Propranolol-d7 hydrochloride
Based on 1 Customer Validation
Propranolol-d7 (hydrochloride) is a deuterium labeled Propranolol hydrochloride. Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively. Propranolol hydrochloride inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM. Propranolol hydrochloride is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy.
For research use only. We do not sell to patients.
- Purity: 98.47%
- CAS No.: 1613439-56-7
- Formula: C16H15D7ClNO2
- Molecular Weight:302.85
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Adrenergic Receptor Isoforms
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Biological Activity
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β adrenergic receptor |
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1613439-56-7
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Unlabeled Cas 318-98-9
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Appearance Solid
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Molecular Weight 302.85
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Formula C16H15D7ClNO2
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Color White to off-white
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SMILES
OC(COC1=C2C=CC=CC2=CC=C1)CNC(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H].[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (330.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Handling Instructions (2659 KB)
References
[1]. Galandrin S, et al. Distinct signaling profiles of beta1 and beta2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy. Mol Pharmacol. 2006 Nov;70(5):1575-84. [Content Brief]
[2]. Briley M, et al. Evidence against beta-adrenoceptor blocking activity of diltiazem, a drug with calcium antagonist properties. Br J Pharmacol. 1980 Aug;69(4):669-73. [Content Brief]
[3]. Al-Majed AA, et al. Propranolol. Profiles Drug Subst Excip Relat Methodol. 2017;42:287-338. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3020 mL | 16.5098 mL | 33.0196 mL | 82.5491 mL |
| 5 mM | 0.6604 mL | 3.3020 mL | 6.6039 mL | 16.5098 mL | |
| 10 mM | 0.3302 mL | 1.6510 mL | 3.3020 mL | 8.2549 mL | |
| 15 mM | 0.2201 mL | 1.1007 mL | 2.2013 mL | 5.5033 mL | |
| 20 mM | 0.1651 mL | 0.8255 mL | 1.6510 mL | 4.1275 mL | |
| 25 mM | 0.1321 mL | 0.6604 mL | 1.3208 mL | 3.3020 mL | |
| 30 mM | 0.1101 mL | 0.5503 mL | 1.1007 mL | 2.7516 mL | |
| 40 mM | 0.0825 mL | 0.4127 mL | 0.8255 mL | 2.0637 mL | |
| 50 mM | 0.0660 mL | 0.3302 mL | 0.6604 mL | 1.6510 mL | |
| 60 mM | 0.0550 mL | 0.2752 mL | 0.5503 mL | 1.3758 mL | |
| 80 mM | 0.0413 mL | 0.2064 mL | 0.4127 mL | 1.0319 mL | |
| 100 mM | 0.0330 mL | 0.1651 mL | 0.3302 mL | 0.8255 mL |
Propranolol-d7 hydrochloride Related Classifications
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