2504-83-8
Chemical Structure
Imidazole-4-pyruvic acid
Synonym(s): Imidazolepyruvic acid; ImPA
- CAS No.: 2504-83-8
- Formula:C6H6N2O3
- Molecular Weight:154.12
InChIKey: JEJNWEREQWMOHB-UHFFFAOYSA-N
SMILES: O=C(C(CC1=CN=CN1)=O)O
Biological Activity: Imidazole-4-pyruvic acid (Imidazolepyruvic acid) is a metabolic precursor for histidine synthesis and selective stable isotope labeling of histidine residues. Imidazole-4-pyruvic acid serves as a precursor for selective histidine labeling in overexpressed proteins of Escherichia coli. Imidazole-4-pyruvic acid can be used in studies related to cancer and fungal mold infections[1][2][3][4].
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Imidazole-4-pyruvic acid | Imidazole-4-pyruvic acid (Imidazolepyruvic acid) is a metabolic precursor for histidine synthesis and selective stable isotope labeling of histidine residues. Imidazole-4-pyruvic acid serves as a precursor for selective histidine labeling in overexpressed proteins of Escherichia coli. Imidazole-4-pyruvic acid can be used in studies related to cancer and fungal mold infections. | |||||||||||||||||||||
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- [1]. Schörghuber J, et al. Highly Selective Stable Isotope Labeling of Histidine Residues by Using a Novel Precursor in E. coli-Based Overexpression Systems. Chembiochem : a European journal of chemical biology. 2017 Aug 04;18(15):1487-1491. [Content Brief]
- [2]. Brüschweiler S, et al. Isotopologues of a Metabolic Precursor for Selective N-15 and C-13 Histidine Labeling. J Mol Biol. 2025 Dec 1;437(23):169347.
- [3]. SIJPESTEYN AK, et al. Investigations on organic fungicides. IX. The antagonistic action of certain imidazole derivatives and of alpha-keto acids on the fungitoxicity of dimethyldithiocarbamates. Biochim Biophys Acta. 1954 Sep;15(1):69-77.
- [4]. Wadud S, et al. Studies on the possibility of histidine biosynthesis from histodinol, imidazolepyruvic acid, imidazoleacetica acid, and imidazolelactic acid by mixed ruminal bacteria, protozoa, and their mixture in vitro. Appl Microbiol Biotechnol. 2001 Mar;55(2):219-25.
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