1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. ATP disodium salt hydrate

ATP disodium salt hydrate (Synonyms: Adenosine 5'-triphosphate disodium salt hydrate)

Cat. No.: HY-W010735
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ATP disodium salt hydrate (Adenosine 5'-triphosphatedisodium salt hydrate) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt hydrate is an important endogenous signaling molecule in immunity and inflammation.

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ATP disodium salt hydrate Chemical Structure

ATP disodium salt hydrate Chemical Structure

CAS No. : 34369-07-8

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Description

ATP disodium salt hydrate (Adenosine 5'-triphosphatedisodium salt hydrate) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt hydrate is an important endogenous signaling molecule in immunity and inflammation[1][2].

In Vitro

ATP disodium salt hydrate (5mM; 1 hour) co-treatment with LPS (1 μg/ml) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs[3].
ATP disodium salt hydrate (2 mM; 0.5-24 hours) induces secretion of interleukin 1β, KC and MIP-2 from bone marrow derived macrophages (BMDMs) in vitro in a caspase-1 activation-dependent manner[4].
ATP disodium salt hydrate stimulats cytokine and chemokine secretion and inflammasome activation directly and indirectly induces in vitro neutrophil chemotaxis[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ATP disodium salt hydrate (50 mg/kg; i.p.) protects mice against bacterial infection in vivo[4].
ATP disodium salt hydrate induces the secretion of IL1β, KC and MIP-2 and neutrophils recruitment in vivo[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Four-week-old Kunming mice (18-22 g)[4]
Dosage: 50 mg/kg
Administration: Intraperitoneal injection, before bacterial (E. coli) challenge
Result: Protected mice from bacterial infection.
Clinical Trial
Formula

C₁₀H₁₆N₅O₁₃Na₂P₃.xH₂O

CAS No.
SMILES

O[[email protected]@H]([[email protected]]([[email protected]](N1C=NC2=C(N=CN=C21)N)O3)O)[[email protected]]3COP(O)(OP(OP(O)(O[Na])=O)(O[Na])=O)=O.[H]O[H].[x]

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Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
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Keywords:

ATP disodium saltAdenosine 5'-triphosphate disodium saltEndogenous MetaboliteenergystoragemetabolismimmunityinflammationNLRP3inflammasomecytokineInhibitorinhibitorinhibit

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ATP disodium salt hydrate
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