ATP magnesium
Based on 144 publication(s) in Google Scholar
ATP (Adenosine 5'-triphosphate) magnesium is a central component of energy storage and metabolism in vivo. ATP magnesium provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP magnesium is an important endogenous signaling molecule in immunity and inflammation.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 1476-84-2
- Formula: C10H16MgN5O13P3
- Molecular Weight:531.49
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications Citing Use of MedChemExpress (MCE) ATP magnesium
More- Signal Transduct Target Ther. 2026 Mar 12;11(1):90. [Abstract]
- Cell. 2025 Dec 11;188(25):7194-7205.e10. [Abstract]
- Cell. 2025 Jul 24;188(15):4025-4042.e20. [Abstract]
- Cell. 2025 Jul 10;188(14):3744-3756.e16. [Abstract]
- Nat Biomed Eng. 2026 Jan 7.
- Immunity. 2025 Sep 9;58(9):2320-2335.e9. [Abstract]
- Immunity. 2024 Mar 12;57(3):495-512.e11. [Abstract]
- Cell Res. 2025 Feb;35(2):97-116. [Abstract]
- Mol Cell. 2026 Jan 8;86(1):150-165.e9. [Abstract]
- Cancer Res. 2025 Jul 25. [Abstract]
- Mol Cell. 2023 Jun 15;83(12):2137-2147.e4. [Abstract]
- Mol Cell. 2022 Jun 2;82(11):2032-2049.e7. [Abstract]
- ACS Nano. 2023 Dec 12;17(23):23872-23888. [Abstract]
- Cell Death Differ. 2025 Nov 10. [Abstract]
- Cell Death Differ. 2022 Feb;29(2):439-450. [Abstract]
- Acta Pharm Sin B. 2026 Mar 10.
- Autophagy. 2025 Aug 16. [Abstract]
- Autophagy. 2025 Mar 28. [Abstract]
- Adv Sci (Weinh). 2025 Nov 11:e08957. [Abstract]
- Adv Sci (Weinh). 2025 Sep 26:e08991. [Abstract]
- Adv Sci (Weinh). 2025 Jun 10:e01532. [Abstract]
- J Adv Res. 2026 Mar 12:S2090-1232(26)00239-0. [Abstract]
- Protein Cell. 2022 Apr;13(4):281-301. [Abstract]
- Carbohydr Polym. 2020 Jun 1;237:116163. [Abstract]
- J Hazard Mater. 2025 Dec 2:501:140687. [Abstract]
- Biosens Bioelectron. 2021 Apr 15;178:113025. [Abstract]
- Mater Today Bio. 2025 May 10:32:101838. [Abstract]
- Mater Today Bio. 2025 Feb 1:31:101539. [Abstract]
- Cancer Lett. 2024 Jul 29:217145. [Abstract]
- Burns Trauma. 2026 Jan 6.
- Cell Death Dis. 2022 Oct 8;13(10):860. [Abstract]
- Cell Death Dis. 2021 Dec 14;12(12):1159. [Abstract]
- Cell Death Dis. 2020 Feb 18;11(2):132. [Abstract]
- Crit Care. 2021 Oct 12;25(1):356. [Abstract]
- ACS Sens. 2026 Mar 27;11(3):1891-1907. [Abstract]
- Proc Natl Acad Sci U S A. 2025 Feb 25;122(8):e2424906122. [Abstract]
- Cell Commun Signal. 2025 Jul 8;23(1):327. [Abstract]
- Int J Biol Macromol. 2026 May:361:151905. [Abstract]
- Int J Biol Macromol. 2025 Dec 30;339(Pt 2):149976. [Abstract]
- Int J Biol Macromol. 2024 Apr 27;268(Pt 2):131779. [Abstract]
- Acta Pharmacol Sin. 2025 Jul 17. [Abstract]
- Acta Pharmacol Sin. 2025 Apr 7. [Abstract]
- Acta Pharmacol Sin. 2022 Aug;43(8):2016-2025. [Abstract]
- Phytomedicine. 2026 Jan 16:153:157839. [Abstract]
- Phytomedicine. 2025 Dec:149:157563. [Abstract]
- EMBO J. 2025 Aug 18. [Abstract]
- Phytomedicine. 2025 Jul:142:156698. [Abstract]
- Phytomedicine. 2024 Jan:123:155193. [Abstract]
- Phytomedicine.2023 Sep:118:154971. [Abstract]
- Free Radic Biol Med. 2025 Dec 22:245:98-114. [Abstract]
- J Orthop Translat. 2026 Jan 6.
