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  4. Imidazole-5-propionic acid

Imidazole-5-propionic acid  (Synonyms: Imidazolepropionic acid)

Cat. No.: HY-W045271 Purity: 99.99%
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Imidazole-5-propionic acid (Imidazolepropionic acid) is a urinary metabolite of L-histidine (HY-N0832). Imidazole-5-propionic acid can be used in the research of intestinal diseases and cardiovascular diseases.

For research use only. We do not sell to patients.

CAS No. : 1074-59-5

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Imidazole-5-propionic acid:

Imidazole-5-propionic acid Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Imidazole-5-propionic acid

Cell Proliferation/Viability Assay
Cell Imaging/Staining
Cell Migration/Invasion Assay
In Vivo Efficacy Study
Histological Imaging/Staining

    Imidazole-5-propionic acid purchased from MedChemExpress. Usage Cited in: Mol Med. 2025 Jan 16;31(1):14.  [Abstract]

    Imidazole-5-propionic acid (IMP) (2-12 mM; 24-48 h) significantly decreased the viability of PC3 and DU145 cells in a dose-dependent manner.

    Imidazole-5-propionic acid purchased from MedChemExpress. Usage Cited in: Mol Med. 2025 Jan 16;31(1):14.  [Abstract]

    Imidazole-5-propionic acid (IMP) (5-10 mM) significantly reduced the number of EdU-stained cells in the PC3 and DU145 cell lines.

    Imidazole-5-propionic acid purchased from MedChemExpress. Usage Cited in: Mol Med. 2025 Jan 16;31(1):14.  [Abstract]

    Imidazole-5-propionic acid (IMP) (1-10 mM) reduced the migratory ability of PC3 and DU145 cells.

    Imidazole-5-propionic acid purchased from MedChemExpress. Usage Cited in: Mol Med. 2025 Jan 16;31(1):14.  [Abstract]

    Imidazole-5-propionic acid (IMP) (40 mg/mL; i.p.; twice a day) significantly reduced tumor volume and weight in subcutaneous xenograft mice.

    Imidazole-5-propionic acid purchased from MedChemExpress. Usage Cited in: Mol Med. 2025 Jan 16;31(1):14.  [Abstract]

    Imidazole-5-propionic acid (IMP) (40 mg/mL; i.p.; twice a day) preserved tumor tissue structure, reduced Ki-67 expression, and increased PDZK1 expression in the tumor tissue of subcutaneous xenograft mice.

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    Human Endogenous Metabolite Microbial Metabolite

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    Description

    Imidazole-5-propionic acid (Imidazolepropionic acid) is a urinary metabolite of L-histidine (HY-N0832). Imidazole-5-propionic acid can be used in the research of intestinal diseases and cardiovascular diseases[1][2][3].

    IC50 & Target[1]

    Human Endogenous Metabolite

     

    In Vitro

    Imidazole-5-propionic acid can be used in research on intestinal diseases[2].
    Imidazole-5-propionic acid has emerged as a significant mediator linking gut microbiota dysbiosis to atherosclerosis and cardiovascular disease, or coronary artery disease (CAD)[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Imidazole-5-propionic acid Related Antibodies
    Molecular Weight

    140.14

    Formula

    C6H8N2O2
    CAS No.
    Appearance

    Solid

    Color

    Off-white to light yellow

    SMILES

    C(CC(=O)O)C1=CN=CN1
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    H2O : 100 mg/mL (713.57 mM; Need ultrasonic)

    DMSO : < 1 mg/mL (insoluble or slightly soluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 7.1357 mL 35.6786 mL 71.3572 mL
    5 mM 1.4271 mL 7.1357 mL 14.2714 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.99%

    SDS (393 KB)

    COA (246 KB) HNMR (118 KB) RP-HPLC (256 KB) MS (300 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 7.1357 mL 35.6786 mL 71.3572 mL 178.3930 mL
    5 mM 1.4271 mL 7.1357 mL 14.2714 mL 35.6786 mL
    10 mM 0.7136 mL 3.5679 mL 7.1357 mL 17.8393 mL
    15 mM 0.4757 mL 2.3786 mL 4.7571 mL 11.8929 mL
    20 mM 0.3568 mL 1.7839 mL 3.5679 mL 8.9197 mL
    25 mM 0.2854 mL 1.4271 mL 2.8543 mL 7.1357 mL
    30 mM 0.2379 mL 1.1893 mL 2.3786 mL 5.9464 mL
    40 mM 0.1784 mL 0.8920 mL 1.7839 mL 4.4598 mL
    50 mM 0.1427 mL 0.7136 mL 1.4271 mL 3.5679 mL
    60 mM 0.1189 mL 0.5946 mL 1.1893 mL 2.9732 mL
    80 mM 0.0892 mL 0.4460 mL 0.8920 mL 2.2299 mL
    100 mM 0.0714 mL 0.3568 mL 0.7136 mL 1.7839 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Imidazole-5-propionic acid Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Imidazole-5-propionic acid1074-59-5Imidazolepropionic acidEndogenous MetaboliteAmino Acid Derivativeshistidine metaboliteInhibitorinhibitorinhibit

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