548-08-3
Chemical Structure
Roemerine
Synonym(s): (-)-Roemerine
- CAS No.: 548-08-3
- Formula:C18H17NO2
- Molecular Weight:279.33
IUPAC Name: (R)-7-methyl-6,7,7a,8-tetrahydro-5H-[1,3]dioxolo[4',5':4,5]benzo[1,2,3-de]benzo[g]quinoline
InChIKey: JCTYWRARKVGOBK-CQSZACIVSA-N
SMILES: CN1CCC(C2=C3C4=CC=CC=C4C[C@@]12[H])=CC5=C3OCO5
Biological Activity: Roemerine is an alkaloid that has been identified from the leaves of Fibraurea recisa Pierre. Roemerine exhibits antibacterial, anticancer, and antidepressant activities, can reverse the multidrug resistance phenotype in cultured cells, and exerts antibacterial effects by regulating the cAMP signaling pathway. Additionally, Roemerine influences neuronal activity by increasing BDNF protein expression and modulating the serotonergic and glutamatergic systems. Roemerine holds promise for research in the fields of cancer, infections, and neurological diseases[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Roemerine | 99.89% | Roemerine is an alkaloid that has been identified from the leaves of Fibraurea recisa Pierre. Roemerine exhibits antibacterial, anticancer, and antidepressant activities, can reverse the multidrug resistance phenotype in cultured cells, and exerts antibacterial effects by regulating the cAMP signaling pathway. Additionally, Roemerine influences neuronal activity by increasing BDNF protein expression and modulating the serotonergic and glutamatergic systems. Roemerine holds promise for research in the fields of cancer, infections, and neurological diseases. | ||||||||||||||||||||
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Isolaureline | Isolaureline can be isolated from the whole plant of Stephania longa. | |||||||||||||||||||||
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Stephanine | Stephanine ((-)-Stephanine) is an isoquinoline aporphine-type alkaloid. Stephanine induce apoptosis through the reverse of mitotic exit. Stephanine exhibits Antiplasmodial activity. Stephanine can be used for the research of stomach pain, abdominal pain, arthritis and cancer. | |||||||||||||||||||||
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Pukateine | Pukateine is a natural product. | |||||||||||||||||||||
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N-Fornzyl-annonain | N-Formzyl-annonain is an N-acylaporphine alkaloid that occurs in the stems of Tinospora crispa (Menispermaceae). | |||||||||||||||||||||
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(R)-1,2-Dihydroxyaporphine | (R)-1,2-Dihydroxyaporphine (Compound M1) is a metabolite of Nuciferine (HY-N0049) and is easily excreted through urine and feces. | |||||||||||||||||||||
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Aporeine | Aporeine (Aporheine) is an alkaloid that can be isolated from the aerial parts of p. rhoeas. | |||||||||||||||||||||
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Neolitsine | Neolitsine ((+)-Neolitsine) is a vasodilator. Neolitsine can be isolated from the herb Cassytha filiformis. Neolitsine exhibits significant vasodilatory effects on precontracted rat aortic preparations with an IC50 of 0.29 μM. | |||||||||||||||||||||
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Anonaine | 98.0% | Anonaine is an antiparasitic agent. Anonaine also is a glutathione S-transferase (GST) inhibitor. | ||||||||||||||||||||
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2-Hydroxy-1-Methoxyaporphine | 99.98% | 2-Hydroxy-1-Methoxyaporphine is an alkaloid that can be isolated from Nelumbo nucifera. 2-Hydroxy-1-Methoxyaporphine is the major active ingredient of the Chinese traditional medicine Jiang-Zhi-Ning. | ||||||||||||||||||||
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Cassythicine | Cassythicine is a Alkaloids product that can be isolated from the herbs of Litsea glutinosa. | |||||||||||||||||||||
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References
- [1]. M You, et al. (-)-Roemerine, an Aporphine Alkaloid From Annona Senegalensis That Reverses the Multidrug-Resistance Phenotype With Cultured Cells. J Nat Prod. 1995 Apr;58(4):598-604. [Content Brief]
- [2]. Xu J, et al. Inhibition of proliferation, migration and invasion of RM-1 cells by roemerine: Insights from in vitro and in vivo studies. Tissue Cell. 2024 Dec 20;93:102693. [Content Brief]
- [3]. Ma C, et al. Potent Activities of Roemerine against Candida albicans and the Underlying Mechanisms. Molecules. 2015 Sep 29;20(10):17913-28. [Content Brief]
- [4]. Bayazeid O, et al. Neuroactivity of the naturally occurring aporphine alkaloid, roemerine. Nat Prod Res. 2021 Dec;35(24):6147-6152. [Content Brief]
- [5]. Yin S, et al. Roemerine Improves the Survival Rate of Septicemic BALB/c Mice by Increasing the Cell Membrane Permeability of Staphylococcus aureus. PLoS One. 2015 Nov 25;10(11):e0143863. [Content Brief]
