ATP disodium salt
Based on 150 publication(s) in Google Scholar
ATP disodium salt (Adenosine 5'-triphosphate disodium salt) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt is an important endogenous signaling molecule in immunity and inflammation.
For research use only. We do not sell to patients.
- Purity: 99.95%
- CAS No.: 987-65-5
- Formula: C10H14N5Na2O13P3
- Molecular Weight:551.14
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
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Publications Citing Use of MedChemExpress (MCE) ATP disodium salt
More- Signal Transduct Target Ther. 2026 Mar 12;11(1):90. [Abstract]
- Cell. 2025 Dec 11;188(25):7194-7205.e10. [Abstract]
- Cell. 2025 Jul 24;188(15):4025-4042.e20. [Abstract]
- Cell. 2025 Jul 10;188(14):3744-3756.e16. [Abstract]
- Nat Biomed Eng. 2026 Jan 7.
- Immunity. 2025 Sep 9;58(9):2320-2335.e9. [Abstract]
- Immunity. 2024 Mar 12;57(3):495-512.e11. [Abstract]
- Cell Res. 2025 Feb;35(2):97-116. [Abstract]
- Mol Cell. 2026 Jan 8;86(1):150-165.e9. [Abstract]
- Cancer Res. 2025 Jul 25. [Abstract]
- Mol Cell. 2023 Jun 15;83(12):2137-2147.e4. [Abstract]
- Mol Cell. 2022 Jun 2;82(11):2032-2049.e7. [Abstract]
- ACS Nano. 2023 Dec 12;17(23):23872-23888. [Abstract]
- Cell Death Differ. 2025 Nov 10. [Abstract]
- Cell Death Differ. 2022 Feb;29(2):439-450. [Abstract]
- Acta Pharm Sin B. 2026 Mar 10.
- Autophagy. 2025 Aug 16. [Abstract]
- Autophagy. 2025 Mar 28. [Abstract]
- Adv Sci (Weinh). 2025 Nov 11:e08957. [Abstract]
- Adv Sci (Weinh). 2025 Sep 26:e08991. [Abstract]
- Adv Sci (Weinh). 2025 Jun 10:e01532. [Abstract]
- J Adv Res. 2026 Mar 12:S2090-1232(26)00239-0. [Abstract]
- Protein Cell. 2022 Apr;13(4):281-301. [Abstract]
- Cell Discov. 2025 Apr 29;11(1):41. [Abstract]
- Carbohydr Polym. 2020 Jun 1;237:116163. [Abstract]
- J Hazard Mater. 2025 Dec 2:501:140687. [Abstract]
- Biosens Bioelectron. 2021 Apr 15;178:113025. [Abstract]
- Mater Today Bio. 2025 May 10:32:101838. [Abstract]
- Mater Today Bio. 2025 Feb 1:31:101539. [Abstract]
- Cancer Lett. 2024 Jul 29:217145. [Abstract]
- Burns Trauma. 2026 Jan 6.
- Cell Death Dis. 2023 Mar 1;14(3):174. [Abstract]
- Cell Death Dis. 2022 Oct 8;13(10):860. [Abstract]
- Cell Death Dis. 2021 Dec 14;12(12):1159. [Abstract]
- Cell Death Dis. 2020 Feb 18;11(2):132. [Abstract]
- Cell Death Dis. 2020 Jan 30;11(1):78. [Abstract]
- Crit Care. 2021 Oct 12;25(1):356. [Abstract]
- ACS Sens. 2026 Mar 27;11(3):1891-1907. [Abstract]
- Proc Natl Acad Sci U S A. 2025 Feb 25;122(8):e2424906122. [Abstract]
- Cell Commun Signal. 2025 Jul 8;23(1):327. [Abstract]
- Int J Biol Macromol. 2026 May:361:151905. [Abstract]
- Int J Biol Macromol. 2025 Dec 30;339(Pt 2):149976. [Abstract]
- Int J Biol Macromol. 2024 Apr 27;268(Pt 2):131779. [Abstract]
- Acta Pharmacol Sin. 2025 Jul 17. [Abstract]
- Acta Pharmacol Sin. 2025 Apr 7. [Abstract]
- Acta Pharmacol Sin. 2022 Aug;43(8):2016-2025. [Abstract]
- Phytomedicine. 2026 Jan 16:153:157839. [Abstract]
- Phytomedicine. 2025 Dec:149:157563. [Abstract]
- EMBO J. 2025 Aug 18. [Abstract]
- Phytomedicine. 2025 Jul:142:156698. [Abstract]
- Phytomedicine. 2024 Jan:123:155193. [Abstract]
- Phytomedicine.2023 Sep:118:154971. [Abstract]
- Free Radic Biol Med. 2025 Dec 22:245:98-114. [Abstract]
- J Orthop Translat. 2026 Jan 6.
