1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. ATP disodium salt

ATP disodium salt (Synonyms: Adenosine 5'-triphosphate disodium salt; Disodium adenosine triphosphate)

Cat. No.: HY-B0345A Purity: >98.0%
Handling Instructions

ATP disodium salt (Adenosine 5'-triphosphate disodium salt) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt is an important endogenous signaling molecule in immunity and inflammation.

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ATP disodium salt Chemical Structure

ATP disodium salt Chemical Structure

CAS No. : 987-65-5

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Based on 4 publication(s) in Google Scholar

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Description

ATP disodium salt (Adenosine 5'-triphosphate disodium salt) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt is an important endogenous signaling molecule in immunity and inflammation[1][2].

In Vitro

ATP disodium salt (5mM; 1 hour) co-treatment with LPS (1 μg/ml) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs[3].
ATP disodium salt (2 mM; 0.5-24 hours) induces secretion of interleukin 1β, KC and MIP-2 from bone marrow derived macrophages (BMDMs) in vitro in a caspase-1 activation-dependent manner[4].
ATP disodium salt stimulats cytokine and chemokine secretion and inflammasome activation directly and indirectly induces in vitro neutrophil chemotaxis[4].

In Vivo

ATP disodium salt (50 mg/kg; i.p.) protects mice against bacterial infection in vivo[4].
ATP disodium salt induces the secretion of IL1β, KC and MIP-2 and neutrophils recruitment in vivo[4].

Animal Model: Four-week-old Kunming mice (18-22 g)[4]
Dosage: 50 mg/kg
Administration: Intraperitoneal injection, before bacterial (E. coli) challenge
Result: Protected mice from bacterial infection.
Clinical Trial
Molecular Weight

551.14

Formula

C₁₀H₁₄N₅Na₂O₁₃P₃

CAS No.

987-65-5

SMILES

O[[email protected]@H]([[email protected]]([[email protected]](N1C=NC2=C1N=CN=C2N)O3)O)[[email protected]]3COP(O)(OP(OP([O-])(O)=O)([O-])=O)=O.[Na+].[Na+]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (181.44 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8144 mL 9.0721 mL 18.1442 mL
5 mM 0.3629 mL 1.8144 mL 3.6288 mL
10 mM 0.1814 mL 0.9072 mL 1.8144 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

ATP disodiumAdenosine 5'-triphosphate disodiumDisodium adenosine triphosphateEndogenous MetaboliteenergystoragemetabolismimmunityinflammationNLRP3inflammasomecytokineInhibitorinhibitorinhibit

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ATP disodium salt
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