1. GPCR/G Protein Neuronal Signaling Anti-infection
  2. Adrenergic Receptor Bacterial
  3. Propranolol

Propranolol 

Cat. No.: HY-B0573B Purity: 99.83%
COA Handling Instructions

Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively. Propranolol inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM. Propranolol is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy.

For research use only. We do not sell to patients.

Propranolol Chemical Structure

Propranolol Chemical Structure

CAS No. : 525-66-6

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10 mM * 1 mL in DMSO
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Based on 18 publication(s) in Google Scholar

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Description

Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively[1]. Propranolol inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM[2]. Propranolol is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy[3].

IC50 & Target

β adrenergic receptor

 

In Vitro

Propranolol (10-7 M-10-3 M; 24 and 48 hours) increases the total ERK1/2 levels in a dose-dependent manner, and ERK1/2 activation is observed specifically at 10-5 M in HemSCs[4].
? Propranolol (10-9 M-10-3 M; 24 and 48 hours) significant decreases cell proliferation at 10-4 M propranolol after 24 hours and 10-9 M propranolol after 48 hours in HemSCs[4].
? Propranolol (50 μM-200 μM;24 hours) increases Annexin V positivity and caspase-3 activation, rapidly induces HemSC apoptosis[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[4]

Cell Line: HemSC cells
Concentration: 10-7 M-10-3 M
Incubation Time: 24 and 48 hours
Result: Increased the total ERK1/2 levels in a dose-dependent manner.

Cell Proliferation Assay[4]

Cell Line: HemSC cells
Concentration: 10-9 M-10-3 M
Incubation Time: 24 and 48 hours
Result: Suppressed HemSC proliferation.

Apoptosis Analysis[4]

Cell Line: HemSC cells
Concentration: 50 μM, 100 μM, or 200 μM
Incubation Time: 24 hours
Result: Induced HemSC cell death occurred via an apoptotic pathway.
In Vivo

Propranolol (orally administration; 40 mg/kg; daily) significantly reduces the vessel diameter relative to the vehicle-treated implants, and increases the number of cells that expressed phosphorylated ERK1/2 within the IH Matrigel implant[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: A xenograft mouse model of IH (infantile hemangiomas ) with HemSC cells[4]
Dosage: 40 mg/kg
Administration: Orally administration; 40 mg/kg; daily
Result: Improved vessel development in the IH mouse model that correlated with MAPK pathway activation.
Clinical Trial
Molecular Weight

259.34

Formula

C16H21NO2

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(COC1=C2C=CC=CC2=CC=C1)CNC(C)C

Structure Classification
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 1 year
-20°C 6 months
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (385.59 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8559 mL 19.2797 mL 38.5594 mL
5 mM 0.7712 mL 3.8559 mL 7.7119 mL
10 mM 0.3856 mL 1.9280 mL 3.8559 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (9.64 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (9.64 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (9.64 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.87%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Propranolol
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HY-B0573B
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