Aporphine Alkaloids

Nuciferine is an antagonist at 5-HT_2A (IC₅₀=478 nM), 5-HT_2C (IC₅₀=131 nM), and 5-HT_2B (IC₅₀=1 μM), an inverse agonist at 5-HT₇ (IC₅₀=150 nM), a partial agonist at D₂ (EC₅₀=64 nM), D₅ (EC₅₀=2.6 μM) and 5-HT₆ (EC₅₀=700 nM), an agonist at 5-HT_1A (EC₅₀=3.2 μM) and D₄ (EC₅₀=2 μM) receptor.

Roemerine is an alkaloid that has been identified from the leaves of Fibraurea recisa Pierre. Roemerine exhibits antibacterial, anticancer, and antidepressant activities, can reverse the multidrug resistance phenotype in cultured cells, and exerts antibacterial effects by regulating the cAMP signaling pathway. Additionally, Roemerine influences neuronal activity by increasing BDNF protein expression and modulating the serotonergic and glutamatergic systems. Roemerine holds promise for research in the fields of cancer, infections, and neurological diseases.

(-)-Dicentrine is an aporphine alkaloid that can be isolated from the stem bark of Talauma arcabucoana. (-)-Dicentrine shows moderate growth inhibition against Staphylococcus aureus and Candida albicans.

(R)-1,2-Dihydroxyaporphine (Compound M1) is a metabolite of Nuciferine (HY-N0049) and is easily excreted through urine and feces.

N-Acetylnornuciferine is an aporphine alkaloid, whose family members possess potential antibacterial, antiviral, antioxidant, or anticancer activities. N-Acetylnornuciferine can be extracted from the dried roots of Liriodendron tulipifera (American tulip tree, a plant of the Magnoliaceae family) using ethanol.

Laurotetanine ((+)-Laurotetanine) is an potent and orally active isoquinoline alkaloid and could be extracted from the roots of Litsea cubeba (Lour.) Pers. Laurotetanine exerts an anti-asthmatic effect by inhibition of IgE, histamine, and inflammatory reactions via down-regulating MUC5AC and NF-κB signaling pathways.

Homostephanoline is a corydane-type alkaloid that can be isolated from species of the Stephania subgenus.

(+)-N-Methylhernovine is an aporphine alkaloid that can be isolated from Hernandia nymphaeifolia. (+)-N-Methylhernovine exhibits slight cytotoxicity in cancer cells.