ATP-13C10 dilithium
Based on 1 Customer Validation
ATP-13C10 (Adenosine 5'-triphosphate-ATP-13C10) dilithium is the 13C10-labeled ATP (HY-B2176). ATP is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation. ATP can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP has anti-bacterial infection effects and can protect mice against bacterial infection in mice.
The product specifications provided below refer solely to the active content of ATP-13C10 dilithium.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté : 99.97%
- Formule: 13C10H14Li2N5O13P3
- Masse moléculaire:528.97
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Stockage:
Solution, -20°C, 2 years
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
The product specifications provided below refer solely to the active content of ATP-13C10 dilithium.
IC50 & Target
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NLRP3 inflammasome |
IL-1β |
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled CAS 56-65-5
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Appearance Liquid
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Masse moléculaire 528.97
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Formule 13C10H14Li2N5O13P3
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Color Colorless to light yellow
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SMILES
O=P(O)(O[Li])OP(OP(O[13CH2][13C@H]1O[13C@@H](N2[13C]3=N[13CH]=N[13C](N)=[13C]3N=[13CH]2)[13C@H](O)[13C@@H]1O)(O)=O)(O[Li])=O
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Synonyms
Adenosine 5'-triphosphate-13C10 dilithium
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Solution, -20°C, 2 years
Solvant et solubilité
In Vitro:
H2O : ≥ 50 mg/mL (94.52 mM)
* "≥" means soluble, but saturation unknown.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Pureté et documentation
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Fiche technique (291 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Swennen EL, et al. Immunoregulatory effects of adenosine 5'-triphosphate on cytokine release from stimulated whole blood. Eur J Immunol. 2005 Mar;35(3):852-8. [Content Brief]
[2]. M J L Bours, et al. Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther. 2006 Nov;112(2):358-404. [Content Brief]
[3]. Shuo Xu, et al. Doxycycline inhibits NAcht Leucine-rich repeat Protein 3 inflammasome activation and interleukin-1β production induced by Porphyromonas gingivalis-lipopolysaccharide and adenosine triphosphate in human gingival fibroblasts. Arch Oral Biol. 2019 Nov;107:104514. [Content Brief]
[4]. Yang Xiang, et al. Adenosine-5'-Triphosphate (ATP) Protects Mice against Bacterial Infection by Activation of the NLRP3 Inflammasome. PLoS One. 2013; 8(5): e63759. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 1.8905 mL | 9.4523 mL | 18.9047 mL | 47.2617 mL |
| 5 mM | 0.3781 mL | 1.8905 mL | 3.7809 mL | 9.4523 mL | |
| 10 mM | 0.1890 mL | 0.9452 mL | 1.8905 mL | 4.7262 mL | |
| 15 mM | 0.1260 mL | 0.6302 mL | 1.2603 mL | 3.1508 mL | |
| 20 mM | 0.0945 mL | 0.4726 mL | 0.9452 mL | 2.3631 mL | |
| 25 mM | 0.0756 mL | 0.3781 mL | 0.7562 mL | 1.8905 mL | |
| 30 mM | 0.0630 mL | 0.3151 mL | 0.6302 mL | 1.5754 mL | |
| 40 mM | 0.0473 mL | 0.2363 mL | 0.4726 mL | 1.1815 mL | |
| 50 mM | 0.0378 mL | 0.1890 mL | 0.3781 mL | 0.9452 mL | |
| 60 mM | 0.0315 mL | 0.1575 mL | 0.3151 mL | 0.7877 mL | |
| 80 mM | 0.0236 mL | 0.1182 mL | 0.2363 mL | 0.5908 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
ATP-13C10 dilithium Related Classifications
HY-B2176S6 Related Classifications
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