ATP disodium salt hydrate  (Synonyms: Adenosine 5'-triphosphate disodium salt hydrate)

ATP disodium salt hydrate (Adenosine 5'-triphosphatedisodium salt hydrate) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt hydrate is an important endogenous signaling molecule in immunity and inflammation^[1][2].

ATP disodium salt hydrate (5mM; 1 hour) co-treatment with LPS (1 μg/ml) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs^[3].
ATP disodium salt hydrate (2 mM; 0.5-24 hours) induces secretion of interleukin 1β, KC and MIP-2 from bone marrow derived macrophages (BMDMs) in vitro in a caspase-1 activation-dependent manner^[4].
ATP disodium salt hydrate stimulats cytokine and chemokine secretion and inflammasome activation directly and indirectly induces in vitro neutrophil chemotaxis^[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ATP disodium salt hydrate (50 mg/kg; i.p.) protects mice against bacterial infection in vivo^[4].
ATP disodium salt hydrate induces the secretion of IL1β, KC and MIP-2 and neutrophils recruitment in vivo^[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Solid

C₁₀H₁₆N₅O₁₃Na₂P₃.xH₂O

34369-07-8

O[[email protected]@H]([[email protected]]([[email protected]](N1C=NC2=C(N=CN=C21)N)O3)O)[[email protected]]3COP(O)(OP(OP(O)(O[Na])=O)(O[Na])=O)=O.[H]O[H].[x]

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Bonora M, et al. ATP synthesis and storage. Purinergic Signal. 2012 Sep;8(3):343-57.  [Content Brief]

  [2]. M J L Bours, et al. Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther. 2006 Nov;112(2):358-404.  [Content Brief]

  [3]. Shuo Xu, et al. Doxycycline inhibits NAcht Leucine-rich repeat Protein 3 inflammasome activation and interleukin-1β production induced by Porphyromonas gingivalis-lipopolysaccharide and adenosine triphosphate in human gingival fibroblasts. Arch Oral Biol.  [Content Brief]

  [4]. Yang Xiang, et al. Adenosine-5'-Triphosphate (ATP) Protects Mice against Bacterial Infection by Activation of the NLRP3 Inflammasome. PLoS One. 2013; 8(5): e63759.  [Content Brief]