- Br J Pharmacol. 2025 May 13. [Abstract]
- Biomed Pharmacother. 2025 Nov 12:193:118748. [Abstract]
- Biomed Pharmacother. 2025 Jun 17:189:118275. [Abstract]
- J Transl Med. 2024 Sep 27;22(1):871. [Abstract]
- Biomed Pharmacother. 2024 Jun 21:177:117006. [Abstract]
- Biomed Pharmacother. 2024 Jun 24:177:116952. [Abstract]
- Biomed Pharmacother. 2024 Jul 15:177:117111. [Abstract]
- Stem Cell Res Ther. 2025 May 1;16(1):222. [Abstract]
- Cell Rep. 2025 Nov 25;44(12):116620. [Abstract]
- Cell Rep. 2025 Jan 10;44(1):115203. [Abstract]
- Cell Rep. 2024 Jun 27;43(7):114402. [Abstract]
- Cell Rep. 2021 Aug 10;36(6):109516. [Abstract]
- J Med Chem. 2026 Apr 9;69(7):7663-7676. [Abstract]
- Anal Chem. 2025 May 13;97(18):9827-9835. [Abstract]
- Antioxidants (Basel). 2023 Jun 19;12(6):1304. [Abstract]
- Antioxidants (Basel). 2022 Nov 23;11(12):2315. [Abstract]
- Mol Med. 2025 Jun 16;31(1):240. [Abstract]
- J Agric Food Chem. 2024 Sep 25;72(38):20959-20973. [Abstract]
- Cancer Cell Int. 2023 May 9;23(1):87. [Abstract]
- Anal Chim Acta. 2021 Dec 15:1188:339180. [Abstract]
- Eur J Med Chem. 2026 May 5:309:118765. [Abstract]
- Transl Res. 2023 May:255:1-13. [Abstract]
- Biochem Pharmacol. 2026 Feb:244:117614. [Abstract]
- Biochem Pharmacol. 2025 Feb 12:234:116801. [Abstract]
- Biochem Pharmacol. 2024 Jun 19:116377. [Abstract]
- Cell Prolif. 2023 Sep;56(9):e13442. [Abstract]
- Am J Chin Med. 2025;53(2):501-522. [Abstract]
- J Ethnopharmacol. 2026 May 10:362:121370. [Abstract]
- J Ethnopharmacol. 2026 Mar 25:359:121046. [Abstract]
- J Ethnopharmacol. 2025 Jul 30;353(Pt A):120346. [Abstract]
- Food Funct. 2025 Jun 16;16(12):4731-4753. [Abstract]
- J Ethnopharmacol. 2024 Jun 28:328:118057. [Abstract]
- J Ethnopharmacol. 2024 Feb 10:320:117388. [Abstract]
- Life Sci. 2021 Apr 15:271:119192. [Abstract]
- Inflammation. 2025 Dec 20;49(1):11. [Abstract]
- Respir Res. 2024 Jul 30;25(1):291. [Abstract]
- Nutrients. 2021 Dec 14;13(12):4462. [Abstract]
- Int J Mol Sci. 2024 Sep 26;25(19):10366. [Abstract]
- Eur J Pharmacol. 2026 Mar 28:1019:178738. [Abstract]
- Int Immunopharmacol. 2025 Oct 22:167:115697. [Abstract]
- Int Immunopharmacol. 2025 Sep 5:165:115437. [Abstract]
- Int Immunopharmacol. 2025 Jan 18:148:114057. [Abstract]
- Int Immunopharmacol. 2024 Nov 2;143(Pt 3):113527. [Abstract]
- Eur J Pharmacol. 2023 May 15:947:175681. [Abstract]
- Int Immunopharmacol. 2023 Mar:116:109747. [Abstract]
- Eur J Pharmacol. 2022 Feb 5:916:174729. [Abstract]
- Immunotargets Ther. 2024 Dec 14:13:775-788. [Abstract]
- Structure. 2025 May 1;33(5):903-915.e5. [Abstract]
- Appl Microbiol Biotechnol. 2024 Jan 25;108(1):173. [Abstract]
- FEBS J. 2026 Mar 10. [Abstract]
- Exp Neurol. 2026 Feb:396:115537. [Abstract]
- J Cell Mol Med. 2025 Jan;29(2):e70338. [Abstract]
- Biochim Biophys Acta Mol Basis Dis. 2024 Jan;1870(1):166895. [Abstract]
- J Inflamm Res. 2025 Jul 19:18:9587-9608. [Abstract]
- Neurochem Int. 2025 Jul:187:105992. [Abstract]
- Neuromolecular Med. 2023 Jun;25(2):230-241. [Abstract]
- Aging (Albany NY). 2021 Sep 28;13(18):22588-22610. [Abstract]
- Aging (Albany NY). 2021 Mar 10;13(6):8588-8598. [Abstract]
- J Virol. 2023 Mar 30;97(3):e0000323. [Abstract]
- Biochim Biophys Acta Mol Cell Res. 2024 Mar 22;1871(4):119712. [Abstract]
- Biochim Biophys Acta Mol Cell Res. 2024 Jan;1871(1):119595. [Abstract]
- Heliyon. 2024 Sep 19;10(19):e38050. [Abstract]
- Reprod Biomed Online. 2024 Oct;49(4):104319. [Abstract]
- Front Neurosci. 2022 Jun 7;16:901688. [Abstract]
- J Dent Sci. 2025 Jul;20(3):1422-1435. [Abstract]
- Clin Oral Investig. 2023 Jun;27(6):2875-2885. [Abstract]
- Mol Immunol. 2024 May:169:86-98. [Abstract]
- Biochemistry. 2023 Dec 5;62(23):3396-3410. [Abstract]
- Bioorg Med Chem. 2021 Jan 1;29:115899. [Abstract]
- Oral Dis. 2021 Jul;27(5):1148-1160. [Abstract]
- Mol Biol Rep. 2026 Jan 3;53(1):250. [Abstract]
- Int J Biochem Cell Biol. 2026 Jan:190:106880. [Abstract]
- Vet Microbiol. 2025 Aug:307:110628. [Abstract]
- Placenta. 2025 May 22:167:204-215. [Abstract]
- Vet Sci. 2024 Dec 12;11(12):643. [Abstract]
- Biochem Biophys Res Commun. 2024 May 14:708:149814. [Abstract]
- Hypertens Pregnancy. 2026 Dec 31;45(1):2609374. [Abstract]
- Brain Mechanisms. 2025 Nov 21.
