56-65-5
56-65-5
Chemical Structure
ATP
Synonym(s): Adenosine 5'-triphosphate
- CAS No.: 56-65-5
- Formula:C10H16N5O13P3
- Molecular Weight:507.18
IUPAC Name: ((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate
InChIKey: ZKHQWZAMYRWXGA-KQYNXXCUSA-N
SMILES: O=P(O)(O)OP(OP(OC[C@H]1O[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@H](O)[C@@H]1O)(O)=O)(O)=O
Biological Activity: ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation. ATP can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP has anti-bacterial infection effects and can protect mice against bacterial infection in mice[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ATP | 99.88% | ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation. ATP can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP has anti-bacterial infection effects and can protect mice against bacterial infection in mice. | ||||||||||||||||||||
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ATP (Standard) | 95.70% | ATP (Standard) is the analytical standard of ATP. This product is intended for research and analytical applications. ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation.
In Vitro: ATP (5 mM; 1 hour) co-treatment with LPS (1 μg/mL) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs. ATP (2 mM; 0.5-24 hours) induces secretion of IL-1β, KC and MIP-2 from BMDMs in a caspase-1 activation-dependent manner. ATP promotes neutrophil chemotaxis in vitro. In Vivo: ATP (50 mg/kg; i.p.) protects mice against bacterial infection in vivo. ATP induces the secretion of IL-1β, KC and MIP-2 and neutrophils recruitment in vivo. |
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Adenosine 5'-triphosphate-13C10,15N5 ammonium solution (100mM) | 98.13% | Adenosine 5'-triphosphate-13C10,15N5 (ammonium) is the 13C and 15N labeled Adenosine 5'-triphosphate ammonium. | ||||||||||||||||||||
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ATP-13C2 dilithium | 96.0% | ATP-13C2 (Adenosine 5'-triphosphate-13C2) dilithium is 13C-labeled ATP (HY-B2176). ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation. | ||||||||||||||||||||
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ATP-13C10,15N5,d14 (dilithium) | ATP-13C10,15N5,d14 (Adenosine 5'-triphosphate-13C10,15N5,d14) dilithium is the 13C-, 15N- and deuterium labeled ATP dilithium. ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation. ATP can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP has anti-bacterial infection effects and can protect mice against bacterial infection in mice. | |||||||||||||||||||||
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ATP-13C10 dilithium | 99.94% | ATP-13C10 (Adenosine 5'-triphosphate-13C10) dilithium is 13C-labeled ATP (HY-B2176). ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation. | ||||||||||||||||||||
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ATP-d14 dilithium | 99.30% | ATP-d14 (Adenosine 5'-triphosphate-d14) dilithium is deuterium labeled ATP (HY-B2176). ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation. | ||||||||||||||||||||
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Adenosine 5'-triphosphate-13C10,15N5 dilithium | 99.82% | Adenosine 5'-triphosphate-13C10,15N5 dilithium is 13C and 15N labeled dilithium salt form of Adenosine 5'-triphosphate (HY-B2176). Adenosine 5'-triphosphate is a central component of energy storage and metabolism in vivo. Adenosine 5'-triphosphate provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. Adenosine 5'-triphosphate is an important endogenous signaling molecule in immunity and inflammation. | ||||||||||||||||||||
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Adenosine 5'-triphosphate(ATP)-d4 ammonium solution (100mM) | 97.25% | Adenosine 5'-triphosphate(ATP)-d4 (ammonium salt) is the deuterium labeled Adenosine 5'-triphosphate(ATP) ammonium salt. | ||||||||||||||||||||
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ATP-15N5,d14 dilithium | 98% | ATP-15N5,d14 (Adenosine 5'-triphosphate-15N5,d14) dilithium is deuterium and 15N labeled ATP (HY-B2176). ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation. | ||||||||||||||||||||
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ATP-15N5 dilithium | 99.99% | ATP-15N5 (Adenosine 5'-triphosphate-15N5) dilithium is 15N labeled ATP (HY-B2176). ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation. | ||||||||||||||||||||
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References
- [1]. Swennen EL, et al. Immunoregulatory effects of adenosine 5'-triphosphate on cytokine release from stimulated whole blood. Eur J Immunol. 2005 Mar;35(3):852-8. [Content Brief]
- [2]. M J L Bours, et al. Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther. 2006 Nov;112(2):358-404. [Content Brief]
- [3]. Shuo Xu, et al. Doxycycline inhibits NAcht Leucine-rich repeat Protein 3 inflammasome activation and interleukin-1β production induced by Porphyromonas gingivalis-lipopolysaccharide and adenosine triphosphate in human gingival fibroblasts. Arch Oral Biol. 2019 Nov;107:104514. [Content Brief]
- [4]. Yang Xiang, et al. Adenosine-5'-Triphosphate (ATP) Protects Mice against Bacterial Infection by Activation of the NLRP3 Inflammasome. PLoS One. 2013; 8(5): e63759. [Content Brief]
Keywords
- ATP
- ATP (Standard)
- Adenosine 5'-triphosphate-13C10,15N5 ammonium solution (100mM)
- ATP-13C2 dilithium
- ATP-13C10,15N5,d14 (dilithium)
- ATP-13C10 dilithium
- ATP-d14 dilithium
- Adenosine 5'-triphosphate-13C10,15N5 dilithium
- Adenosine 5'-triphosphate(ATP)-d4 ammonium solution (100mM)
- ATP-15N5,d14 dilithium
- ATP-15N5 dilithium