- Br J Pharmacol. 2025 May 13. [Abstract]
- Biomed Pharmacother. 2025 Nov 12:193:118748. [Abstract]
- Biomed Pharmacother. 2025 Jun 17:189:118275. [Abstract]
- J Transl Med. 2024 Sep 27;22(1):871. [Abstract]
- Biomed Pharmacother. 2024 Jun 21:177:117006. [Abstract]
- Biomed Pharmacother. 2024 Jun 24:177:116952. [Abstract]
- Biomed Pharmacother. 2024 Jul 15:177:117111. [Abstract]
- Stem Cell Res Ther. 2025 May 1;16(1):222. [Abstract]
- Cell Rep. 2025 Nov 25;44(12):116620. [Abstract]
- Cell Rep. 2025 Jan 10;44(1):115203. [Abstract]
- Cell Rep. 2024 Sep 28;43(10):114794. [Abstract]
- Cell Rep. 2024 Jun 27;43(7):114402. [Abstract]
- Cell Rep. 2021 Aug 10;36(6):109516. [Abstract]
- J Med Chem. 2026 Apr 9;69(7):7663-7676. [Abstract]
- Anal Chem. 2025 May 13;97(18):9827-9835. [Abstract]
- Antioxidants (Basel). 2023 Jun 19;12(6):1304. [Abstract]
- Antioxidants (Basel). 2022 Nov 23;11(12):2315. [Abstract]
- Mol Med. 2025 Jun 16;31(1):240. [Abstract]
- J Agric Food Chem. 2024 Sep 25;72(38):20959-20973. [Abstract]
- Cancer Cell Int. 2023 May 9;23(1):87. [Abstract]
- Anal Chim Acta. 2021 Dec 15:1188:339180. [Abstract]
- Eur J Med Chem. 2026 May 5:309:118765. [Abstract]
- Transl Res. 2023 May:255:1-13. [Abstract]
- Biochem Pharmacol. 2026 Feb:244:117614. [Abstract]
- Biochem Pharmacol. 2025 Jul 17:117177. [Abstract]
- Biochem Pharmacol. 2025 Feb 12:234:116801. [Abstract]
- Biochem Pharmacol. 2024 Jun 19:116377. [Abstract]
- Cell Prolif. 2023 Sep;56(9):e13442. [Abstract]
- Am J Chin Med. 2025;53(2):501-522. [Abstract]
- J Ethnopharmacol. 2026 May 10:362:121370. [Abstract]
- J Ethnopharmacol. 2026 Mar 25:359:121046. [Abstract]
- J Ethnopharmacol. 2025 Jul 30;353(Pt A):120346. [Abstract]
- Food Funct. 2025 Jun 16;16(12):4731-4753. [Abstract]
- J Ethnopharmacol. 2024 Jun 28:328:118057. [Abstract]
- J Ethnopharmacol. 2024 Feb 10:320:117388. [Abstract]
- Life Sci. 2021 Apr 15:271:119192. [Abstract]
- Inflammation. 2025 Dec 20;49(1):11. [Abstract]
- Respir Res. 2024 Jul 30;25(1):291. [Abstract]
- Nutrients. 2021 Dec 14;13(12):4462. [Abstract]
- Int J Mol Sci. 2024 Sep 26;25(19):10366. [Abstract]
- Eur J Pharmacol. 2026 Mar 28:1019:178738. [Abstract]
- Int Immunopharmacol. 2025 Oct 22:167:115697. [Abstract]
- Int Immunopharmacol. 2025 Sep 5:165:115437. [Abstract]
- Int Immunopharmacol. 2025 Jan 18:148:114057. [Abstract]
- Int Immunopharmacol. 2024 Nov 2;143(Pt 3):113527. [Abstract]
