Sp-ATPαS
Sp-ATPαS is a regulator of ATP-binding proteins. Sp-ATPαS is a competitive antagonist of the human P2Y1 receptor, which can inhibit the calcium signal induced by ADP. Sp-ATPαS is metabolically more stable than ATP. Sp-ATPαS can be used to study the binding patterns of metals and nucleotides in enzymatic reactions.
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- CAS No.: 58976-48-0
- Formula: C10H16N5O12P3S
- Molecular Weight:523.25
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
Chemical Information
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CAS No. 58976-48-0
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Molecular Weight 523.25
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Formula C10H16N5O12P3S
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SMILES
O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=CN=C3N)O[C@@H]1CO[P@@](OP(OP(O)(O)=O)(O)=O)(S)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Ca2+ Staining Technique
Ca2+ staining is an experimental technique that utilizes specific fluorescent probes (such as Fluo-4 AM, Fura-2, etc.) to qualitatively or quantitatively detect dynamic changes in intracellular Ca2+ concentrations; this is achieved by monitoring the changes in fluorescent signals generated when these probes bind to free intracellular calcium ions. The underlying principle relies primarily on the presence of chelating groups within the probe's molecular structure that possess high affinity for calcium ions.
Purity & Documentation
References
[1]. Connolly BA, Eckstein F. S-Methylated nucleoside phosphorothioates as probes of enzyme metal X nucleotide binding sites. Biochemistry. 1982 Nov 23;21(24):6158-67. [Content Brief]
[2]. Léon C, et al. The P2Y1 receptor is an ADP receptor antagonized by ATP and expressed in platelets and megakaryoblastic cells. FEBS Lett. 1997 Feb 10;403(1):26-30. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sp-ATPαS Related Classifications
HY-137626 Related Classifications
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