1. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  2. HSP
  3. AMP-PCP disodium

AMP-PCP disodium 

Cat. No.: HY-106723A Purity: >99.0%
Handling Instructions

AMP-PCP disodium is an ATP analogue and can bind to Hsp90 N-terminal domain with a Kd value of 3.8 μM. AMP-PCP disodium binding favors the formation of the active homodimer of Hsp90.

For research use only. We do not sell to patients.

AMP-PCP disodium Chemical Structure

AMP-PCP disodium Chemical Structure

CAS No. : 7414-56-4

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1 mg USD 60 In-stock
Estimated Time of Arrival: December 31
5 mg USD 180 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

AMP-PCP disodium is an ATP analogue and can bind to Hsp90 N-terminal domain with a Kd value of 3.8 μM. AMP-PCP disodium binding favors the formation of the active homodimer of Hsp90[1].

IC50 & Target[1]

HSP90

3.8 μM (Kd)

In Vitro

AMP-PCP binding favors the formation of the active homodimer of Hsp90 by enhancing the slow-motion featured conformational exchanges of those residues (A117-A141) within the lid segment (A111-G135) and around region. In total, 170 non-proline residues are identified for the triple-labeled Hsp90 bound with AMP-PCP[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

549.17

Formula

C₁₁H₁₆N₅Na₂O₁₂P₃

CAS No.

7414-56-4

SMILES

O[[email protected]]1[[email protected]@H](O[[email protected]](COP(OP(CP(O)(O[Na])=O)(O[Na])=O)(O)=O)[[email protected]]1O)N2C3=C(C(N)=NC=N3)N=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
References

Purity: >99.0%

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Keywords:

AMP-PCP disodiumHSPHeat shock proteinsATPhomodimerHsp90residuesconformationalN-terminalATPaseInhibitorinhibitorinhibit

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AMP-PCP disodium
Cat. No.:
HY-106723A
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