- Eur J Pharmacol. 2023 May 15:947:175681. [Abstract]
- Int Immunopharmacol. 2023 Mar:116:109747. [Abstract]
- Eur J Pharmacol. 2022 Feb 5:916:174729. [Abstract]
- Immunotargets Ther. 2024 Dec 14:13:775-788. [Abstract]
- Structure. 2025 May 1;33(5):903-915.e5. [Abstract]
- Appl Microbiol Biotechnol. 2024 Jan 25;108(1):173. [Abstract]
- FEBS J. 2026 Mar 10. [Abstract]
- Exp Neurol. 2026 Feb:396:115537. [Abstract]
- J Cell Mol Med. 2025 Jan;29(2):e70338. [Abstract]
- Biochim Biophys Acta Mol Basis Dis. 2024 Jan;1870(1):166895. [Abstract]
- J Inflamm Res. 2025 Jul 19:18:9587-9608. [Abstract]
- Neurochem Int. 2025 Jul:187:105992. [Abstract]
- Neuromolecular Med. 2023 Jun;25(2):230-241. [Abstract]
- Aging (Albany NY). 2021 Sep 28;13(18):22588-22610. [Abstract]
- Aging (Albany NY). 2021 Mar 10;13(6):8588-8598. [Abstract]
- J Virol. 2023 Mar 30;97(3):e0000323. [Abstract]
- Biochim Biophys Acta Mol Cell Res. 2024 Mar 22;1871(4):119712. [Abstract]
- Biochim Biophys Acta Mol Cell Res. 2024 Jan;1871(1):119595. [Abstract]
- Heliyon. 2024 Sep 19;10(19):e38050. [Abstract]
- Reprod Biomed Online. 2024 Oct;49(4):104319. [Abstract]
- Front Neurosci. 2022 Jun 7;16:901688. [Abstract]
- J Dent Sci. 2025 Jul;20(3):1422-1435. [Abstract]
- Clin Oral Investig. 2023 Jun;27(6):2875-2885. [Abstract]
- Mol Immunol. 2024 May:169:86-98. [Abstract]
- Biochemistry. 2023 Dec 5;62(23):3396-3410. [Abstract]
- Bioorg Med Chem. 2021 Jan 1;29:115899. [Abstract]
- Oral Dis. 2021 Jul;27(5):1148-1160. [Abstract]
- Mol Biol Rep. 2026 Jan 3;53(1):250. [Abstract]
- Int J Biochem Cell Biol. 2026 Jan:190:106880. [Abstract]
- Vet Microbiol. 2025 Aug:307:110628. [Abstract]
- Placenta. 2025 May 22:167:204-215. [Abstract]
- Vet Sci. 2024 Dec 12;11(12):643. [Abstract]
- Biochem Biophys Res Commun. 2024 May 14:708:149814. [Abstract]
- Hypertens Pregnancy. 2026 Dec 31;45(1):2609374. [Abstract]
- Brain Mechanisms. 2025 Nov 21.
- Arch Oral Biol. 2019 Nov:107:104514. [Abstract]
- Cardiovasc Pathol. 2025 Jul 4:79:107750. [Abstract]
- Cytotechnology. 2025 Apr;77(2):66. [Abstract]
- Int J Dev Neurosci. 2023 Feb;83(1):53-66. [Abstract]
- bioRxiv. 2026 Jan 13.
- SSRN. 2024 Nov 19.
- Res Sq. 2024 Sep 22.
- Research Square Preprint. 2024 Apr 9.
- bioRxiv. 2024 Apr 21.
- Research Square Preprint. 2023 Sep 8.
- SSRN. 2023 May 12.
- SSRN. 6 Dec 2022.
- Research Square Preprint. 2022 May.
- Research Square Preprint. 2022 Feb.
