36051-31-7
Chemical Structure
Guanosine triphosphate trisodium
Synonym(s): GTP trisodium
- CAS No.: 36051-31-7
- Formula:C10H13N5Na3O14P3
- Molecular Weight:589.13
InChIKey: UJYPVFHHCZZEGP-CYCLDIHTSA-L
SMILES: O=C1C(N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](COP(OP(OP(O[Na])(O[Na])=O)(O[Na])=O)(O)=O)O3)=C2NC(N)=N1
Biological Activity: Guanosine triphosphate (GTP) trisodium is a critical nucleotide and regulator of cellular metabolism. Guanosine triphosphate trisodium promotes ribosomal DNA localization, pre-rRNA transcription and ribosome biogenesis by binding to RNA polymerase I and GPN proteins (GPN1/3). Guanosine triphosphate trisodium links MYC-dependent ribosome biogenesis to nucleotide sufficiency, acts as a metabolic gatekeeper supporting protein synthesis, DNA/RNA synthesis and cellular signal transduction, while also participating in the physiological activities of pancreatic β-cells and serving as an oxidative substrate for reactive oxygen species. In small cell lung cancer with high MYC expression, Guanosine triphosphate trisodium accumulates through the IMPDH-driven synthetic pathway, thereby affecting apoptosis and mitotic processes. Guanosine triphosphate trisodium is used in the research of small cell lung cancer, hepatoblastoma and cellular metabolism[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Guanosine triphosphate trisodium | 95.0% | Guanosine triphosphate (GTP) trisodium is a critical nucleotide and regulator of cellular metabolism. Guanosine triphosphate trisodium promotes ribosomal DNA localization, pre-rRNA transcription and ribosome biogenesis by binding to RNA polymerase I and GPN proteins (GPN1/3). Guanosine triphosphate trisodium links MYC-dependent ribosome biogenesis to nucleotide sufficiency, acts as a metabolic gatekeeper supporting protein synthesis, DNA/RNA synthesis and cellular signal transduction, while also participating in the physiological activities of pancreatic β-cells and serving as an oxidative substrate for reactive oxygen species. In small cell lung cancer with high MYC expression, Guanosine triphosphate trisodium accumulates through the IMPDH-driven synthetic pathway, thereby affecting apoptosis and mitotic processes. Guanosine triphosphate trisodium is used in the research of small cell lung cancer, hepatoblastoma and cellular metabolism. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
GTP trisodium salt, 100 mM Solution, PCR Grade | GTP trisodium salt, 100 mM Solution, PCR Grade (Guanosine triphosphate trisodium salt, 100 mM Solution, PCR Grade) is a solution prepared from GTP at a concentration of 100 mM, free of DNase, RNase and phosphatase contamination, and suitable for molecular biology research. The product specifications provided below indicate the total amount only; they do not represent the actual content of GTP trisodium salt. |
|||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
-
Similarity Score 0.81
HY-137677GTP-γ-S -
Similarity Score 0.80
HY-1556005′-Guanylyl methylenediphosphonate sodium -
Similarity Score 0.79
HY-146708S((2R,3S,4R,5R)-5-(2-Amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate-15N4 sodium -
Similarity Score 0.79
HY-W010737Guanosine triphosphate disodium -
Similarity Score 0.77
HY-1720023'-O-Methylguanosine-5'-O-triphosphate sodium -
Similarity Score 0.75
HY-W013706RInosine-5'-triphosphate trisodium salt (Standard) -
Similarity Score 0.75
HY-113225Guanosine triphosphate -
Similarity Score 0.74
HY-W749893dGDP sodium -
Similarity Score 0.74
HY-113066CGuanosine 5'-diphosphate sodium, 96% (HPLC) -
Explore the MedChemAI to find more analogs
References
- [1]. Huang F, et al. Guanosine triphosphate links MYC-dependent metabolic and ribosome programs in small-cell lung cancer. J Clin Invest. 2021;131(1):e139929. [Content Brief]
- [2]. Li G, et al. Prolonged depletion of guanosine triphosphate induces death of insulin-secreting cells by apoptosis. Endocrinology. 1998;139(9):3752-3762. [Content Brief]
- [3]. Bolin C, et al. Assessing biomarkers of oxidative stress: analysis of guanosine and oxidized guanosine nucleotide triphosphates by high performance liquid chromatography with electrochemical detection. J Chromatogr B Analyt Technol Biomed Life Sci. 2007;856(1-2):121-130. [Content Brief]
