2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. ATP disodium salt

ATP disodium salt  (Synonyms: Adenosine 5'-triphosphate disodium salt; Disodium adenosine triphosphate)

Cat. No.: HY-B0345A Purity: ≥98.0%
COA Handling Instructions

ATP disodium salt (Adenosine 5'-triphosphate disodium salt) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt is an important endogenous signaling molecule in immunity and inflammation.

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ATP disodium salt Chemical Structure

ATP disodium salt Chemical Structure

CAS No. : 987-65-5

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Customer Review

Based on 36 publication(s) in Google Scholar

Other Forms of ATP disodium salt:

Top Publications Citing Use of Products

35 Publications Citing Use of MCE ATP disodium salt

WB

    ATP disodium salt purchased from MCE. Usage Cited in: Transl Res. 2022.

    LPS/ATP treatment significantly promotes expression of NLRP3 and production of N-GSDMD in HAEC. HAEC are pretreated with LPS (500ng/ml) for 5 h and then stimulated with ATP (5 mM) for 1 h.

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    Description

    ATP disodium salt (Adenosine 5'-triphosphate disodium salt) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt is an important endogenous signaling molecule in immunity and inflammation[1][2].

    IC50 & Target

    Human Endogenous Metabolite

     

    In Vitro

    ATP disodium salt (5mM; 1 hour) co-treatment with LPS (1 μg/ml) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs[3].
    ATP disodium salt (2 mM; 0.5-24 hours) induces secretion of interleukin 1β, KC and MIP-2 from bone marrow derived macrophages (BMDMs) in vitro in a caspase-1 activation-dependent manner[4].
    ATP disodium salt stimulats cytokine and chemokine secretion and inflammasome activation directly and indirectly induces in vitro neutrophil chemotaxis[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    In Vivo

    ATP disodium salt (50 mg/kg; i.p.) protects mice against bacterial infection in vivo[4].
    ATP disodium salt induces the secretion of IL1β, KC and MIP-2 and neutrophils recruitment in vivo[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Four-week-old Kunming mice (18-22 g)[4]
    Dosage: 50 mg/kg
    Administration: Intraperitoneal injection, before bacterial (E. coli) challenge
    Result: Protected mice from bacterial infection.
    Clinical Trial
    Molecular Weight

    551.14

    Appearance

    Solid

    Formula

    C10H14N5Na2O13P3
    CAS No.
    SMILES

    O[[email protected]]1[[email protected]@H](O)[[email protected]](N2C(N=CN=C3N)=C3N=C2)O[[email protected]@H]1COP(OP(OP(O)([O-])=O)([O-])=O)(O)=O.[2Na+]
    Structure Classification
    Source

    Widespread
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
    Solvent & Solubility
    In Vitro: 

    H2O : 100 mg/mL (181.44 mM; Need ultrasonic)

    DMSO : 1 mg/mL (1.81 mM; ultrasonic and warming and heat to 80°C)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.8144 mL 9.0721 mL 18.1442 mL
    5 mM 0.3629 mL 1.8144 mL 3.6288 mL
    10 mM 0.1814 mL 0.9072 mL 1.8144 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (181.44 mM); Clear solution; Need ultrasonic

    *All of the co-solvents are available by MCE.
    Purity & Documentation

    Purity: ≥98.0%

    COA (251 KB) HNMR (273 KB)

    Handling Instructions (2659 KB)
    References
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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Keywords:

    ATP disodium987-65-5Adenosine 5'-triphosphate disodium Disodium adenosine triphosphateEndogenous MetaboliteenergystoragemetabolismimmunityinflammationNLRP3inflammasomecytokineInhibitorinhibitorinhibit

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