- Research Square Preprint. 2021 Jul.
- Research Square Preprint. 2020 Dec.
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All Endogenous Metabolite Isoforms
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Biological Activity
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Human Endogenous Metabolite |
ATP disodium salt (5 mM; 1 hour) co-treatment with LPS (1 μg/ml) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs[3].
ATP disodium salt (2 mM; 0.5-24 hours) induces secretion of interleukin 1β, KC and MIP-2 from bone marrow derived macrophages (BMDMs) in vitro in a caspase-1 activation-dependent manner[4].
ATP disodium salt stimulats cytokine and chemokine secretion and inflammasome activation directly and indirectly induces in vitro neutrophil chemotaxis[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
ATP disodium salt induces the secretion of IL1β, KC and MIP-2 and neutrophils recruitment in vivo[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Four-week-old Kunming mice (18-22 g)[4]
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Dosage:50 mg/kg
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Administration:Intraperitoneal injection, before bacterial (E. coli) challenge
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Result:Protected mice from bacterial infection.
Chemical Information
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CAS No. 987-65-5
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Appearance Solid
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Molecular Weight 551.14
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Formula C10H14N5Na2O13P3
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Color White to off-white
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SMILES
O[C@H]1[C@@H](O)[C@H](N2C(N=CN=C3N)=C3N=C2)O[C@@H]1COP(OP(OP(O)([O-])=O)([O-])=O)(O)=O.[2Na+]
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Synonyms
Adenosine 5'-triphosphate disodium salt; Disodium adenosine triphosphate
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (150)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Cyclic guanosine monophosphate-protein kinase G signaling attenuates aortic valve calcification through ULK1-mediated autophagy. [Abstract]2026 Mar 12;11(1):90. PMID: 41820291 -
Cell
Structural basis for the concurrence of template recycling and RNA capping in SARS-CoV-2. [Abstract]2025 Dec 11;188(25):7194-7205.e10. PMID: 41130208 -
Cell
Proximity between LAG-3 and the T cell receptor guides suppression of T cell activation and autoimmunity. [Abstract]2025 Jul 24;188(15):4025-4042.e20. PMID: 40592325 -
Cell
Cyclic-dinucleotide-induced filamentous assembly of phospholipases governs broad CBASS immunity. [Abstract]2025 Jul 10;188(14):3744-3756.e16. PMID: 40345202 -
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Immunity
Spatiotemporal dynamics of CXCL10 encode contextual immune information revealed by the genetically encoded fluorescent sensor. [Abstract]2025 Sep 9;58(9):2320-2335.e9. PMID: 40818452 -
Immunity
Disruption of the Na+/K+-ATPase-purinergic P2X7 receptor complex in microglia promotes stress-induced anxiety. [Abstract]2024 Mar 12;57(3):495-512.e11. PMID: 38395698
ATP disodium salt purchased from MedChemExpress. Usage Cited in: Immunity. 2024 Mar 12;57(3):495-512.e11. [Abstract]
Representative western blots and analyses of the following proteins in BV2 cells treated with vehicle (Con), LPS (200 ng/ml, 3 h), LPS + ATP (3 mM, 30 min), or LPS + ATP-siNKAα1.
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Cell Res
Nonenzymatic lysine D-lactylation induced by glyoxalase II substrate SLG dampens inflammatory immune responses. [Abstract]2025 Feb;35(2):97-116. PMID: 39757301 -
Mol Cell
Mitochondrial glutamine import sustains electron transport chain integrity independently of glutaminolysis in cancer. [Abstract]2026 Jan 8;86(1):150-165.e9. PMID: 41435838 -
Cancer Res
Mitochondrial Calcium Uniporter Links Acetyl-CoA Metabolism and H3K27 Acetylation to Maintain Glioblastoma Stem Cells. [Abstract]2025 Jul 25. PMID: 40712058 -
Mol Cell
2023 Jun 15;83(12):2137-2147.e4. PMID: 37244256 -
Mol Cell
Cytoplasmic PARP1 links the genome instability to the inhibition of antiviral immunity through PARylating cGAS. [Abstract]2022 Jun 2;82(11):2032-2049.e7. PMID: 35460603 -
ACS Nano
2023 Dec 12;17(23):23872-23888. PMID: 38084420 -
Cell Death Differ
OR2T6 modulates autophagy through the PPP3CA-mediated pathways to suppress gastric cancer. [Abstract]2025 Nov 10. PMID: 41214150 -
Cell Death Differ
2022 Feb;29(2):439-450. PMID: 34511601
ATP disodium salt purchased from MedChemExpress. Usage Cited in: Cell Death Differ. 2022 Feb;29(2):439-450. [Abstract]
Primary BMDM cells were isolated from WT and Trim21-/- C57BL/6 mice. Cells were primed with 1 μg/mL LPS for 2 h followed by 5 mM ATP or 20 μM Nig or 30 μM flagellin for 30 min. Cell viability are determined by the Cell Counting Kit-8.