- Arch Oral Biol. 2019 Nov:107:104514. [Abstract]
- Cardiovasc Pathol. 2025 Jul 4:79:107750. [Abstract]
- Cytotechnology. 2025 Apr;77(2):66. [Abstract]
- Int J Dev Neurosci. 2023 Feb;83(1):53-66. [Abstract]
- bioRxiv. 2026 Jan 13.
- SSRN. 2024 Nov 19.
- Res Sq. 2024 Sep 22.
- Research Square Preprint. 2024 Apr 9.
- bioRxiv. 2024 Apr 21.
- Research Square Preprint. 2023 Sep 8.
- SSRN. 2023 May 12.
- SSRN. 6 Dec 2022.
- Research Square Preprint. 2022 May.
- Research Square Preprint. 2022 Feb.
- Research Square Preprint. 2021 Jul.
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WB
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WB
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Cell Proliferation/Viability Assay
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WB
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RT-PCR
All Endogenous Metabolite Isoforms
More
Biological Activity
ATP (5 mM; 1 hour) co-treatment with LPS (1 μg/mL) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs[3].
ATP (2 mM; 0.5-24 hours) induces secretion of IL-1β, KC and MIP-2 from BMDMs in a caspase-1 activation-dependent manner[4].
ATP promotes neutrophil chemotaxis in vitro[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1476-84-2
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Appearance Solid
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Molecular Weight 531.49
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Formula C10H16MgN5O13P3
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Color White to off-white
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SMILES
O=P(O)(O)OP(OP(OC[C@H]1O[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@H](O)[C@@H]1O)(O)=O)(O)=O.[Mg]
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Synonyms
Adenosine 5'-triphosphate magnesium
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (144)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Cyclic guanosine monophosphate-protein kinase G signaling attenuates aortic valve calcification through ULK1-mediated autophagy. [Abstract]2026 Mar 12;11(1):90. PMID: 41820291 -
Cell
Structural basis for the concurrence of template recycling and RNA capping in SARS-CoV-2. [Abstract]2025 Dec 11;188(25):7194-7205.e10. PMID: 41130208 -
Cell
Proximity between LAG-3 and the T cell receptor guides suppression of T cell activation and autoimmunity. [Abstract]2025 Jul 24;188(15):4025-4042.e20. PMID: 40592325 -
Cell
Cyclic-dinucleotide-induced filamentous assembly of phospholipases governs broad CBASS immunity. [Abstract]2025 Jul 10;188(14):3744-3756.e16. PMID: 40345202 -
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Immunity
Spatiotemporal dynamics of CXCL10 encode contextual immune information revealed by the genetically encoded fluorescent sensor. [Abstract]2025 Sep 9;58(9):2320-2335.e9. PMID: 40818452 -
Immunity
Disruption of the Na+/K+-ATPase-purinergic P2X7 receptor complex in microglia promotes stress-induced anxiety. [Abstract]2024 Mar 12;57(3):495-512.e11. PMID: 38395698
ATP magnesium purchased from MedChemExpress. Usage Cited in: Immunity. 2024 Mar 12;57(3):495-512.e11. [Abstract]
Representative western blots and analyses of the following proteins in BV2 cells treated with vehicle (Con), LPS (200 ng/ml, 3 h), LPS + ATP (3 mM, 30 min), or LPS + ATP-siNKAα1.
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Cell Res
Nonenzymatic lysine D-lactylation induced by glyoxalase II substrate SLG dampens inflammatory immune responses. [Abstract]2025 Feb;35(2):97-116. PMID: 39757301 -
Mol Cell
Mitochondrial glutamine import sustains electron transport chain integrity independently of glutaminolysis in cancer. [Abstract]2026 Jan 8;86(1):150-165.e9. PMID: 41435838 -
Cancer Res
Mitochondrial Calcium Uniporter Links Acetyl-CoA Metabolism and H3K27 Acetylation to Maintain Glioblastoma Stem Cells. [Abstract]2025 Jul 25. PMID: 40712058 -
Mol Cell
2023 Jun 15;83(12):2137-2147.e4. PMID: 37244256 -
Mol Cell
Cytoplasmic PARP1 links the genome instability to the inhibition of antiviral immunity through PARylating cGAS. [Abstract]2022 Jun 2;82(11):2032-2049.e7. PMID: 35460603 -
ACS Nano
2023 Dec 12;17(23):23872-23888. PMID: 38084420 -
Cell Death Differ
OR2T6 modulates autophagy through the PPP3CA-mediated pathways to suppress gastric cancer. [Abstract]2025 Nov 10. PMID: 41214150 -
Cell Death Differ
2022 Feb;29(2):439-450. PMID: 34511601
ATP magnesium purchased from MedChemExpress. Usage Cited in: Cell Death Differ. 2022 Feb;29(2):439-450. [Abstract]
Primary BMDM cells were isolated from WT and Trim21-/- C57BL/6 mice. Cells were primed with 1 μg/mL LPS for 2 h followed by 5 mM ATP or 20 μM Nig or 30 μM flagellin for 30 min. Cell viability are determined by the Cell Counting Kit-8.
