Guanosine 5'-triphosphate trisodium
Based on 6 publication(s) in Google Scholar
Guanosine 5'-triphosphate (5'-GTP) trisodium salt is a G protein (G proteins) signaling activator and a high-energy precursor in the biosynthesis of nucleotide units in DNA and RNA. Guanosine 5'-triphosphate trisodium salt can promote myogenic cell differentiation by upregulating miRNA (miR133a, miR133b) and myogenic regulatory factor expression, and by inducing human myogenic precursor cells to release exosomes containing guanosine molecules. Guanosine-5'-triphosphate trisodium salt holds promise for research in biosynthesis and skeletal muscle regeneration.
For research use only. We do not sell to patients.
- Purity: 95.0%
- CAS No.: 36051-31-7
- Formula: C10H13N5Na3O14P3
- Molecular Weight:589.13
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Storage:
-20°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Guanosine 5'-triphosphate trisodium
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Customer Validation & Images
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Bio/Physico-chemical Assay
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Bio/Physico-chemical Assay
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Bio/Physico-chemical Assay
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Bio/Physico-chemical Assay
All Endogenous Metabolite Isoforms
MoreAll DNA/RNA Synthesis Isoforms
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Biological Activity
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Human Endogenous Metabolite |
Guanosine-5'-triphosphate trisodium salt (500 μM, 24 h) significantly upregulates the expression of miR133a, miR133b, and the myogenic regulatory factor Myogenin in differentiated human myogenic precursor cells (MPCs)[1]. Guanosine-5'-triphosphate trisodium salt (500 μM, 24 h) can induce the release of exosomes from human myogenic precursor cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human myogenic precursor cells (MPCs)
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Concentration:500 μM
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Incubation Time:24 h
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Result:Significantly upregulated Myogenin gene expression.
Chemical Information
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CAS No. 36051-31-7
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Appearance Solid
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Molecular Weight 589.13
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Formula C10H13N5Na3O14P3
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Color White to off-white
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SMILES
O=P(OP(OP(O)(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=NC3=C2NC(N)=NC3=O)O1)=O)([O])=O)(O[Na])O[Na].[Na]
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Synonyms
5'-GTP trisodium
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
Publications (6)
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Journal Impact Factor
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Most Recent
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Mol Cell
Cytoplasmic PARP1 links the genome instability to the inhibition of antiviral immunity through PARylating cGAS. [Abstract]2022 Jun 2;82(11):2032-2049.e7. PMID: 35460603 -
Anal Chim Acta
2021 Dec 15:1188:339180. PMID: 34794559 -
J Biol Chem
Allosteric targeting with antiviral nucleotide analogs allows fine-tuning of SAMHD1 dNTPase activity. [Abstract]2026 Jan 28:111214. PMID: 41617034
Guanosine 5'-triphosphate trisodium purchased from MedChemExpress. Usage Cited in: J Biol Chem. 2026 Jan 28:111214. [Abstract]
Guanosine 5'-triphosphate trisodium (GTP) (0-100 μM) induced the highest maximum SAMHD1 dNTPase activity.
Guanosine 5'-triphosphate trisodium purchased from MedChemExpress. Usage Cited in: J Biol Chem. 2026 Jan 28:111214. [Abstract]
Guanosine 5'-triphosphate trisodium (GTP) (5-1200 μM) effectively induced tetramerization of the recombinant SAMHD1 protein in a dose-dependent manner.
Guanosine 5'-triphosphate trisodium purchased from MedChemExpress. Usage Cited in: J Biol Chem. 2026 Jan 28:111214. [Abstract]
High-confidence fits were obtained for the Guanosine 5'-triphosphate trisodium (GTP) (250 μM; 25 min)-activated hydrolysis of dATP.
Guanosine 5'-triphosphate trisodium purchased from MedChemExpress. Usage Cited in: J Biol Chem. 2026 Jan 28:111214. [Abstract]
In the absence of competitors, increasing Guanosine 5'-triphosphate trisodium (GTP) (0-50 μM) preincubation concentrations led to increasing activity. Guanosine 5'-triphosphate trisodium (GTP) added at the reaction start further increased SAMHD1 activity.
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Bioorg Med Chem
Synthesis and biological evaluation of all possible inosine-mixed cyclic dinucleotides that activate different hSTING variants. [Abstract]2021 Jan 1:29:115899. PMID: 33285409 -
STAR Protoc
Protocol to identify the signaling network of nucleotide second messengers in Shigella sonnei. [Abstract]2026 Mar 20;7(1):104353. PMID: 41671092 -
Solvent & Solubility
H2O : 125 mg/mL (212.18 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (279 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.6974 mL | 8.4871 mL | 16.9742 mL | 42.4355 mL |
| 5 mM | 0.3395 mL | 1.6974 mL | 3.3948 mL | 8.4871 mL | |
| 10 mM | 0.1697 mL | 0.8487 mL | 1.6974 mL | 4.2435 mL | |
| 15 mM | 0.1132 mL | 0.5658 mL | 1.1316 mL | 2.8290 mL | |
| 20 mM | 0.0849 mL | 0.4244 mL | 0.8487 mL | 2.1218 mL | |
| 25 mM | 0.0679 mL | 0.3395 mL | 0.6790 mL | 1.6974 mL | |
| 30 mM | 0.0566 mL | 0.2829 mL | 0.5658 mL | 1.4145 mL | |
| 40 mM | 0.0424 mL | 0.2122 mL | 0.4244 mL | 1.0609 mL | |
| 50 mM | 0.0339 mL | 0.1697 mL | 0.3395 mL | 0.8487 mL | |
| 60 mM | 0.0283 mL | 0.1415 mL | 0.2829 mL | 0.7073 mL | |
| 80 mM | 0.0212 mL | 0.1061 mL | 0.2122 mL | 0.5304 mL | |
| 100 mM | 0.0170 mL | 0.0849 mL | 0.1697 mL | 0.4244 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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