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Autophagy
Inhibition of UBE2N promotes the clearance of mutant HTT (huntingtin) in HD knock-in mice. [Abstract]2025 Aug 16. PMID: 40818063 -
Autophagy
ESCRT III-mediated lysosomal repair improve renal tubular cell injury in cisplatin-induced AKI. [Abstract]2025 Mar 28. PMID: 40152606 -
Adv Sci (Weinh)
Mitochondrial CISD1 Modulates Microglial Metabolic Reprogramming to Drive Stress Susceptibility in Mice. [Abstract]2025 Nov 11:e08957. PMID: 41215712 -
Adv Sci (Weinh)
Acetylation of the Mitochondrial Chaperone GRP75 Governs ER-Mitochondrial Calcium Homeostasis and Hepatocyte Insulin Resistance. [Abstract]2025 Sep 26:e08991. PMID: 41001747 -
Adv Sci (Weinh)
2025 Jun 10:e01532. PMID: 40492417 -
J Adv Res
Conjugated bile acids facilitate cholangiocyte senescence to promote cholestatic liver diseases via STING signaling. [Abstract]2026 Mar 12:S2090-1232(26)00239-0. PMID: 41831676 -
Protein Cell
Drug target inference by mining transcriptional data using a novel graph convolutional network framework. [Abstract]2022 Apr;13(4):281-301. PMID: 34677780 -
Cell Discov
2025 Apr 29;11(1):41. PMID: 40301304 -
Carbohydr Polym
The effect of doxycycline-containing chitosan/carboxymethyl chitosan nanoparticles on NLRP3 inflammasome in periodontal disease. [Abstract]2020 Jun 1;237:116163. PMID: 32241426 -
J Hazard Mater
Protection against deoxynivalenol (DON)-induced intestinal injury by sulforaphane via modulation of lysosomal function. [Abstract]2025 Dec 2:501:140687. PMID: 41352012 -
Biosens Bioelectron
2021 Apr 15;178:113025. PMID: 33529860 -
Mater Today Bio
Nanotube topography inhibits NLRP3 inflammasome activation by reducing microtubule glutamylation. [Abstract]2025 May 10:32:101838. PMID: 40487178 -
Mater Today Bio
Nature-derived microneedles with metal-polyphenolic networks encapsulation for chronic soft tissue defects repair: Responding and remodeling the regenerative microenvironment. [Abstract]2025 Feb 1:31:101539. PMID: 40026624 -
Cancer Lett
Sulforaphane suppresses bladder cancer metastasis via blocking actin nucleation-mediated pseudopodia formation. [Abstract]2024 Jul 29:217145. PMID: 39084455 -
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Cell Death Dis
Honokiol suppresses the aberrant interactions between renal resident macrophages and tubular epithelial cells in lupus nephritis through the NLRP3/IL-33/ST2 axis. [Abstract]2023 Mar 1;14(3):174. PMID: 36859530 -
Cell Death Dis
Inhibition of p38 MAPK or immunoproteasome overcomes resistance of chronic lymphocytic leukemia cells to Bcl-2 antagonist venetoclax. [Abstract]2022 Oct 8;13(10):860. PMID: 36209148 -
Cell Death Dis
2021 Dec 14;12(12):1159. PMID: 34907173 -
Cell Death Dis
Silencing lncRNA Lfar1 alleviates the classical activation and pyoptosis of macrophage in hepatic fibrosis. [Abstract]2020 Feb 18;11(2):132. PMID: 32071306
ATP disodium salt purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2020 Feb 18;11(2):132. [Abstract]
KCs were stimulated with 100 ng/mL LPS for 4 hours and subsequently treated them with 5 mM ATP for 2 hours to induce pyroptosis. The RNA level of lnc-Lfar1 was determined by qRT-PCR.