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Autophagy
Inhibition of UBE2N promotes the clearance of mutant HTT (huntingtin) in HD knock-in mice. [Abstract]2025 Aug 16. PMID: 40818063 -
Autophagy
ESCRT III-mediated lysosomal repair improve renal tubular cell injury in cisplatin-induced AKI. [Abstract]2025 Mar 28. PMID: 40152606 -
Adv Sci (Weinh)
Mitochondrial CISD1 Modulates Microglial Metabolic Reprogramming to Drive Stress Susceptibility in Mice. [Abstract]2025 Nov 11:e08957. PMID: 41215712 -
Adv Sci (Weinh)
Acetylation of the Mitochondrial Chaperone GRP75 Governs ER-Mitochondrial Calcium Homeostasis and Hepatocyte Insulin Resistance. [Abstract]2025 Sep 26:e08991. PMID: 41001747 -
Adv Sci (Weinh)
2025 Jun 10:e01532. PMID: 40492417 -
J Adv Res
Conjugated bile acids facilitate cholangiocyte senescence to promote cholestatic liver diseases via STING signaling. [Abstract]2026 Mar 12:S2090-1232(26)00239-0. PMID: 41831676 -
Protein Cell
Drug target inference by mining transcriptional data using a novel graph convolutional network framework. [Abstract]2022 Apr;13(4):281-301. PMID: 34677780 -
Carbohydr Polym
The effect of doxycycline-containing chitosan/carboxymethyl chitosan nanoparticles on NLRP3 inflammasome in periodontal disease. [Abstract]2020 Jun 1;237:116163. PMID: 32241426 -
J Hazard Mater
Protection against deoxynivalenol (DON)-induced intestinal injury by sulforaphane via modulation of lysosomal function. [Abstract]2025 Dec 2:501:140687. PMID: 41352012 -
Biosens Bioelectron
2021 Apr 15;178:113025. PMID: 33529860 -
Mater Today Bio
Nanotube topography inhibits NLRP3 inflammasome activation by reducing microtubule glutamylation. [Abstract]2025 May 10:32:101838. PMID: 40487178 -
Mater Today Bio
Nature-derived microneedles with metal-polyphenolic networks encapsulation for chronic soft tissue defects repair: Responding and remodeling the regenerative microenvironment. [Abstract]2025 Feb 1:31:101539. PMID: 40026624 -
Cancer Lett
Sulforaphane suppresses bladder cancer metastasis via blocking actin nucleation-mediated pseudopodia formation. [Abstract]2024 Jul 29:217145. PMID: 39084455 -
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Cell Death Dis
Inhibition of p38 MAPK or immunoproteasome overcomes resistance of chronic lymphocytic leukemia cells to Bcl-2 antagonist venetoclax. [Abstract]2022 Oct 8;13(10):860. PMID: 36209148 -
Cell Death Dis
2021 Dec 14;12(12):1159. PMID: 34907173 -
Cell Death Dis
Silencing lncRNA Lfar1 alleviates the classical activation and pyoptosis of macrophage in hepatic fibrosis. [Abstract]2020 Feb 18;11(2):132. PMID: 32071306
ATP magnesium purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2020 Feb 18;11(2):132. [Abstract]
KCs were stimulated with 100 ng/mL LPS for 4 hours and subsequently treated them with 5 mM ATP for 2 hours to induce pyroptosis. The RNA level of lnc-Lfar1 was determined by qRT-PCR.
ATP magnesium purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2020 Feb 18;11(2):132. [Abstract]
KCs were transfected with lnc-Lfar1 siRNA for 24 h, followed by stimulation with 100 ng/ml LPS for 4 h and subsequently treated with 5 mM ATP or 100 ng/ml for 2 h to induce pyroptosis. a, b The protein level of NLRP3, Caspase1 and GSDMD was determined by western blot. GAPDH was used as an internal control.
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Crit Care
Exosomal miR-30d-5p of neutrophils induces M1 macrophage polarization and primes macrophage pyroptosis in sepsis-related acute lung injury. [Abstract]2021 Oct 12;25(1):356. PMID: 34641966
ATP magnesium purchased from MedChemExpress. Usage Cited in: Crit Care. 2021 Oct 12;25(1):356. [Abstract]
Stimulation of Raw264.7 macrophages with PBS/PBS-Exo/TNF-Exo for 24 h and treatment with PBS, 5 mM ATP or 20 mM nigericin for 2 h. Cleavage of GSDMD by western blot. GSDMD-FL: full-length GSDMD, GSDMD-N: N-terminal cleavage products of GSDMD.
