1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. ATP dipotassium

ATP dipotassium (Synonyms: Adenosine 5'-triphosphate dipotassium)

Cat. No.: HY-B2176C
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ATP dipotassium (Adenosine 5'-triphosphate dipotassium) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP dipotassium is an important endogenous signaling molecule in immunity and inflammation.

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ATP dipotassium Chemical Structure

ATP dipotassium Chemical Structure

CAS No. : 42373-41-1

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Other In-stock Forms of ATP dipotassium:

ATP

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Description

ATP dipotassium (Adenosine 5'-triphosphate dipotassium) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP dipotassium is an important endogenous signaling molecule in immunity and inflammation[1][2].

In Vitro

ATP dipotassium (5mM; 1 hour) co-treatment with LPS (1 μg/ml) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs[3].
ATP dipotassium (2 mM; 0.5-24 hours) induces secretion of interleukin 1β, KC and MIP-2 from bone marrow derived macrophages (BMDMs) in vitro in a caspase-1 activation-dependent manner[4].
ATP dipotassium stimulats cytokine and chemokine secretion and inflammasome activation directly and indirectly induces in vitro neutrophil chemotaxis[4].

In Vivo

ATP dipotassium (50 mg/kg; i.p.) protects mice against bacterial infection in vivo[4].
ATP dipotassium induces the secretion of IL1β, KC and MIP-2 and neutrophils recruitment in vivo[4].

Animal Model: Four-week-old Kunming mice (18-22 g)[4]
Dosage: 50 mg/kg
Administration: Intraperitoneal injection, before bacterial (E. coli) challenge
Result: Protected mice from bacterial infection.
Molecular Weight

583.36

Formula

C₁₀H₁₄K₂N₅O₁₃P₃

CAS No.

42373-41-1

SMILES

O[[email protected]@H]([[email protected]]([[email protected]](N1C=NC2=C1N=CN=C2N)O3)O)[[email protected]]3COP(O)(OP(OP(O)(O[K])=O)(O[K])=O)=O

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Keywords:

ATP dipotassiumAdenosine 5'-triphosphate dipotassiumEndogenous MetaboliteenergystoragemetabolismimmunityinflammationNLRP3inflammasomecytokineInhibitorinhibitorinhibit

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ATP dipotassium
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HY-B2176C
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