475-83-2
475-83-2
Chemical Structure
Nuciferine
- CAS No.: 475-83-2
- Formula:C19H21NO2
- Molecular Weight:295.38
IUPAC Name: (R)-1,2-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline
InChIKey: ORJVQPIHKOARKV-OAHLLOKOSA-N
SMILES: CN1CCC2=CC(OC)=C(OC)C3=C2[C@@]1([H])CC4=CC=CC=C34
Biological Activity: Nuciferine is an antagonist at 5-HT2A (IC50=478 nM), 5-HT2C (IC50=131 nM), and 5-HT2B (IC50=1 μM), an inverse agonist at 5-HT7 (IC50=150 nM), a partial agonist at D2 (EC50=64 nM), D5 (EC50=2.6 μM) and 5-HT6 (EC50=700 nM), an agonist at 5-HT1A (EC50=3.2 μM) and D4 (EC50=2 μM) receptor.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Nuciferine | 99.90% | Nuciferine is an antagonist at 5-HT2A (IC50=478 nM), 5-HT2C (IC50=131 nM), and 5-HT2B (IC50=1 μM), an inverse agonist at 5-HT7 (IC50=150 nM), a partial agonist at D2 (EC50=64 nM), D5 (EC50=2.6 μM) and 5-HT6 (EC50=700 nM), an agonist at 5-HT1A (EC50=3.2 μM) and D4 (EC50=2 μM) receptor. | ||||||||||||||||||||
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Nuciferine (Standard) | ≥98% | Nuciferine (Standard) is the analytical standard of Nuciferine. This product is intended for research and analytical applications. Nuciferine is an antagonist at 5-HT2A (IC50=478 nM), 5-HT2C (IC50=131 nM), and 5-HT2B (IC50=1 μM), an inverse agonist at 5-HT7 (IC50=150 nM), a partial agonist at D2 (EC50=64 nM), D5 (EC50=2.6 μM) and 5-HT6 (EC50=700 nM), an agonist at 5-HT1A (EC50=3.2 μM) and D4 (EC50=2 μM) receptor. | ||||||||||||||||||||
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N-Acetylnornuciferine | N-Acetylnornuciferine is an aporphine alkaloid, whose family members possess potential antibacterial, antiviral, antioxidant, or anticancer activities. N-Acetylnornuciferine can be extracted from the dried roots of Liriodendron tulipifera (American tulip tree, a plant of the Magnoliaceae family) using ethanol. | |||||||||||||||||||||
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N-Formylnornuciferin | N-Formylnornuciferin is an N-acylaporphine alkaloid isolated from the stems of Tinospora crispa. N-Formylnornuciferin exhibits no scavenging activity against DPPH free radicals. | |||||||||||||||||||||
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N-Nornuciferine | 99.92% | N-Nornuciferine is an orally active, blood-brain barrier-permeable CYP2D6 inhibitor, with an IC50 of 3.76 μM and a Ki of 2.34 μM against human CYP2D6. N-Nornuciferine also acts as a BChE inhibitor, showing an IC50 of 5.6 μM in mice. N-Nornuciferine can be used in the research of neurological-related diseases. | ||||||||||||||||||||
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N-Nornuciferine hydrochloride | N-Nornuciferine hydrochloride is an orally active, blood-brain barrier-permeable CYP2D6 inhibitor, with an IC50 of 3.76 μM and a Ki of 2.34 μM against human CYP2D6. N-Nornuciferine hydrochloride also acts as a BChE inhibitor, showing an IC50 of 5.6 μM in mice. N-Nornuciferine hydrochloride can be used in the research of neurological-related diseases. | |||||||||||||||||||||
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Lirinidine | 99.83% | Lirinidine ((+)-Lirinidine) is an alkaloid isolated from the leaves of L. tulipifera and has antioxidant and anticancer activities. Lirinidine exhibits medium ferric reducing power activity and minor radical scavenging activity in vitro. Lirinidine can be used for cosmetic research. | ||||||||||||||||||||
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(R)-Lirinidine | (R)-Lirinidine ((-)-Lirinidine) is an aporphine-type alkaloid found in the flower buds and leaves of Nelumbo nucifera. (R)-Lirinidineand inhibits melanogenesis with an IC50 of 19.3 μM. (R)-Lirinidine exerts cytotoxic effects at 100 μM. | |||||||||||||||||||||
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N-Methylnuciferine | 98.29% | N-Methylnuciferine, an alkaloid from Lotus Plumule, ameliorate lipopolysaccharide-induced depression-like behavior. | ||||||||||||||||||||
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N-Methylnuciferine iodide | N-Methylnuciferine iodide, an alkaloid from Lotus Plumule, ameliorate lipopolysaccharide-induced depression-like behavior. | |||||||||||||||||||||
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O-Nornuciferine | 99.85% | O-Nornuciferine, an aporphine-type alkaloid from lotus leaf, is a potent hERG channel inhibitor. | ||||||||||||||||||||
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2-Hydroxy-1-Methoxyaporphine | 99.98% | 2-Hydroxy-1-Methoxyaporphine is an alkaloid that can be isolated from Nelumbo nucifera. 2-Hydroxy-1-Methoxyaporphine is the major active ingredient of the Chinese traditional medicine Jiang-Zhi-Ning. | ||||||||||||||||||||
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