1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. ATP disodium trihydrate

ATP disodium trihydrate  (Synonyms: Adenosine-5'-triphosphate disodium trihydrate)

Cat. No.: HY-B2176A Purity: ≥98.0%
COA Handling Instructions

ATP disodium trihydrate (Adenosine 5'-triphosphate disodium trihydrate) is a central component of energy storage and metabolism in vivo. ATP disodium trihydrate provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium trihydrate is an important endogenous signaling molecule in immunity and inflammation.

For research use only. We do not sell to patients.

ATP disodium trihydrate Chemical Structure

ATP disodium trihydrate Chemical Structure

CAS No. : 51963-61-2

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Solid + Solvent
10 mM * 1 mL in Water
ready for reconstitution
USD 66 In-stock
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10 mM * 1 mL in Water USD 66 In-stock
Solid
100 mg USD 60 In-stock
500 mg USD 96 In-stock
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Based on 51 publication(s) in Google Scholar

Other Forms of ATP disodium trihydrate:

Top Publications Citing Use of Products

50 Publications Citing Use of MCE ATP disodium trihydrate

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    ATP disodium trihydrate purchased from MedChemExpress. Usage Cited in: Transl Res. 2022.

    LPS/ATP treatment significantly promotes expression of NLRP3 and production of N-GSDMD in HAEC. HAEC are pretreated with LPS (500ng/ml) for 5 h and then stimulated with ATP (5 mM) for 1 h.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    ATP disodium trihydrate (Adenosine 5'-triphosphate disodium trihydrate) is a central component of energy storage and metabolism in vivo. ATP disodium trihydrate provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium trihydrate is an important endogenous signaling molecule in immunity and inflammation[1][2].

    IC50 & Target

    Human Endogenous Metabolite

     

    In Vitro

    ATP disodium trihydrate (5 mM; 1 hour) co-treatment with LPS (1 μg/mL) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs[3].
    ATP disodium trihydrate (2 mM; 0.5-24 hours) induces secretion of IL-1β, KC and MIP-2 from BMDMs in a caspase-1 activation-dependent manner[4].
    ATP disodium trihydrate promotes neutrophil chemotaxis in vitro[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    ATP disodium trihydrate (50 mg/kg; i.p.) protects mice against bacterial infection in vivo[4].
    ATP disodium trihydrate induces the secretion of IL-1β, KC and MIP-2 and neutrophils recruitment in vivo[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Four-week-old Kunming mice (18-22 g)[4]
    Dosage: 50 mg/kg
    Administration: Intraperitoneal injection, before bacterial (E. coli) challenge
    Result: Protected mice from bacterial infection.
    Molecular Weight

    605.19

    Formula

    C10H20N5Na2O16P3

    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=P(O[Na])(O[Na])OP(OP(OC[C@H]1O[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@H](O)[C@@H]1O)(O)=O)(O)=O.O.O.O

    Structure Classification
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    -20°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : 250 mg/mL (413.09 mM; Need ultrasonic)

    DMSO : 1 mg/mL (1.65 mM; ultrasonic and warming and heat to 80°C)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.6524 mL 8.2619 mL 16.5237 mL
    5 mM 0.3305 mL 1.6524 mL 3.3047 mL
    10 mM 0.1652 mL 0.8262 mL 1.6524 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  PBS

      Solubility: 50 mg/mL (82.62 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

    *All of the co-solvents are available by MedChemExpress (MCE).
    Purity & Documentation
    References
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    ATP disodium trihydrate Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    × = ×
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    Product Name:
    ATP disodium trihydrate
    Cat. No.:
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