1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. ATP disodium trihydrate

ATP disodium trihydrate (Synonyms: Adenosine-5'-triphosphate disodium trihydrate)

Cat. No.: HY-B2176A Purity: 98.34%
Handling Instructions

ATP disodium trihydrate (Adenosine 5'-triphosphate disodium trihydrate) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium trihydrate is an important endogenous signaling molecule in immunity and inflammation.

For research use only. We do not sell to patients.

ATP disodium trihydrate Chemical Structure

ATP disodium trihydrate Chemical Structure

CAS No. : 51963-61-2

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Based on 7 publication(s) in Google Scholar

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Description

ATP disodium trihydrate (Adenosine 5'-triphosphate disodium trihydrate) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium trihydrate is an important endogenous signaling molecule in immunity and inflammation[1][2].

In Vitro

ATP disodium trihydrate (5mM; 1 hour) co-treatment with LPS (1 μg/ml) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs[3].
ATP disodium trihydrate (2 mM; 0.5-24 hours) induces secretion of interleukin 1β, KC and MIP-2 from bone marrow derived macrophages (BMDMs) in vitro in a caspase-1 activation-dependent manner[4].
ATP disodium trihydrate stimulats cytokine and chemokine secretion and inflammasome activation directly and indirectly induces in vitro neutrophil chemotaxis[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ATP disodium trihydrate (50 mg/kg; i.p.) protects mice against bacterial infection in vivo[4].
ATP disodium trihydrate induces the secretion of IL1β, KC and MIP-2 and neutrophils recruitment in vivo[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Four-week-old Kunming mice (18-22 g)[4]
Dosage: 50 mg/kg
Administration: Intraperitoneal injection, before bacterial (E. coli) challenge
Result: Protected mice from bacterial infection.
Molecular Weight

605.19

Formula

C₁₀H₂₀N₅Na₂O₁₆P₃

CAS No.

51963-61-2

SMILES

O[[email protected]@H]([[email protected]]([[email protected]](N1C=NC2=C1N=CN=C2N)O3)O)[[email protected]]3COP(O)(OP(OP([O-])([O-])=O)(O)=O)=O.[Na+].[Na+].O.O.O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 250 mg/mL (413.09 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6524 mL 8.2619 mL 16.5237 mL
5 mM 0.3305 mL 1.6524 mL 3.3047 mL
10 mM 0.1652 mL 0.8262 mL 1.6524 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

ATP disodiumAdenosine-5'-triphosphate disodiumEndogenous MetaboliteenergystoragemetabolismimmunityinflammationNLRP3inflammasomecytokineInhibitorinhibitorinhibit

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ATP disodium trihydrate
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