Cat. No.: HY-N7511

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O-Nornuciferine

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O-Nornuciferine, an aporphine-type alkaloid from lotus leaf, is a potent hERG channel inhibitor.

For research use only. We do not sell to patients.

Purity: 99.85%
CAS No.: 3153-55-7
Formula: C₁₈H₁₉NO₂
Molecular Weight:281.35

Storage:

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

O-Nornuciferine Chemical Structure

CAS No.: 3153-55-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

O-Nornuciferine, an aporphine-type alkaloid from lotus leaf, is a potent hERG channel inhibitor^[1].

IC₅₀ & Target

Human Endogenous Metabolite

All Endogenous Metabolite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
B16-4A5	IC₅₀	14.5 μM Compound: 5	Inhibition of melanogenesis in mouse B16-4A5 cells after 72 hrs by spectrophotometry Inhibition of melanogenesis in mouse B16-4A5 cells after 72 hrs by spectrophotometry	[PMID: 23270663]

In Vitro

O-Nornuciferine has an IC₅₀ of 7.91 μM in vitro hERG blockages measured in HEK293 cells^[1].
O-Nornuciferine (100 μM) has 47% hERG channel inhibition in Xenopus oocytes by lotus alkaloids^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3153-55-7
Appearance Solid
Molecular Weight 281.35
Formula C₁₈H₁₉NO₂
Color White to off-white
SMILES

OC1=C(OC)C2=C3C(CCN(C)[C@]3([H])CC4=CC=CC=C24)=C1
Structure Classification
- Alkaloids
- Isoquinoline Alkaloids
- Phenols
- Monophenols
Initial Source
- Plants
- other families
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (177.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.5543 mL

17.7715 mL

35.5429 mL

5 mM

0.7109 mL

3.5543 mL

7.1086 mL

10 mM

0.3554 mL

1.7771 mL

3.5543 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ulrike Grienke, et al. Human Ether-à-go-go Related Gene (hERG) Channel Blocking Aporphine Alkaloids From Lotus Leaves and Their Quantitative Analysis in Dietary Weight Loss Supplements. J Agric Food Chem. 2015 Jun 17;63(23):5634-9. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.5543 mL	17.7715 mL	35.5429 mL	88.8573 mL
	5 mM	0.7109 mL	3.5543 mL	7.1086 mL	17.7715 mL
	10 mM	0.3554 mL	1.7771 mL	3.5543 mL	8.8857 mL
	15 mM	0.2370 mL	1.1848 mL	2.3695 mL	5.9238 mL
	20 mM	0.1777 mL	0.8886 mL	1.7771 mL	4.4429 mL
	25 mM	0.1422 mL	0.7109 mL	1.4217 mL	3.5543 mL
	30 mM	0.1185 mL	0.5924 mL	1.1848 mL	2.9619 mL
	40 mM	0.0889 mL	0.4443 mL	0.8886 mL	2.2214 mL
	50 mM	0.0711 mL	0.3554 mL	0.7109 mL	1.7771 mL
	60 mM	0.0592 mL	0.2962 mL	0.5924 mL	1.4810 mL
	80 mM	0.0444 mL	0.2221 mL	0.4443 mL	1.1107 mL
	100 mM	0.0355 mL	0.1777 mL	0.3554 mL	0.8886 mL

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O-Nornuciferine

Membrane Transporter/Ion Channel Compound Library

Metabolism/Protease Compound Library

Natural Product Library

Human Endogenous Metabolite Compound Library

Medicine Food Homology Compound Library

Phenols Library

Traditional Chinese Medicine Active Compound Library

Anti-Alzheimer's Disease Compound Library

Alkaloids Library

Neurodegenerative Disease-related Compound Library

Food-Sourced Compound Library

Plant-Sourced Natural Product Library

Potassium Channel Compound Library

Human Metabolite Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Animal-Sourced Natural Product Library

Ion Channel Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Tibetan Medicine Compound Library

Heat-Clearing and Detoxification Traditional Chinese Medicine Compound Library

RO5 Drug-like Natural Product Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Mass Spectrometry Human Endogenous Metabolite Library

Ancient Chinese Classical Formulas Traditional Chinese Medicine Active Compound Library

Mass Spectrometry Human Metabolite Library

Antitussive and Antiasthmatic Traditional Chinese Medicine Active Compound Library

Diarrhea-Related Traditional Chinese Medicine Active Compound Library

Cardiotoxic Compound Library

Mongolian Medicine Compound Library

Mass Spectrometry Natural Product Library

All Endogenous Metabolite Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

O-Nornuciferine Related Classifications

Cat. No.: HY-N7511