ATP-13C10,15N5 ammonium solution (100mM)
Based on 1 Customer Validation
ATP-13C10,15N5 (Adenosine 5'-triphosphate-ATP-13C10,15N5) ammonium solution (100 mM) is the 13C10,15N5-labeled ATP (HY-B2176). ATP is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation. ATP can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP has anti-bacterial infection effects and can protect mice against bacterial infection in mice.
For research use only. We do not sell to patients.
- Purity : 98.13%
- CAS No.: 2483830-25-5
- Formula: 13C10H28N415N5O13P3
- Molecular Weight:590.20
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Storage:
Solution, -20°C, 2 years
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Description
IC50 & Target
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NLRP3 inflammasome |
IL-1β |
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 2483830-25-5
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Unlabeled CAS 56-65-5
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Appearance Liquid
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Molecular Weight 590.20
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Formula 13C10H28N415N5O13P3
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Color Colorless to light yellow
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SMILES
O=P(O)(O)OP(OP(O[13CH2][13C@H]1O[13C@@H]([15N]2[13C]3=[15N][13CH]=[15N][13C]([15NH2])=[13C]3[15N]=[13CH]2)[13C@H](O)[13C@@H]1O)(O)=O)(O)=O.[4NH3]
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Synonyms
Adenosine 5'-triphosphate-13C10,15N5 ammonium solution (100mM)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Solution, -20°C, 2 years
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Swennen EL, et al. Immunoregulatory effects of adenosine 5'-triphosphate on cytokine release from stimulated whole blood. Eur J Immunol. 2005 Mar;35(3):852-8. [Content Brief]
[2]. M J L Bours, et al. Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther. 2006 Nov;112(2):358-404. [Content Brief]
[3]. Shuo Xu, et al. Doxycycline inhibits NAcht Leucine-rich repeat Protein 3 inflammasome activation and interleukin-1β production induced by Porphyromonas gingivalis-lipopolysaccharide and adenosine triphosphate in human gingival fibroblasts. Arch Oral Biol. 2019 Nov;107:104514. [Content Brief]
[4]. Yang Xiang, et al. Adenosine-5'-Triphosphate (ATP) Protects Mice against Bacterial Infection by Activation of the NLRP3 Inflammasome. PLoS One. 2013; 8(5): e63759. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ATP-13C10,15N5 ammonium solution (100mM) Related Classifications
HY-150709S Related Classifications
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Keywords
- ATP-13C10,15N5 ammonium solution (100mM)
- 2483830-25-5
- Adenosine 5'-triphosphate-13C10,15N5 ammonium solution (100mM)
- Isotope-Labeled Compounds
- Endogenous Metabolite
- NOD-like Receptor (NLR)
- Interleukin Related
- Bacterial
- energy
- storage
- metabolism
- immunity
- inflammation
- NLRP3
- inflammasome
- cytokine
- Inhibitor
- inhibitor
- inhibit