Adenosine 5'-diphosphate sodium salt
Based on 9 publication(s) in Google Scholar
Adenosine 5'-diphosphate sodium salt is a nucleoside diphosphate and the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate sodium salt induces human platelet aggregation and inhibits stimulated adenylate cyclase through its action on P2T-purinergic receptors.
For research use only. We do not sell to patients.
- Purity: 99.83%
- CAS No.: 20398-34-9
- Formula: C10H15N5O10P2.xNa
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Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications Citing Use of MedChemExpress (MCE) Adenosine 5'-diphosphate sodium salt
More- Nature. 2026 Jan;649(8096):423-431. [Abstract]
- Adv Mater. 2025 Apr;37(17):e2416349. [Abstract]
- Redox Biol. 2024 Aug:74:103225. [Abstract]
- Acta Pharm Sin B. 2025 Oct 24.
- Chem Eng J. 2026 Feb 12.
- Phytomedicine. 2025 Dec:149:157553. [Abstract]
- Int J Biol Macromol. 2025 Jun;311(Pt 3):144068. [Abstract]
- Molecules. 2025 Mar 9;30(6):1224. [Abstract]
- Cell Biomater. 2026 Mar 6.
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Flow Cytometry
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Others
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WB
All Endogenous Metabolite Isoforms
More
Biological Activity
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Human Endogenous Metabolite |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Cerebral cortex neuron | EC50 |
19 μM
Compound: 2
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Neuroprotective activity against Fe2+-induced oxidative damage in rat primary cortical neurons assessed as cell viability after 24 hrs by MTT assay
Neuroprotective activity against Fe2+-induced oxidative damage in rat primary cortical neurons assessed as cell viability after 24 hrs by MTT assay
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[PMID: 26447940] |
| PC-12 | IC50 |
21 μM
Compound: 2
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Antioxidant activity in rat PC12 cells assessed as inhibition of Fe2+-induced reactive oxygen species formation after 1 hr by DCFH-DA dye-based fluorometric analysis
Antioxidant activity in rat PC12 cells assessed as inhibition of Fe2+-induced reactive oxygen species formation after 1 hr by DCFH-DA dye-based fluorometric analysis
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[PMID: 26447940] |
| PC-12 | IC50 |
21 μM
Compound: 2, ADP
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Antioxidant activity in rat PC12 cells assessed as inhibition of Fe2+-induced ROS production after 1 hr by DCFH-DA staining-based fluorometric analysis
Antioxidant activity in rat PC12 cells assessed as inhibition of Fe2+-induced ROS production after 1 hr by DCFH-DA staining-based fluorometric analysis
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[PMID: 23751098] |
Adenosine 5'-diphosphate sodium salt potently induces full maximal aggregation of human platelets, with a pA50 of 5.87[2].
Adenosine 5'-diphosphate sodium salt (5 μM; 30 seconds) inhibits the prostaglandin E1 (PGE1)-stimulated adenylate cyclase activity in human platelets by 71%[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 20398-34-9
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Appearance Solid
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Formula C10H15N5O10P2.xNa
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Color White to off-white
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SMILES
NC1=C(N=CN2[C@@]3([H])[C@@](O)([H])[C@@](O)([H])[C@@](O3)([H])COP(O)(OP(O)(O)=O)=O)C2=NC=N1.[x].[Na]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (9)
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Journal Impact Factor
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Most Recent
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Nature
2026 Jan;649(8096):423-431. PMID: 41193806 -
Adv Mater
2025 Apr;37(17):e2416349. PMID: 40025988 -
Redox Biol
FAM3A plays a key role in protecting against tubular cell pyroptosis and acute kidney injury. [Abstract]2024 Aug:74:103225. PMID: 38875957
Adenosine 5'-diphosphate sodium salt purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Aug:74:103225. [Abstract]
ADP (5 mM; 1 h). Representative Western blots show the protein levels of p-PI3K, PI3K, p-AKT, AKT, p-NRF2, NRF2, GSDMD, and GSDMD-N in different groups.
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Phytomedicine
Liquiritigenin attenuates thrombosis by inhibiting P2Y12R-mediated Src/PLCγ2 signaling and cytoplasmic Ca2+ mobilization in platelets. [Abstract]2025 Dec:149:157553. PMID: 41273866
Adenosine 5'-diphosphate sodium salt purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Dec:149:157553. [Abstract]
Flow cytometry analysis of CD61 and CD62P expression in ADP (20 μM; 10 min) -stimulated platelets after glycyrrhizin treatment.
Adenosine 5'-diphosphate sodium salt purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Dec:149:157553. [Abstract]
Quantitative analysis of the adhesion thickness of platelets on fibrinogen-coated surfaces after ADP (20 μM) activation, with or without glycyrrhizin treatment.
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Int J Biol Macromol
FKBP5 inhibitor suppresses platelet activation and thrombosis by inhibiting IKBKE/PI3K/Rap1 pathway. [Abstract]2025 Jun;311(Pt 3):144068. PMID: 40345291 -
Molecules
Seeking Correlation Among Porin Permeabilities and Minimum Inhibitory Concentrations Through Machine Learning: A Promising Route to the Essential Molecular Descriptors. [Abstract]2025 Mar 9;30(6):1224. PMID: 40142001 -
Solvent & Solubility
H2O : ≥ 25 mg/mL
DMSO : 25 mg/mL (ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Purity & Documentation
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Data Sheet (275 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)