1. Metabolic Enzyme/Protease
  2. Cytochrome P450
  3. N-Nornuciferine


Cat. No.: HY-N2129 Purity: 99.38%
Handling Instructions

N-Nornuciferine is an aporphine alkaloid in lotus leaf that significantly inhibits CYP2D6 with IC50 and Ki of 3.76 and 2.34 μM, respectively.

For research use only. We do not sell to patients.

N-Nornuciferine Chemical Structure

N-Nornuciferine Chemical Structure

CAS No. : 4846-19-9

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Based on 1 publication(s) in Google Scholar

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N-Nornuciferine is an aporphine alkaloid in lotus leaf that significantly inhibits CYP2D6 with IC50 and Ki of 3.76 and 2.34 μM, respectively.

IC50 & Target

IC50: 3.76 μM (CYP2D6)[1]

Ki: 2.34 μM (CYP2D6)[1]

In Vitro

The herb of lotus leaves is a commonly used traditional Chinese medicine with a wide range of pharmacological and physiological activities, particularly the reduction of the blood triglyceride and cholesterol levels. N-Nornuciferine strongly inhibits CYP2D6 activity but shows weak or no inhibition of the other four P450 isoenzymes (CYP2C19, CYP3A4, CYP2E1, CYP2C9). N-Nornuciferine competitively inhibits the CYP2D6-catalyzed dextromethorphan o-demethylation with apparent Ki values of 2.34 μM[1].

Molecular Weight







COC1=C(OC)C2=C3C(CCN[[email protected]]3([H])CC4=CC=CC=C24)=C1


Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Kinase Assay

For the determination of the inhibition constant Ki values, various final concentrations of the specific substrate dextromethorphan for CYP2D6 in the range of 1 to 10 mM and different concentrations of the N-Nornuciferine in the range of 0 to 25 mM are used. After preincubation for 10 min, the reactions are initiated by the addition of NADPH. Each incubation test is performed in triplicate. Thirty minutes after the incubation is initiated, the reaction is stopped by the addition of 100 mL of ice-cold acetonitrile containing 1 mg/mL propranolol (IS). The incubation mixtures are then centrifuged at 15,000g for 10 min at 4 °C. Ten-microliter aliquots of the supernatants are injected into an LC-MS/MS system[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Purity: 99.38%

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