ATP disodium salt purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2020 Feb 18;11(2):132. [Abstract]
KCs were transfected with lnc-Lfar1 siRNA for 24 h, followed by stimulation with 100 ng/ml LPS for 4 h and subsequently treated with 5 mM ATP or 100 ng/ml for 2 h to induce pyroptosis. a, b The protein level of NLRP3, Caspase1 and GSDMD was determined by western blot. GAPDH was used as an internal control.
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Cell Death Dis
Lipoxin A4 suppresses angiotensin II type 1 receptor autoantibody in preeclampsia via modulating caspase-1. [Abstract]2020 Jan 30;11(1):78. PMID: 32001671 -
Crit Care
Exosomal miR-30d-5p of neutrophils induces M1 macrophage polarization and primes macrophage pyroptosis in sepsis-related acute lung injury. [Abstract]2021 Oct 12;25(1):356. PMID: 34641966
ATP disodium salt purchased from MedChemExpress. Usage Cited in: Crit Care. 2021 Oct 12;25(1):356. [Abstract]
Stimulation of Raw264.7 macrophages with PBS/PBS-Exo/TNF-Exo for 24 h and treatment with PBS, 5 mM ATP or 20 mM nigericin for 2 h. Cleavage of GSDMD by western blot. GSDMD-FL: full-length GSDMD, GSDMD-N: N-terminal cleavage products of GSDMD.
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ACS Sens
A Sensitive Green-Red FRET Sensor for Calpain-1 Utilizing Heterodimeric Fluorescent Proteins from Distinct Evolutionary Origins. [Abstract]2026 Mar 27;11(3):1891-1907. PMID: 41837894 -
Proc Natl Acad Sci U S A
Stepwise activation of SARM1 for cell death and axon degeneration revealed by a biosynthetic NMN mimic. [Abstract]2025 Feb 25;122(8):e2424906122. PMID: 39964720 -
Cell Commun Signal
JC124 confers multimodal neuroprotection in epilepsy by suppressing NLRP3 inflammasome activation: evidence from animal and human neuronal models. [Abstract]2025 Jul 8;23(1):327. PMID: 40629339 -
Int J Biol Macromol
NIM5 series brain-penetrant NLRP3 inflammasome inhibitors suppress neuroinflammation in EAE and Alzheimer's models. [Abstract]2026 May:361:151905. PMID: 41962712 -
Int J Biol Macromol
2025 Dec 30;339(Pt 2):149976. PMID: 41478474 -
Int J Biol Macromol
2024 Apr 27;268(Pt 2):131779. PMID: 38679250 -
Acta Pharmacol Sin
Identification of AKOS, a Chikungunya virus inhibitor, as a USP14 inhibitor for colorectal cancer treatment. [Abstract]2025 Jul 17. PMID: 40676218 -
Acta Pharmacol Sin
Direct inhibition of the TXNIP-NLRP3-GSDMD pathway reduces pyroptosis in colonocytes and alleviates ulcerative colitis in mice by the small compound PEITC. [Abstract]2025 Apr 7. PMID: 40195510 -
Acta Pharmacol Sin
Sapidolide A alleviates acetaminophen-induced acute liver injury by inhibiting NLRP3 inflammasome activation in macrophages. [Abstract]2022 Aug;43(8):2016-2025. PMID: 35022542 -
Phytomedicine
Isodeoxyelephantopin mitigates DSS-induced ulcerative colitis by suppressing IL-1β-driven inflammation via the TXNIP/NLRP3 axis. [Abstract]2026 Jan 16:153:157839. PMID: 41655542 -
Phytomedicine
Sclareol alleviates synovial inflammation in knee osteoarthritis by regulating sphingolipid metabolism along the gut-bone axis. [Abstract]2025 Dec:149:157563. PMID: 41273871 -
EMBO J
Speedy A governs non-homologous XY chromosome desynapsis as a unique prerequisite for XY loop-axis organization. [Abstract]2025 Aug 18. PMID: 40826181 -