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ACS Sens
A Sensitive Green-Red FRET Sensor for Calpain-1 Utilizing Heterodimeric Fluorescent Proteins from Distinct Evolutionary Origins. [Abstract]2026 Mar 27;11(3):1891-1907. PMID: 41837894 -
Proc Natl Acad Sci U S A
Stepwise activation of SARM1 for cell death and axon degeneration revealed by a biosynthetic NMN mimic. [Abstract]2025 Feb 25;122(8):e2424906122. PMID: 39964720 -
Cell Commun Signal
JC124 confers multimodal neuroprotection in epilepsy by suppressing NLRP3 inflammasome activation: evidence from animal and human neuronal models. [Abstract]2025 Jul 8;23(1):327. PMID: 40629339 -
Int J Biol Macromol
NIM5 series brain-penetrant NLRP3 inflammasome inhibitors suppress neuroinflammation in EAE and Alzheimer's models. [Abstract]2026 May:361:151905. PMID: 41962712 -
Int J Biol Macromol
2025 Dec 30;339(Pt 2):149976. PMID: 41478474 -
Int J Biol Macromol
2024 Apr 27;268(Pt 2):131779. PMID: 38679250 -
Acta Pharmacol Sin
Identification of AKOS, a Chikungunya virus inhibitor, as a USP14 inhibitor for colorectal cancer treatment. [Abstract]2025 Jul 17. PMID: 40676218 -
Acta Pharmacol Sin
Direct inhibition of the TXNIP-NLRP3-GSDMD pathway reduces pyroptosis in colonocytes and alleviates ulcerative colitis in mice by the small compound PEITC. [Abstract]2025 Apr 7. PMID: 40195510 -
Acta Pharmacol Sin
Sapidolide A alleviates acetaminophen-induced acute liver injury by inhibiting NLRP3 inflammasome activation in macrophages. [Abstract]2022 Aug;43(8):2016-2025. PMID: 35022542 -
Phytomedicine
Isodeoxyelephantopin mitigates DSS-induced ulcerative colitis by suppressing IL-1β-driven inflammation via the TXNIP/NLRP3 axis. [Abstract]2026 Jan 16:153:157839. PMID: 41655542 -
Phytomedicine
Sclareol alleviates synovial inflammation in knee osteoarthritis by regulating sphingolipid metabolism along the gut-bone axis. [Abstract]2025 Dec:149:157563. PMID: 41273871 -
EMBO J
Speedy A governs non-homologous XY chromosome desynapsis as a unique prerequisite for XY loop-axis organization. [Abstract]2025 Aug 18. PMID: 40826181 -
Phytomedicine
Ophiopogonin C protects against acute lung injury by fatal sepsis through pyroptosis macrophage. [Abstract]2025 Jul:142:156698. PMID: 40397999 -
Phytomedicine
Lupeol alleviates autoimmune myocarditis by suppressing macrophage pyroptosis and polarization via PPARα/LACC1/NF-κB signaling pathway. [Abstract]2024 Jan:123:155193. PMID: 37976692 -
Phytomedicine
Geniposide alleviated bile acid-associated NLRP3 inflammasome activation by regulating SIRT1/FXR signaling in bile duct ligation-induced liver fibrosis. [Abstract]2023 Sep:118:154971. PMID: 37494875 -
Free Radic Biol Med
Paeoniflorin mitigates myocardial hypertrophy by regulating mitophagy and ferroptosis mediated by mitochondria-associated AMPK-Parkin-ACSL4 pathway. [Abstract]2025 Dec 22:245:98-114. PMID: 41443335 -
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Br J Pharmacol
Contributions of synaptic energetic dysfunction by microtubule dynamics and microtubule-based mitochondrial transport disorder to morphine tolerance. [Abstract]2025 May 13. PMID: 40361281 -
Biomed Pharmacother
Docking and database screening identify manidipine as a potential modulator of matrix metalloproteinase-7 in chronic kidney disease. [Abstract]2025 Nov 12:193:118748. PMID: 41232355 -
Biomed Pharmacother
Cilostazol attenuates vascular inflammation via the regulation of TICAM1/IRF3 signaling pathway. [Abstract]2025 Jun 17:189:118275. PMID: 40532577 -
J Transl Med
Vascular restenosis following paclitaxel-coated balloon therapy is attributable to NLRP3 activation and LIN9 upregulation. [Abstract]2024 Sep 27;22(1):871. PMID: 39334121 -
Biomed Pharmacother
Ginkgolide B effectively mitigates neuropathic pain by suppressing the activation of the NLRP3 inflammasome through the induction of mitophagy in rats. [Abstract]2024 Jun 21:177:117006. PMID: 38908197 -
Biomed Pharmacother
Gentiopicroside improves NASH and liver fibrosis by suppressing TLR4 and NLRP3 signaling pathways. [Abstract]2024 Jun 24:177:116952. PMID: 38917754 -
Biomed Pharmacother
Bongkrekic acid alleviates airway inflammation via breaking the mPTP/mtDAMPs/RAGE feedback loop in a steroid-insensitive asthma model. [Abstract]2024 Jul 15:177:117111. PMID: 39013220 -
Stem Cell Res Ther
Enhance the therapeutic efficacy of human umbilical cord-derived mesenchymal stem cells in prevention of acute graft-versus-host disease through CRISPLD2 modulation. [Abstract]2025 May 1;16(1):222. PMID: 40312744 -
Cell Rep
Glutamine synthetase modulates YAP activation by stabilizing LATS under glutamine homeostasis. [Abstract]2025 Nov 25;44(12):116620. PMID: 41296569 -
Cell Rep
Ergosterol alleviates hepatic steatosis and insulin resistance via promoting fatty acid β-oxidation by activating mitochondrial ACSL1. [Abstract]2025 Jan 10;44(1):115203. PMID: 39799570 -
