1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. Propranolol

Propranolol 

Cat. No.: HY-B0573B
Handling Instructions

Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively. Propranolol inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM. Propranolol is used to control hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy.

For research use only. We do not sell to patients.

Propranolol Chemical Structure

Propranolol Chemical Structure

CAS No. : 525-66-6

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Description

Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively[1]. Propranolol inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM[2]. Propranolol is used to control hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy[3].

In Vitro

Propranolol (10-7 M-10-3 M; 24 and 48 hours) increases the total ERK1/2 levels in a dose-dependent manner, and ERK1/2 activation is observed specifically at 10-5 M in HemSCs[4].
Propranolol (10-9 M-10-3 M; 24 and 48 hours) significant decreases cell proliferation at 10-4 M propranolol after 24 hours and 10-9 M propranolol after 48 hours in HemSCs[4].
Propranolol (50 μM-200 μM;24 hours) increases Annexin V positivity and caspase-3 activation, rapidly induces HemSC apoptosis[4].

Western Blot Analysis[4]

Cell Line: HemSC cells
Concentration: 10-7 M-10-3 M
Incubation Time: 24 and 48 hours
Result: Increased the total ERK1/2 levels in a dose-dependent manner.

Cell Proliferation Assay[4]

Cell Line: HemSC cells
Concentration: 10-9 M-10-3 M
Incubation Time: 24 and 48 hours
Result: Suppressed HemSC proliferation.

Apoptosis Analysis[4]

Cell Line: HemSC cells
Concentration: 50 μM, 100 μM, or 200 μM
Incubation Time: 24 hours
Result: Induced HemSC cell death occurred via an apoptotic pathway.
In Vivo

Propranolol (orally administration; 40 mg/kg; daily) significantly reduces the vessel diameter relative to the vehicle-treated implants, and increases the number of cells that expressed phosphorylated ERK1/2 within the IH Matrigel implant[4].

Animal Model: A xenograft mouse model of IH (infantile hemangiomas ) with HemSC cells[4]
Dosage: 40 mg/kg
Administration: Orally administration; 40 mg/kg; daily
Result: Improved vessel development in the IH mouse model that correlated with MAPK pathway activation.
Molecular Weight

259.34

Formula

C₁₆H₂₁NO₂

CAS No.

525-66-6

SMILES

OC(COC1=C2C=CC=CC2=CC=C1)CNC(C)C

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Propranolol
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