TRPV4 drives macrophage pyroptosis via mitochondrial dysfunction and mtROS-dependent NLRP3 inflammasome activation in acute lung injury

  • Redox Biol. 2026 Jun 11:95:104255. doi: 10.1016/j.redox.2026.104255.
Lan Luo  1 ,  Xiaofang Yang  2 ,  Shuyuan Yi  2 ,  Ziyuan Dong  2 ,  Kan Wang  2 ,  Zicheng Zhu  2 ,  Qian Gao  2 ,  Jianxue Gao  2 ,  Yu Jiang  2 ,  Ming Gong  3 ,  Hongjia Zhang  4 ,  Meili Wang  5 ,  Feilong Hei  6
Affiliations
  • 1. Department of Extracorporeal Circulation and Mechanical Circulation Assistants, Center for Cardiac Intensive Care, Beijing Anzhen Hospital, Capital Medical University, No. 2 Anzhen Road, Chaoyang District, Beijing, 100029, China; Department of Anesthesiology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610072, China; Beijing Lab for Cardiovascular Precision Medicine, Capital Medical University, Beijing, 100069, China.
  • 2. Department of Extracorporeal Circulation and Mechanical Circulation Assistants, Center for Cardiac Intensive Care, Beijing Anzhen Hospital, Capital Medical University, No. 2 Anzhen Road, Chaoyang District, Beijing, 100029, China.
  • 3. Beijing Lab for Cardiovascular Precision Medicine, Capital Medical University, Beijing, 100069, China; Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, No. 2 Anzhen Road, Chaoyang District, Beijing, 100029, China. Electronic address: [email protected].
  • 4. Beijing Lab for Cardiovascular Precision Medicine, Capital Medical University, Beijing, 100069, China; Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, No. 2 Anzhen Road, Chaoyang District, Beijing, 100029, China. Electronic address: [email protected].
  • 5. Beijing Lab for Cardiovascular Precision Medicine, Capital Medical University, Beijing, 100069, China; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China. Electronic address: [email protected].
  • 6. Department of Extracorporeal Circulation and Mechanical Circulation Assistants, Center for Cardiac Intensive Care, Beijing Anzhen Hospital, Capital Medical University, No. 2 Anzhen Road, Chaoyang District, Beijing, 100029, China. Electronic address: [email protected].
PMID: 42314332 DOI: 10.1016/j.redox.2026.104255
Abstract

Created in BioRender. Luo, L. (2026) https://BioRender.com/dd42nkh . [Figure: see text]

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