Cell Rep
Translocational attenuation mediated by the PERK-SRP14 axis is a protective mechanism of unfolded protein response. [Abstract]2024 Jun 27;43(7):114402. PMID: 38943644 -
Cell Rep
NAD+ supplement potentiates tumor-killing function by rescuing defective TUB-mediated NAMPT transcription in tumor-infiltrated T cells. [Abstract]2021 Aug 10;36(6):109516. PMID: 34380043 -
J Med Chem
Platinum-Paeonol Complexes as ERK Inhibitors To Restrain Melanoma and Relieve Cancer Pain. [Abstract]2026 Apr 9;69(7):7663-7676. PMID: 41873204 -
Anal Chem
Ultrahigh Flow Regulated Discharge Coupling with Targeted Mass Spectrometry Analysis: Real Time Capturing Biomolecules in Exhaled Breath. [Abstract]2025 May 13;97(18):9827-9835. PMID: 40302637 -
Antioxidants (Basel)
2023 Jun 19;12(6):1304. PMID: 37372033 -
Antioxidants (Basel)
Blocking TRPV4 Ameliorates Osteoarthritis by Inhibiting M1 Macrophage Polarization via the ROS/NLRP3 Signaling Pathway. [Abstract]2022 Nov 23;11(12):2315. PMID: 36552524 -
Mol Med
4-Octyl itaconate alleviates endothelial cell inflammation and barrier dysfunction in LPS-induced sepsis via modulating TLR4/MAPK/NF-κB signaling : 4-Octyl itaconate alleviates endothelial dysfunction. [Abstract]2025 Jun 16;31(1):240. PMID: 40524158 -
J Agric Food Chem
Calenduloside E Ameliorates Inflammatory Responses in Adipose Tissue via Sirtuin 2-NLRP3 Inflammasome Axis. [Abstract]2024 Sep 25;72(38):20959-20973. PMID: 39282743 -
Cancer Cell Int
Gastric cancer cell-originated small extracellular vesicle induces metabolic reprogramming of BM-MSCs through ERK-PPARγ-CPT1A signaling to potentiate lymphatic metastasis. [Abstract]2023 May 9;23(1):87. PMID: 37158903 -
Anal Chim Acta
2021 Dec 15:1188:339180. PMID: 34794559 -
Eur J Med Chem
Synthesis and pharmacological evaluation of brominated derivatives of natural product celastrol for treatment of hepatic fibrosis. [Abstract]2026 May 5:309:118765. PMID: 41844113 -
Transl Res
Non-canonical NF-κB contributes to endothelial pyroptosis and atherogenesis dependent on IRF-1. [Abstract]2023 May:255:1-13. PMID: 36384204
ATP magnesium purchased from MedChemExpress. Usage Cited in: Transl Res. 2023 May:255:1-13. [Abstract]
LPS/ATP treatment significantly promotes expression of NLRP3 and production of N-GSDMD in HAEC. HAEC are pretreated with LPS (500ng/ml) for 5 h and then stimulated with ATP (5 mM) for 1 h.
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Biochem Pharmacol
Targeting the DYNLL2-PAK1 axis inhibits caspase-11-dependent pyroptosis to alleviate sepsis. [Abstract]2026 Feb:244:117614. PMID: 41360226 -
Biochem Pharmacol
Tamibarotene directly targets the NACHT domain of NLRP3 to alleviate acute myocardial infarction. [Abstract]2025 Feb 12:234:116801. PMID: 39952330 -
Biochem Pharmacol
BACH1 impairs hepatocyte regeneration after hepatectomy with repeated ischemia/reperfusion by reprogramming energy metabolism and exacerbating oxidative stress. [Abstract]2024 Jun 19:116377. PMID: 38906228 -
Cell Prolif
2023 Sep;56(9):e13442. PMID: 37086012 -
Am J Chin Med
Ophiopogonin D from Ophiopogon japonicas-induced USP25 Activity to Reduce Ferroptosis of Macrophage in Acute Lung Injury by the Inhibition of Bound Rac1 and Nox1 Complex. [Abstract]2025;53(2):501-522. PMID: 40099394 -
J Ethnopharmacol
Combining LC/IM-QTOF-MS with serum pharmacochemistry to identify active compounds and functional mechanisms of Fritillaria ussuriensis in asthma. [Abstract]2026 May 10:362:121370. PMID: 41687937 -
J Ethnopharmacol
Didymin alleviates neuropathic pain by targeting RKIP-mediated NF-κB/NLRP3 crosstalk to inhibit pyroptosis and neuroinflammation. [Abstract]2026 Mar 25:359:121046. PMID: 41453551 -
J Ethnopharmacol
Ginsenoside Rg1 improves chronic neuropathic pain by inhibiting NLRP3 inflammasome activation and cell pyroptosis in microglia. [Abstract]2025 Jul 30;353(Pt A):120346. PMID: 40750033 -
Food Funct
Ketogenic diet attenuates microglia-mediated neuroinflammation by inhibiting NLRP3 inflammasome activation via HDAC3 inhibition to activate mitophagy in experimental autoimmune encephalomyelitis. [Abstract]2025 Jun 16;16(12):4731-4753. PMID: 40421817 -
J Ethnopharmacol
Si-Wu-Tang attenuates hepatocyte PANoptosis and M1 polarization of macrophages in non-alcoholic fatty liver disease by influencing the intercellular transfer of mtDNA. [Abstract]2024 Jun 28:328:118057. PMID: 38518965 -
J Ethnopharmacol
Buyang Huanwu Decoction suppresses cardiac inflammation and fibrosis in mice after myocardial infarction through inhibition of the TLR4 signalling pathway. [Abstract]2024 Feb 10:320:117388. PMID: 37949329 -
Life Sci
GYY4137 alleviates sepsis-induced acute lung injury in mice by inhibiting the PDGFRβ/Akt/NF-κB/NLRP3 pathway. [Abstract]2021 Apr 15:271:119192. PMID: 33577850 -
Inflammation
