2. Propranolol-d7 hydrochloride

Propranolol-d7 (hydrochloride) is a deuterium labeled Propranolol hydrochloride. Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively[1]. Propranolol hydrochloride inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM[2]. Propranolol hydrochloride is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy[3].

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Propranolol-d7 hydrochloride Chemical Structure

Propranolol-d7 hydrochloride Chemical Structure

CAS No. : 1613439-56-7

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Other Forms of Propranolol-d7 hydrochloride:

Propranolol-d7 hydrochloride Related Antibodies

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Description

Propranolol-d7 (hydrochloride) is a deuterium labeled Propranolol hydrochloride. Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively[1]. Propranolol hydrochloride inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM[2]. Propranolol hydrochloride is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy[3].

IC50 & Target

IC50: 12 nM (βAR)[1]
Molecular Weight

302.85

Formula

C16H15D7ClNO2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(COC1=C2C=CC=CC2=CC=C1)CNC(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H].[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (330.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3020 mL 16.5098 mL 33.0196 mL
5 mM 0.6604 mL 3.3020 mL 6.6039 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3020 mL 16.5098 mL 33.0196 mL 82.5491 mL
5 mM 0.6604 mL 3.3020 mL 6.6039 mL 16.5098 mL
10 mM 0.3302 mL 1.6510 mL 3.3020 mL 8.2549 mL
15 mM 0.2201 mL 1.1007 mL 2.2013 mL 5.5033 mL
20 mM 0.1651 mL 0.8255 mL 1.6510 mL 4.1275 mL
25 mM 0.1321 mL 0.6604 mL 1.3208 mL 3.3020 mL
30 mM 0.1101 mL 0.5503 mL 1.1007 mL 2.7516 mL
40 mM 0.0825 mL 0.4127 mL 0.8255 mL 2.0637 mL
50 mM 0.0660 mL 0.3302 mL 0.6604 mL 1.6510 mL
60 mM 0.0550 mL 0.2752 mL 0.5503 mL 1.3758 mL
80 mM 0.0413 mL 0.2064 mL 0.4127 mL 1.0319 mL
100 mM 0.0330 mL 0.1651 mL 0.3302 mL 0.8255 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Propranolol-d71613439-56-7Inhibitorinhibitorinhibit

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