction between ergothionase and the ergothioneine substrate.

Indol-3-yl-acetothiohydroxamic acid is an intermediate in the biosynthesis of plant antitoxins.

4-Oxo-4,5-dihydroimidazole-5-acetic acid is a nucleoside metabolite.

Imidazole-5-propionic acid is a histidine metabolite.