Palmatine Attenuates Lipopolysaccharide-Induced Acute Lung Injury Via Suppression of NLRP3 Inflammasome Activation, Pyroptosis, and Metabolic Remodeling. [Abstract]2025 Dec 20;49(1):11. PMID: 41420798 -
Respir Res
Glycolytic enzyme PGK1 promotes M1 macrophage polarization and induces pyroptosis of acute lung injury via regulation of NLRP3. [Abstract]2024 Jul 30;25(1):291. PMID: 39080660 -
Nutrients
Dietary Flavone Baicalein Combinate with Genipin Attenuates Inflammation Stimulated by Lipopolysaccharide in RAW264.7 Cells or Pseudomonas aeruginosa in Mice via Regulating the Expression and Phosphorylation of AKT. [Abstract]2021 Dec 14;13(12):4462. PMID: 34960014 -
Int J Mol Sci
Betulonic Acid Inhibits Type-2 Porcine Reproductive and Respiratory Syndrome Virus Replication by Downregulating Cellular ATP Production. [Abstract]2024 Sep 26;25(19):10366. PMID: 39408695 -
Eur J Pharmacol
Blockade of KCa3.1 ameliorates rheumatoid arthritis by suppressing macrophage M1 polarization via the NLRP3 inflammasome signaling pathway. [Abstract]2026 Mar 28:1019:178738. PMID: 41794275 -
Int Immunopharmacol
Coptisine alleviates intestinal barrier dysfunction and inflammation in TNBS-induced colitis rats and LPS-stimulated human intestinal Caco-2 cells. [Abstract]2025 Oct 22:167:115697. PMID: 41130089 -
Int Immunopharmacol
Crocin facilitates peripheral nerve regeneration through modulation of the STAT3/Bcl-2/Beclin-1 signaling axis-mediated autophagic pathway. [Abstract]2025 Sep 5:165:115437. PMID: 40913861 -
Int Immunopharmacol
Urolithin A alleviates NLRP3 inflammasome activation and pyroptosis by promoting microglial mitophagy following spinal cord injury. [Abstract]2025 Jan 18:148:114057. PMID: 39827665 -
Int Immunopharmacol
CHS-Ⅳa activates the IGF1R/PI3K signal pathway with inhibited pyroptosis of endometrial stromal cells and progress of endometriosis. [Abstract]2024 Nov 2;143(Pt 3):113527. PMID: 39488924 -
Eur J Pharmacol
Bazedoxifene attenuates intestinal injury in sepsis by suppressing the NF-κB/NLRP3 signaling pathways. [Abstract]2023 May 15:947:175681. PMID: 36965746 -
Int Immunopharmacol
Calcitonin gene-related peptide ameliorates sepsis-induced intestinal injury by suppressing NLRP3 inflammasome activation. [Abstract]2023 Mar:116:109747. PMID: 36706592 -
Eur J Pharmacol
2022 Feb 5:916:174729. PMID: 34973190 -
Immunotargets Ther
NLRP3 Inflammasome Upregulates PD-L1 in Ovarian Cancer and Contributes to an Immunosuppressive Microenvironment. [Abstract]2024 Dec 14:13:775-788. PMID: 39703562 -
Structure
2025 May 1;33(5):903-915.e5. PMID: 40101709 -
Appl Microbiol Biotechnol
Preparation and characterization of monoclonal antibodies against porcine gasdermin D protein. [Abstract]2024 Jan 25;108(1):173. PMID: 38267794 -
FEBS J
2026 Mar 10. PMID: 41804674 -
Exp Neurol
Semaglutide attenuates Alzheimer's disease model progression by targeting microglial NLRP3 inflammasome-mediated neuroinflammation and ferroptosis. [Abstract]2026 Feb:396:115537. PMID: 41173224 -
J Cell Mol Med
Resveratrol Upregulates miR-124-3p Expression to Target DAPK1, Regulating the NLRP3/Caspase-1/GSDMD Pathway to Inhibit Pyroptosis and Alleviate Spinal Cord Injury. [Abstract]2025 Jan;29(2):e70338. PMID: 39833100 -
Biochim Biophys Acta Mol Basis Dis
Extracellular ATP (eATP) inhibits the progression of endometriosis and enhances the immune function of macrophages. [Abstract]2024 Jan;1870(1):166895. PMID: 37748566 -
J Inflamm Res
Cell Death-Related Genesets Activity Improved Clinical Concordance and Intrinsically Associated with Alterations in Ulcerative Colitis: Mucosal Healing at Molecular Depth. [Abstract]2025 Jul 19:18:9587-9608. PMID: 40708727 -
Neurochem Int
Proteostasis and autophagy disruption by the aging-related VGVAPG hexapeptide - preliminary insights into a potential novel elastin-induced neurodegeneration pathway in an in vitro human cellular neuron model. [Abstract]2025 Jul:187:105992. PMID: 40348194 -
Neuromolecular Med
SS-31 Improves Cognitive Function in Sepsis-Associated Encephalopathy by Inhibiting the Drp1-NLRP3 Inflammasome Activation. [Abstract]2023 Jun;25(2):230-241. PMID: 36333543 -
Aging (Albany NY)
2021 Sep 28;13(18):22588-22610. PMID: 34584017 -
Aging (Albany NY)
Inhibition of complement C5a receptor protects lung cells and tissues against lipopolysaccharide-induced injury via blocking pyroptosis. [Abstract]2021 Mar 10;13(6):8588-8598. PMID: 33714207 -
J Virol
Pseudorabies Virus Infection Activates the TLR-NF-κB Axis and AIM2 Inflammasome To Enhance Inflammatory Responses in Mice. [Abstract]2023 Mar 30;97(3):e0000323. PMID: 36877049 -
Biochim Biophys Acta Mol Cell Res
2024 Mar 22;1871(4):119712. PMID: 38521466 -
Biochim Biophys Acta Mol Cell Res
Interplay between SUMO1-related SUMOylation and phosphorylation of p65 promotes hepatocellular carcinoma progression. [Abstract]2024 Jan;1871(1):119595. PMID: 37730133 -
Heliyon
