AMP-PCP disodium
Based on 2 publication(s) in Google Scholar
AMP-PCP disodium is an ATP analogue and can bind to Hsp90 N-terminal domain with a Kd value of 3.8 μM. AMP-PCP disodium binding favors the formation of the active homodimer of Hsp90.
For research use only. We do not sell to patients.
- Purity: 99.91%
- CAS No.: 7414-56-4
- Formula: C11H16N5Na2O12P3
- Molecular Weight:549.17
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) AMP-PCP disodium
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Biological Activity
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HSP90 3.8 μM (Kd) |
AMP-PCP binding favors the formation of the active homodimer of Hsp90 by enhancing the slow-motion featured conformational exchanges of those residues (A117-A141) within the lid segment (A111-G135) and around region. In total, 170 non-proline residues are identified for the triple-labeled Hsp90 bound with AMP-PCP[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 7414-56-4
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Appearance Solid
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Molecular Weight 549.17
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Formula C11H16N5Na2O12P3
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Color White to off-white
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SMILES
O[C@H]1[C@@H](O[C@H](COP(OP(CP(O)(O[Na])=O)(O[Na])=O)(O)=O)[C@H]1O)N2C3=C(C(N)=NC=N3)N=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
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Nat Commun
Nanomaterial signatures program biomolecular condensates via triphasic separation for chemoplasticity remodeling. [Abstract]2025 Oct 29;16(1):9554. PMID: 41162367 -
ACS Nano
Emerging of Ultrafine Membraneless Organelles as the Missing Piece of Nanostress: Mechanism of Biogenesis and Implications at Multilevels. [Abstract]2025 Feb 11;19(5):5659-5679. PMID: 39882824
Solvent & Solubility
H2O : 100 mg/mL (182.09 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (91.05 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (273 KB)
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SDS (481 KB)
- English - EN (481 KB)
- Français - FR (481 KB)
- Deutsch - DE (481 KB)
- Norwegian - NO (481 KB)
- Español - ES (481 KB)
- Swedish - SV (481 KB)
- Italian - IT (481 KB)
- Korean - KR (481 KB)
- Portuguese - PT (481 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.8209 mL | 9.1046 mL | 18.2093 mL | 45.5232 mL |
| 5 mM | 0.3642 mL | 1.8209 mL | 3.6419 mL | 9.1046 mL | |
| 10 mM | 0.1821 mL | 0.9105 mL | 1.8209 mL | 4.5523 mL | |
| 15 mM | 0.1214 mL | 0.6070 mL | 1.2140 mL | 3.0349 mL | |
| 20 mM | 0.0910 mL | 0.4552 mL | 0.9105 mL | 2.2762 mL | |
| 25 mM | 0.0728 mL | 0.3642 mL | 0.7284 mL | 1.8209 mL | |
| 30 mM | 0.0607 mL | 0.3035 mL | 0.6070 mL | 1.5174 mL | |
| 40 mM | 0.0455 mL | 0.2276 mL | 0.4552 mL | 1.1381 mL | |
| 50 mM | 0.0364 mL | 0.1821 mL | 0.3642 mL | 0.9105 mL | |
| 60 mM | 0.0303 mL | 0.1517 mL | 0.3035 mL | 0.7587 mL | |
| 80 mM | 0.0228 mL | 0.1138 mL | 0.2276 mL | 0.5690 mL | |
| 100 mM | 0.0182 mL | 0.0910 mL | 0.1821 mL | 0.4552 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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