2. GPCR/G Protein Neuronal Signaling Anti-infection
  3. Adrenergic Receptor Bacterial
  4. Propranolol hydrochloride

Propranolol hydrochloride is a nonselective and BBB-permeableβ-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively. Propranolol hydrochloride inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM. Propranolol hydrochloride is used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy.

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CAS No. : 318-98-9

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10 mM * 1 mL in DMSO
ready for reconstitution
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Customer Review

Based on 44 publication(s) in Google Scholar

Other Forms of Propranolol hydrochloride:

Propranolol hydrochloride Related Antibodies

Top Publications Citing Use of Products

44 Publications Citing Use of MCE Propranolol hydrochloride

In Vivo Efficacy Study
IF
WB

    Propranolol hydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Oct 6:e04817.  [Abstract]

    Propranolol (2 mg/kg; ip; 21 days). Quantitative of sperm density in the cauda epididymis.

    Propranolol hydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Oct 6:e04817.  [Abstract]

    Propranolol (2 mg/kg; ip; 21 days). Western blot of SOX9 expression across four experimental groups.

    Propranolol hydrochloride purchased from MedChemExpress. Usage Cited in: Bone Res. 2024 Mar 21;12(1):18.  [Abstract]

    Representative μCT images of femurs from OVX, OVX + Fx (fracture), and OVX + Fx mice treated with Pro (Propranolol; 0.5 g/L; 4 weeks), PTH or PTH + Pro.

    Propranolol hydrochloride purchased from MedChemExpress. Usage Cited in: Bone Res. 2024 Mar 21;12(1):18.  [Abstract]

    Representative images of co-localization of Bmal1 (green) and OCN (red) immunofluorescent staining in distal femurs from OVX, OVX + Fx, and OVX + Fx mice treated with Pro (Propranolol; 0.5 g/L; 4 weeks), PTH or PTH + Pro.

    Propranolol hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 May 2;14(1):2523.  [Abstract]

    Mice received PBS or Propranolol (5 mg/kg) 30 mins before the injection of PBS or 1 mg/kg BK for 15 mins in the absence of food and water at 25 °C. Rectal temperature at different time point.

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    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Propranolol hydrochloride is a nonselective and BBB-permeableβ-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively. Propranolol hydrochloride inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM. Propranolol hydrochloride is used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy[1][2][3][4][5].

    IC50 & Target

    β adrenergic receptor

     

    Cellular Effect
    Cell Line Type Value Description References
    Platelet IC50
    > 939.8 μM
    Compound: Propranolol hydrochloride
    Antimigraine activity in bovine citreated platelet assessed as inhibition of [14C]serotonin release after 6 mins by scintillation counting
    Antimigraine activity in bovine citreated platelet assessed as inhibition of [14C]serotonin release after 6 mins by scintillation counting
    		[PMID: 1431933]
    In Vitro

    Propranolol hydrochloride (10-7 M-10-3 M; 24 and 48 hours) increases the total ERK1/2 levels in a dose-dependent manner, and ERK1/2 activation is observed specifically at 10-5 M in HemSCs[4].
    Propranolol hydrochloride (10-9 M-10-3 M; 24 and 48 hours) significant decreases cell proliferation at 10-4 M propranolol after 24 hours and 10-9 M propranolol after 48 hours in HemSCs[4].
    Propranolol hydrochloride (50 μM-200 μM; 24 hours) increases Annexin V positivity and caspase-3 activation, rapidly induces HemSC apoptosis[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Propranolol hydrochloride Related Antibodies

    Western Blot Analysis[4]

    Cell Line: HemSC cells
    Concentration: 10-7 M-10-3 M
    Incubation Time: 24 and 48 hours
    Result: Increased the total ERK1/2 levels in a dose-dependent manner.

    Cell Viability Assay[4]

    Cell Line: HemSC cells
    Concentration: 10-9 M-10-3 M
    Incubation Time: 24 and 48 hours
    Result: Suppressed HemSC Proliferation.

    Apoptosis Analysis[4]

    Cell Line: HemSC cells
    Concentration: 50 μM, 100 μM, or 200 μM
    Incubation Time: 24 hours
    Result: Induced HemSC cell death occurred via an apoptotic pathway.
    In Vivo

    Propranolol hydrochloride (orally administration; 40 mg/kg; daily) significantly reduces the vessel diameter relative to the vehicle-treated implants, and increases the number of cells that expressed phosphorylated ERK1/2 within the IH Matrigel implant[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: A xenograft mouse model of IH (infantile hemangiomas) with HemSC cells[4]
    Dosage: 40 mg/kg
    Administration: Orally administration; 40 mg/kg; daily
    Result: Improved vessel development in the IH mouse model that correlated with MAPK pathway activation.
    Clinical Trial
    Molecular Weight

    295.80

    Formula

    C16H22ClNO2
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    OC(CNC(C)C)COC1=CC=CC2=CC=CC=C12.Cl
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 150 mg/mL (507.10 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : 33.33 mg/mL (112.68 mM; Need ultrasonic)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.3807 mL 16.9033 mL 33.8066 mL
    5 mM 0.6761 mL 3.3807 mL 6.7613 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    Volume (start)

    V1

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    Concentration (final)

    C2

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    Volume (final)

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    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 25 mg/mL (84.52 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.95%

    SDS (396 KB)

    COA (249 KB) RP-HPLC (240 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 3.3807 mL 16.9033 mL 33.8066 mL 84.5166 mL
    5 mM 0.6761 mL 3.3807 mL 6.7613 mL 16.9033 mL
    10 mM 0.3381 mL 1.6903 mL 3.3807 mL 8.4517 mL
    15 mM 0.2254 mL 1.1269 mL 2.2538 mL 5.6344 mL
    20 mM 0.1690 mL 0.8452 mL 1.6903 mL 4.2258 mL
    25 mM 0.1352 mL 0.6761 mL 1.3523 mL 3.3807 mL
    30 mM 0.1127 mL 0.5634 mL 1.1269 mL 2.8172 mL
    40 mM 0.0845 mL 0.4226 mL 0.8452 mL 2.1129 mL
    50 mM 0.0676 mL 0.3381 mL 0.6761 mL 1.6903 mL
    60 mM 0.0563 mL 0.2817 mL 0.5634 mL 1.4086 mL
    80 mM 0.0423 mL 0.2113 mL 0.4226 mL 1.0565 mL
    100 mM 0.0338 mL 0.1690 mL 0.3381 mL 0.8452 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Propranolol hydrochloride Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Propranolol318-98-9Adrenergic ReceptorBacterialBeta ReceptorInhibitorinhibitorinhibit

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