Phytomedicine
Ophiopogonin C protects against acute lung injury by fatal sepsis through pyroptosis macrophage. [Abstract]2025 Jul:142:156698. PMID: 40397999 -
Phytomedicine
Lupeol alleviates autoimmune myocarditis by suppressing macrophage pyroptosis and polarization via PPARα/LACC1/NF-κB signaling pathway. [Abstract]2024 Jan:123:155193. PMID: 37976692 -
Phytomedicine
Geniposide alleviated bile acid-associated NLRP3 inflammasome activation by regulating SIRT1/FXR signaling in bile duct ligation-induced liver fibrosis. [Abstract]2023 Sep:118:154971. PMID: 37494875 -
Free Radic Biol Med
Paeoniflorin mitigates myocardial hypertrophy by regulating mitophagy and ferroptosis mediated by mitochondria-associated AMPK-Parkin-ACSL4 pathway. [Abstract]2025 Dec 22:245:98-114. PMID: 41443335 -
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Br J Pharmacol
Contributions of synaptic energetic dysfunction by microtubule dynamics and microtubule-based mitochondrial transport disorder to morphine tolerance. [Abstract]2025 May 13. PMID: 40361281 -
Biomed Pharmacother
Docking and database screening identify manidipine as a potential modulator of matrix metalloproteinase-7 in chronic kidney disease. [Abstract]2025 Nov 12:193:118748. PMID: 41232355 -
Biomed Pharmacother
Cilostazol attenuates vascular inflammation via the regulation of TICAM1/IRF3 signaling pathway. [Abstract]2025 Jun 17:189:118275. PMID: 40532577 -
J Transl Med
Vascular restenosis following paclitaxel-coated balloon therapy is attributable to NLRP3 activation and LIN9 upregulation. [Abstract]2024 Sep 27;22(1):871. PMID: 39334121 -
Biomed Pharmacother
Ginkgolide B effectively mitigates neuropathic pain by suppressing the activation of the NLRP3 inflammasome through the induction of mitophagy in rats. [Abstract]2024 Jun 21:177:117006. PMID: 38908197 -
Biomed Pharmacother
Gentiopicroside improves NASH and liver fibrosis by suppressing TLR4 and NLRP3 signaling pathways. [Abstract]2024 Jun 24:177:116952. PMID: 38917754 -
Biomed Pharmacother
Bongkrekic acid alleviates airway inflammation via breaking the mPTP/mtDAMPs/RAGE feedback loop in a steroid-insensitive asthma model. [Abstract]2024 Jul 15:177:117111. PMID: 39013220 -
Stem Cell Res Ther
Enhance the therapeutic efficacy of human umbilical cord-derived mesenchymal stem cells in prevention of acute graft-versus-host disease through CRISPLD2 modulation. [Abstract]2025 May 1;16(1):222. PMID: 40312744 -
Cell Rep
Glutamine synthetase modulates YAP activation by stabilizing LATS under glutamine homeostasis. [Abstract]2025 Nov 25;44(12):116620. PMID: 41296569 -
Cell Rep
Ergosterol alleviates hepatic steatosis and insulin resistance via promoting fatty acid β-oxidation by activating mitochondrial ACSL1. [Abstract]2025 Jan 10;44(1):115203. PMID: 39799570 -
Cell Rep
Mitotic ER-mitochondria contact enhances mitochondrial Ca2+ influx to promote cell division. [Abstract]2024 Sep 28;43(10):114794. PMID: 39342616 -
Cell Rep
Translocational attenuation mediated by the PERK-SRP14 axis is a protective mechanism of unfolded protein response. [Abstract]2024 Jun 27;43(7):114402. PMID: 38943644 -
Cell Rep
