2. Cytoskeleton Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. Exosomes Endogenous Metabolite DNA/RNA Synthesis
  4. Guanosine 5'-triphosphate trisodium

Guanosine 5'-triphosphate trisodium  (Synonyms: 5'-GTP trisodium)

Cat. No.: HY-12695 Purity: 95.0%
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Guanosine 5'-triphosphate (5'-GTP) trisodium salt is a G protein (G proteins) signaling activator and a high-energy precursor in the biosynthesis of nucleotide units in DNA and RNA. Guanosine 5'-triphosphate trisodium salt can promote myogenic cell differentiation by upregulating miRNA (miR133a, miR133b) and myogenic regulatory factor expression, and by inducing human myogenic precursor cells to release exosomes containing guanosine molecules. Guanosine-5'-triphosphate trisodium salt holds promise for research in biosynthesis and skeletal muscle regeneration.

For research use only. We do not sell to patients.

CAS No. : 36051-31-7

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Based on 5 publication(s) in Google Scholar

Other Forms of Guanosine 5'-triphosphate trisodium:

Guanosine 5'-triphosphate trisodium Related Antibodies

Top Publications Citing Use of Products

    Guanosine 5'-triphosphate trisodium purchased from MedChemExpress. Usage Cited in: J Biol Chem. 2026 Jan 28:111214.

    Guanosine 5'-triphosphate trisodium (GTP) (0-100 μM) induced the highest maximum SAMHD1 dNTPase activity.

    Guanosine 5'-triphosphate trisodium purchased from MedChemExpress. Usage Cited in: J Biol Chem. 2026 Jan 28:111214.

    Guanosine 5'-triphosphate trisodium (GTP) (5-1200 μM) effectively induced tetramerization of the recombinant SAMHD1 protein in a dose-dependent manner.

    Guanosine 5'-triphosphate trisodium purchased from MedChemExpress. Usage Cited in: J Biol Chem. 2026 Jan 28:111214.

    High-confidence fits were obtained for the Guanosine 5'-triphosphate trisodium (GTP) (250 μM; 25 min)-activated hydrolysis of dATP.

    Guanosine 5'-triphosphate trisodium purchased from MedChemExpress. Usage Cited in: J Biol Chem. 2026 Jan 28:111214.

    In the absence of competitors, increasing Guanosine 5'-triphosphate trisodium (GTP) (0-50 μM) preincubation concentrations led to increasing activity. Guanosine 5'-triphosphate trisodium (GTP) added at the reaction start further increased SAMHD1 activity.

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    Description

    Guanosine 5'-triphosphate (5'-GTP) trisodium salt is a G protein (G proteins) signaling activator and a high-energy precursor in the biosynthesis of nucleotide units in DNA and RNA. Guanosine 5'-triphosphate trisodium salt can promote myogenic cell differentiation by upregulating miRNA (miR133a, miR133b) and myogenic regulatory factor expression, and by inducing human myogenic precursor cells to release exosomes containing guanosine molecules. Guanosine-5'-triphosphate trisodium salt holds promise for research in biosynthesis and skeletal muscle regeneration[1].

    IC50 & Target

    Human Endogenous Metabolite

     

    In Vitro

    Guanosine-5'-triphosphate trisodium salt (500 μM, 24 h) significantly upregulates the expression of miR133a, miR133b, and the myogenic regulatory factor Myogenin in differentiated human myogenic precursor cells (MPCs)[1].
    Guanosine-5'-triphosphate trisodium salt (500 μM, 24 h) can induce the release of exosomes from human myogenic precursor cells[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Guanosine 5'-triphosphate trisodium Related Antibodies

    RT-PCR[1]

    Cell Line: Human myogenic precursor cells (MPCs)
    Concentration: 500 μM
    Incubation Time: 24 h
    Result: Significantly upregulated Myogenin gene expression.
    Molecular Weight

    589.13

    Formula

    C10H13N5Na3O14P3
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=P(OP(OP(O)(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=NC3=C2NC(N)=NC3=O)O1)=O)([O])=O)(O[Na])O[Na].[Na]
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    -20°C, stored under nitrogen, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : 125 mg/mL (212.18 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.6974 mL 8.4871 mL 16.9742 mL
    5 mM 0.3395 mL 1.6974 mL 3.3948 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 1.6974 mL 8.4871 mL 16.9742 mL 42.4355 mL
    5 mM 0.3395 mL 1.6974 mL 3.3948 mL 8.4871 mL
    10 mM 0.1697 mL 0.8487 mL 1.6974 mL 4.2435 mL
    15 mM 0.1132 mL 0.5658 mL 1.1316 mL 2.8290 mL
    20 mM 0.0849 mL 0.4244 mL 0.8487 mL 2.1218 mL
    25 mM 0.0679 mL 0.3395 mL 0.6790 mL 1.6974 mL
    30 mM 0.0566 mL 0.2829 mL 0.5658 mL 1.4145 mL
    40 mM 0.0424 mL 0.2122 mL 0.4244 mL 1.0609 mL
    50 mM 0.0339 mL 0.1697 mL 0.3395 mL 0.8487 mL
    60 mM 0.0283 mL 0.1415 mL 0.2829 mL 0.7073 mL
    80 mM 0.0212 mL 0.1061 mL 0.2122 mL 0.5304 mL
    100 mM 0.0170 mL 0.0849 mL 0.1697 mL 0.4244 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Guanosine 5'-triphosphate trisodium Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Guanosine 5'-triphosphate trisodium36051-31-75'-GTP trisodiumExosomesEndogenous MetaboliteDNA/RNA SynthesisHuman myogenic precursor cells (MPCs)skeletal muscle regenerationInhibitorinhibitorinhibit

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