Imidazole-5-propionic acid
Based on 1 publication(s) in Google Scholar
Imidazole-5-propionic acid (Imidazolepropionic acid) is a urinary metabolite of L-histidine (HY-N0832). Imidazole-5-propionic acid can be used in the research of intestinal diseases and cardiovascular diseases.
For research use only. We do not sell to patients.
- Purity: 99.99%
- CAS No.: 1074-59-5
- Formula: C6H8N2O2
- Molecular Weight:140.14
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Imidazole-5-propionic acid
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Customer Validation & Images
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Cell Proliferation/Viability Assay
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Cell Imaging/Staining
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Cell Migration/Invasion Assay
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In Vivo Efficacy Study
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Histological Imaging/Staining
All Endogenous Metabolite Isoforms
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Biological Activity
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Human Endogenous Metabolite |
Imidazole-5-propionic acid can be used in research on intestinal diseases[2].
Imidazole-5-propionic acid has emerged as a significant mediator linking gut microbiota dysbiosis to atherosclerosis and cardiovascular disease, or coronary artery disease (CAD)[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1074-59-5
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Appearance Solid
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Molecular Weight 140.14
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Formula C6H8N2O2
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Color Off-white to light yellow
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SMILES
C(CC(=O)O)C1=CN=CN1
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Synonyms
Imidazolepropionic acid
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Mol Med
Microbially produced imidazole propionate impairs prostate cancer progression through PDZK1. [Abstract]2025 Jan 16;31(1):14. PMID: 39819421
Imidazole-5-propionic acid purchased from MedChemExpress. Usage Cited in: Mol Med. 2025 Jan 16;31(1):14. [Abstract]
Imidazole-5-propionic acid (IMP) (2-12 mM; 24-48 h) significantly decreased the viability of PC3 and DU145 cells in a dose-dependent manner.
Imidazole-5-propionic acid purchased from MedChemExpress. Usage Cited in: Mol Med. 2025 Jan 16;31(1):14. [Abstract]
Imidazole-5-propionic acid (IMP) (5-10 mM) significantly reduced the number of EdU-stained cells in the PC3 and DU145 cell lines.
Imidazole-5-propionic acid purchased from MedChemExpress. Usage Cited in: Mol Med. 2025 Jan 16;31(1):14. [Abstract]
Imidazole-5-propionic acid (IMP) (1-10 mM) reduced the migratory ability of PC3 and DU145 cells.
Imidazole-5-propionic acid purchased from MedChemExpress. Usage Cited in: Mol Med. 2025 Jan 16;31(1):14. [Abstract]
Imidazole-5-propionic acid (IMP) (40 mg/mL; i.p.; twice a day) significantly reduced tumor volume and weight in subcutaneous xenograft mice.
Imidazole-5-propionic acid purchased from MedChemExpress. Usage Cited in: Mol Med. 2025 Jan 16;31(1):14. [Abstract]
Imidazole-5-propionic acid (IMP) (40 mg/mL; i.p.; twice a day) preserved tumor tissue structure, reduced Ki-67 expression, and increased PDZK1 expression in the tumor tissue of subcutaneous xenograft mice.
Solvent & Solubility
H2O : 100 mg/mL (713.57 mM; Need ultrasonic)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Wadud S, et al. In vitro catabolism of histidine by mixed rumen bacteria and protozoa. Curr Microbiol. 2001 Jan;42(1):12-7. [Content Brief]
[2]. van der Heiden C, et al. Increased urinary imidazolepropionic acid, N-acetylhistamine and other imidazole compounds in patients with intestinal disorders. Clin Chim Acta. 1972 Jun;39(1):201-14. [Content Brief]
[3]. Pinnelli VB, et al. The Role Played by Imidazole Propionic Acid in Modulating Gut-Heart Axis and the Development of Atherosclerosis: An Explorative Review. Cureus. 2025 Oct 11;17(10):e94362. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 7.1357 mL | 35.6786 mL | 71.3572 mL | 178.3930 mL |
| 5 mM | 1.4271 mL | 7.1357 mL | 14.2714 mL | 35.6786 mL | |
| 10 mM | 0.7136 mL | 3.5679 mL | 7.1357 mL | 17.8393 mL | |
| 15 mM | 0.4757 mL | 2.3786 mL | 4.7571 mL | 11.8929 mL | |
| 20 mM | 0.3568 mL | 1.7839 mL | 3.5679 mL | 8.9197 mL | |
| 25 mM | 0.2854 mL | 1.4271 mL | 2.8543 mL | 7.1357 mL | |
| 30 mM | 0.2379 mL | 1.1893 mL | 2.3786 mL | 5.9464 mL | |
| 40 mM | 0.1784 mL | 0.8920 mL | 1.7839 mL | 4.4598 mL | |
| 50 mM | 0.1427 mL | 0.7136 mL | 1.4271 mL | 3.5679 mL | |
| 60 mM | 0.1189 mL | 0.5946 mL | 1.1893 mL | 2.9732 mL | |
| 80 mM | 0.0892 mL | 0.4460 mL | 0.8920 mL | 2.2299 mL | |
| 100 mM | 0.0714 mL | 0.3568 mL | 0.7136 mL | 1.7839 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Imidazole-5-propionic acid Related Classifications
HY-W045271 Related Classifications
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