NAD+ supplement potentiates tumor-killing function by rescuing defective TUB-mediated NAMPT transcription in tumor-infiltrated T cells. [Abstract]2021 Aug 10;36(6):109516. PMID: 34380043 -
J Med Chem
Platinum-Paeonol Complexes as ERK Inhibitors To Restrain Melanoma and Relieve Cancer Pain. [Abstract]2026 Apr 9;69(7):7663-7676. PMID: 41873204 -
Anal Chem
Ultrahigh Flow Regulated Discharge Coupling with Targeted Mass Spectrometry Analysis: Real Time Capturing Biomolecules in Exhaled Breath. [Abstract]2025 May 13;97(18):9827-9835. PMID: 40302637 -
Antioxidants (Basel)
2023 Jun 19;12(6):1304. PMID: 37372033 -
Antioxidants (Basel)
Blocking TRPV4 Ameliorates Osteoarthritis by Inhibiting M1 Macrophage Polarization via the ROS/NLRP3 Signaling Pathway. [Abstract]2022 Nov 23;11(12):2315. PMID: 36552524 -
Mol Med
4-Octyl itaconate alleviates endothelial cell inflammation and barrier dysfunction in LPS-induced sepsis via modulating TLR4/MAPK/NF-κB signaling : 4-Octyl itaconate alleviates endothelial dysfunction. [Abstract]2025 Jun 16;31(1):240. PMID: 40524158 -
J Agric Food Chem
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ATP disodium salt purchased from MedChemExpress. Usage Cited in: Transl Res. 2023 May:255:1-13. [Abstract]
LPS/ATP treatment significantly promotes expression of NLRP3 and production of N-GSDMD in HAEC. HAEC are pretreated with LPS (500ng/ml) for 5 h and then stimulated with ATP (5 mM) for 1 h.
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Arch Oral Biol
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Solvent & Solubility
H2O : 100 mg/mL (181.44 mM; Need ultrasonic)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (181.44 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (278 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Bonora M, et al. ATP synthesis and storage. Purinergic Signal. 2012 Sep;8(3):343-57. [Content Brief]
[2]. M J L Bours, et al. Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther. 2006 Nov;112(2):358-404. [Content Brief]
[3]. Shuo Xu, et al. Doxycycline inhibits NAcht Leucine-rich repeat Protein 3 inflammasome activation and interleukin-1β production induced by Porphyromonas gingivalis-lipopolysaccharide and adenosine triphosphate in human gingival fibroblasts. Arch Oral Biol. 2019 Nov;107:104514. [Content Brief]
[4]. Yang Xiang, et al. Adenosine-5'-Triphosphate (ATP) Protects Mice against Bacterial Infection by Activation of the NLRP3 Inflammasome. PLoS One. 2013; 8(5): e63759. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.8144 mL | 9.0721 mL | 18.1442 mL | 45.3605 mL |
| 5 mM | 0.3629 mL | 1.8144 mL | 3.6288 mL | 9.0721 mL | |
| 10 mM | 0.1814 mL | 0.9072 mL | 1.8144 mL | 4.5361 mL | |
| 15 mM | 0.1210 mL | 0.6048 mL | 1.2096 mL | 3.0240 mL | |
| 20 mM | 0.0907 mL | 0.4536 mL | 0.9072 mL | 2.2680 mL | |
| 25 mM | 0.0726 mL | 0.3629 mL | 0.7258 mL | 1.8144 mL | |
| 30 mM | 0.0605 mL | 0.3024 mL | 0.6048 mL | 1.5120 mL | |
| 40 mM | 0.0454 mL | 0.2268 mL | 0.4536 mL | 1.1340 mL | |
| 50 mM | 0.0363 mL | 0.1814 mL | 0.3629 mL | 0.9072 mL | |
| 60 mM | 0.0302 mL | 0.1512 mL | 0.3024 mL | 0.7560 mL | |
| 80 mM | 0.0227 mL | 0.1134 mL | 0.2268 mL | 0.5670 mL | |
| 100 mM | 0.0181 mL | 0.0907 mL | 0.1814 mL | 0.4536 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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