2. Cytoskeleton Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. Exosomes Endogenous Metabolite DNA/RNA Synthesis
  4. Guanosine 5'-triphosphate trisodium salt hydrate

Guanosine 5'-triphosphate trisodium salt hydrate  (Synonyms: 5'-GTP trisodium salt hydrate)

Cat. No.: HY-12695B Purity: 95.0%
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Guanosine 5'-triphosphate (5'-GTP) trisodium salt hydrate is a G protein (G proteins) signaling activator and a high-energy precursor in the biosynthesis of nucleotide units in DNA and RNA. Guanosine 5'-triphosphate trisodium salt hydrate can promote myogenic cell differentiation by upregulating miRNA (miR133a, miR133b) and myogenic regulatory factor expression, and by inducing human myogenic precursor cells to release exosomes containing guanosine molecules. Guanosine-5'-triphosphate disodium salt hydrate holds promise for research in biosynthesis and skeletal muscle regeneration.

For research use only. We do not sell to patients.

CAS No. : 207300-85-4

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Based on 8 publication(s) in Google Scholar

Other Forms of Guanosine 5'-triphosphate trisodium salt hydrate:

Guanosine 5'-triphosphate trisodium salt hydrate Related Antibodies

Top Publications Citing Use of Products

    Guanosine 5'-triphosphate trisodium salt hydrate purchased from MedChemExpress. Usage Cited in: J Biol Chem. 2026 Jan 28:111214.

    Guanosine 5'-triphosphate trisodium (GTP) (0-100 μM) induced the highest maximum SAMHD1 dNTPase activity.

    Guanosine 5'-triphosphate trisodium salt hydrate purchased from MedChemExpress. Usage Cited in: J Biol Chem. 2026 Jan 28:111214.

    Guanosine 5'-triphosphate trisodium (GTP) (5-1200 μM) effectively induced tetramerization of the recombinant SAMHD1 protein in a dose-dependent manner.

    Guanosine 5'-triphosphate trisodium salt hydrate purchased from MedChemExpress. Usage Cited in: J Biol Chem. 2026 Jan 28:111214.

    High-confidence fits were obtained for the Guanosine 5'-triphosphate trisodium (GTP) (250 μM; 25 min)-activated hydrolysis of dATP.

    Guanosine 5'-triphosphate trisodium salt hydrate purchased from MedChemExpress. Usage Cited in: J Biol Chem. 2026 Jan 28:111214.

    In the absence of competitors, increasing Guanosine 5'-triphosphate trisodium (GTP) (0-50 μM) preincubation concentrations led to increasing activity. Guanosine 5'-triphosphate trisodium (GTP) added at the reaction start further increased SAMHD1 activity.

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    Human Endogenous Metabolite Microbial Metabolite

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    Description

    Guanosine 5'-triphosphate (5'-GTP) trisodium salt hydrate is a G protein (G proteins) signaling activator and a high-energy precursor in the biosynthesis of nucleotide units in DNA and RNA. Guanosine 5'-triphosphate trisodium salt hydrate can promote myogenic cell differentiation by upregulating miRNA (miR133a, miR133b) and myogenic regulatory factor expression, and by inducing human myogenic precursor cells to release exosomes containing guanosine molecules. Guanosine-5'-triphosphate disodium salt hydrate holds promise for research in biosynthesis and skeletal muscle regeneration[1].

    IC50 & Target

    Human Endogenous Metabolite

     

    In Vitro

    Guanosine-5'-triphosphate disodium salt (500 μM, 24 h) hydrate significantly upregulates the expression of miR133a, miR133b, and the myogenic regulatory factor Myogenin in differentiated human myogenic precursor cells (MPCs)[1].
    Guanosine-5'-triphosphate disodium salt (500 μM, 24 h) hydrate can induce the release of exosomes from human myogenic precursor cells[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Guanosine 5'-triphosphate trisodium salt hydrate Related Antibodies

    RT-PCR[1]

    Cell Line: Human myogenic precursor cells (MPCs)
    Concentration: 500 μM
    Incubation Time: 500 μM
    Result: Significantly upregulated Myogenin gene expression.
    Formula

    C10H13N5Na3O14P3·xH2O
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C1C(N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](COP(OP(OP(O)(O[Na])=O)(O[Na])=O)(O[Na])=O)O3)=C2NC(N)=N1.[xH2O]
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    -20°C, stored under nitrogen, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : ≥ 150 mg/mL

    *"≥" means soluble, but saturation unknown.

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    Guanosine 5'-triphosphate trisodium salt hydrate Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Guanosine 5'-triphosphate trisodium salt207300-85-45'-GTP trisodium saltExosomesEndogenous MetaboliteDNA/RNA SynthesisInhibitorinhibitorinhibit

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