525-66-6
Chemical Structure
Propranolol
- CAS No.: 525-66-6
- Formula:C16H21NO2
- Molecular Weight:259.34
IUPAC Name: 1-(isopropylamino)-3-(naphthalen-1-yloxy)propan-2-ol
InChIKey: AQHHHDLHHXJYJD-UHFFFAOYSA-N
SMILES: OC(CNC(C)C)COC1=C2C=CC=CC2=CC=C1
Biological Activity: Propranolol is a nonselective and BBB-permeable β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively[1]. Propranolol inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM[2]. Propranolol is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy[3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Propranolol | 99.91% | Propranolol is a nonselective and BBB-permeable β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively. Propranolol inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM. Propranolol is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy. | ||||||||||||||||||||
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Propranolol-d7 | 98.55% | Propranolol-d7 is the deuterium labeled Propranolol. Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively. Propranolol inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM. Propranolol is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy. | ||||||||||||||||||||
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Similarity Score 0.98
HY-B0573CS(R)-Propranolol-d7 -
Similarity Score 0.98
HY-B0573SPropranolol-d7 hydrochloride -
Similarity Score 0.98
HY-A0295(R)-Propranolol hydrochloride -
Similarity Score 0.98
HY-B0573Propranolol hydrochloride -
Similarity Score 0.98
HY-B0573A(S)-(-)-Propranolol hydrochloride -
Similarity Score 0.88
HY-100634SA4-Hydroxypropranolol-d7 -
Similarity Score 0.87
HY-100634S4-Hydroxypropranolol-d7 hydrochloride -
Similarity Score 0.86
HY-W789980S4-Methoxy propranolol-d7 -
Similarity Score 0.85
HY-1292545-Hydroxy propranolol -
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References
- [1]. Galandrin S, et al. Distinct signaling profiles of beta1 and beta2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy. Mol Pharmacol. 2006 Nov;70(5):1575-84. Epub 2006 Aug 1 [Content Brief]
- [2]. Briley M, et al. Evidence against beta-adrenoceptor blocking activity of diltiazem, a drug with calcium antagonist properties. Br J Pharmacol. 1980 Aug;69(4):669-73. [Content Brief]
- [3]. Al-Majed AA, et al. Propranolol. Profiles Drug Subst Excip Relat Methodol. 2017;42:287-338. [Content Brief]