Ulinastatin modulates NLRP3 inflammasome pathway in PTZ-induced epileptic mice: A potential mechanistic insight. [Abstract]2024 Sep 19;10(19):e38050. PMID: 39386862 -
Reprod Biomed Online
Blockage of the NLRP3 inflammasome by MCC950 inhibits migration and invasion in adenomyosis. [Abstract]2024 Oct;49(4):104319. PMID: 39121559 -
Front Neurosci
Extracellular Adenosine Triphosphate Binding to P2Y1 Receptors Prevents Glutamate-Induced Excitotoxicity: Involvement of Erk1/2 Signaling Pathway to Suppress Autophagy. [Abstract]2022 Jun 7;16:901688. PMID: 35747207 -
J Dent Sci
Micro-/nano-structured zirconia surface promotes osteogenic differentiation of human bone marrow mesenchymal stem cells by reducing pyroptosis under inflammatory conditions. [Abstract]2025 Jul;20(3):1422-1435. PMID: 40654428 -
Clin Oral Investig
The protective role of curcumin in human dental pulp stem cells stimulated by lipopolysaccharide via inhibiting NF-κB p65 phosphorylation to suppress NLRP3 inflammasome activation. [Abstract]2023 Jun;27(6):2875-2885. PMID: 36735089 -
Mol Immunol
Hyperactivation of succinate dehydrogenase promotes pyroptosis of macrophage via ROS-induced GSDMD oligomerization in acute liver failure. [Abstract]2024 May:169:86-98. PMID: 38552285 -
Biochemistry
Full-Length NAD+-I Riboswitches Bind a Single Cofactor but Cannot Discriminate against Adenosine Triphosphate. [Abstract]2023 Dec 5;62(23):3396-3410. PMID: 37947391 -
Bioorg Med Chem
Synthesis and biological evaluation of all possible inosine-mixed cyclic dinucleotides that activate different hSTING variants. [Abstract]2021 Jan 1;29:115899. PMID: 33285409 -
Oral Dis
Repurposing disulfiram to induce OSCC cell death by cristae dysfunction promoted autophagy. [Abstract]2021 Jul;27(5):1148-1160. PMID: 32989819 -
Mol Biol Rep
Fucoxanthin regulates macrophage pyroptosis through the PI3K/AKT/mTOR signalling pathway. [Abstract]2026 Jan 3;53(1):250. PMID: 41483374 -
Int J Biochem Cell Biol
Paxillin mediates lung epithelial injury by activating NLRP3 inflammasomes in an acute respiratory distress syndrome mouse model. [Abstract]2026 Jan:190:106880. PMID: 41265698 -
Vet Microbiol
FCV activates NLRP3 inflammasome through ion-dependent pathway to promote IL-1β secretion. [Abstract]2025 Aug:307:110628. PMID: 40602240 -
Placenta
Endoplasmic reticulum stress induces trophoblast pyroptosis via regulating CYLD during labor initiation. [Abstract]2025 May 22:167:204-215. PMID: 40418867 -
Vet Sci
Porcine Epidemic Diarrhea Virus Infection of Porcine Intestinal Epithelial Cells Causes Mitochondrial DNA Release and the Activation of the NLRP3 Inflammasome to Mediate Interleukin-1β Secretion. [Abstract]2024 Dec 12;11(12):643. PMID: 39728983 -
Biochem Biophys Res Commun
Feedback activation of CD73-Adenosine axis attenuates the antitumor immunity of STING pathway. [Abstract]2024 May 14:708:149814. PMID: 38531218 -
Hypertens Pregnancy
KAT2A promotes NLRP3-mediated trophoblast pyroptosis in preeclampsia by the succinylation. [Abstract]2026 Dec 31;45(1):2609374. PMID: 41473982 -
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Arch Oral Biol
Doxycycline inhibits NAcht Leucine-rich repeat Protein 3 inflammasome activation and interleukin-1β production induced by Porphyromonas gingivalis-lipopolysaccharide and adenosine triphosphate in human gingival fibroblasts. [Abstract]2019 Nov:107:104514. PMID: 31394382 -
Cardiovasc Pathol
Trimethylamine N-oxide drives bioprosthetic heart valve calcification via macrophage pyroptosis in juvenile rats. [Abstract]2025 Jul 4:79:107750. PMID: 40619044 -
Cytotechnology
E2F2 induces microglial activation and augments depressive-like behavior in mice by repressing PTPN6 transcription. [Abstract]2025 Apr;77(2):66. PMID: 39991704 -
Int J Dev Neurosci
Gentiopicroside alleviated epileptogenesis in immature rats through inactivation of NLRP3 inflammasome by inhibiting P2X7R expression. [Abstract]2023 Feb;83(1):53-66. PMID: 36342791 -
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Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Swennen EL, et al. Immunoregulatory effects of adenosine 5'-triphosphate on cytokine release from stimulated whole blood. Eur J Immunol. 2005 Mar;35(3):852-8. [Content Brief]
[2]. M J L Bours, et al. Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther. 2006 Nov;112(2):358-404. [Content Brief]
[3]. Shuo Xu, et al. Doxycycline inhibits NAcht Leucine-rich repeat Protein 3 inflammasome activation and interleukin-1β production induced by Porphyromonas gingivalis-lipopolysaccharide and adenosine triphosphate in human gingival fibroblasts. Arch Oral Biol. 2019 Nov;107:104514. [Content Brief]
[4]. Yang Xiang, et al. Adenosine-5'-Triphosphate (ATP) Protects Mice against Bacterial Infection by Activation of the NLRP3 Inflammasome. PLoS One. 2013; 8(5): e63759. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)