1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. ATP disodium trihydrate

ATP disodium trihydrate (Synonyms: Adenosine-5'-triphosphate disodium trihydrate)

Cat. No.: HY-B2176A Purity: 98.34%
Handling Instructions

ATP disodium trihydrate (Adenosine 5'-triphosphate disodium trihydrate) is a central component of energy storage and metabolism in vivo. ATP disodium trihydrate provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium trihydrate is an important endogenous signaling molecule in immunity and inflammation.

For research use only. We do not sell to patients.

ATP disodium trihydrate Chemical Structure

ATP disodium trihydrate Chemical Structure

CAS No. : 51963-61-2

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Customer Review

Based on 25 publication(s) in Google Scholar

Other Forms of ATP disodium trihydrate:

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Description

ATP disodium trihydrate (Adenosine 5'-triphosphate disodium trihydrate) is a central component of energy storage and metabolism in vivo. ATP disodium trihydrate provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium trihydrate is an important endogenous signaling molecule in immunity and inflammation[1][2].

In Vitro

ATP disodium trihydrate (5 mM; 1 hour) co-treatment with LPS (1 μg/mL) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs[3].
ATP disodium trihydrate (2 mM; 0.5-24 hours) induces secretion of IL-1β, KC and MIP-2 from BMDMs in a caspase-1 activation-dependent manner[4].
ATP disodium trihydrate promotes neutrophil chemotaxis in vitro[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ATP disodium trihydrate (50 mg/kg; i.p.) protects mice against bacterial infection in vivo[4].
ATP disodium trihydrate induces the secretion of IL-1β, KC and MIP-2 and neutrophils recruitment in vivo[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Four-week-old Kunming mice (18-22 g)[4]
Dosage: 50 mg/kg
Administration: Intraperitoneal injection, before bacterial (E. coli) challenge
Result: Protected mice from bacterial infection.
Clinical Trial
Molecular Weight

605.19

Formula

C10H20N5Na2O16P3

CAS No.
SMILES

O[[email protected]@H]([[email protected]]([[email protected]](N1C=NC2=C1N=CN=C2N)O3)O)[[email protected]]3COP(O)(OP(OP([O-])([O-])=O)(O)=O)=O.[Na+].[Na+].O.O.O

Structure Classification
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 250 mg/mL (413.09 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6524 mL 8.2619 mL 16.5237 mL
5 mM 0.3305 mL 1.6524 mL 3.3047 mL
10 mM 0.1652 mL 0.8262 mL 1.6524 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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ATP disodium trihydrate
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