N-Nornuciferine hydrochloride
Based on 1 publication(s) in Google Scholar
N-Nornuciferine hydrochloride is an orally active, blood-brain barrier-permeable CYP2D6 inhibitor, with an IC50 of 3.76 μM and a Ki of 2.34 μM against human CYP2D6. N-Nornuciferine hydrochloride also acts as a BChE inhibitor, showing an IC50 of 5.6 μM in mice. N-Nornuciferine hydrochloride can be used in the research of neurological-related diseases.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 58546-00-2
- Formel: C18H20ClNO2
- Molecular Weight:317.81
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) N-Nornuciferine hydrochloride
More
Biologische Aktivität
|
CYP2D6 3.76 μM (IC50) |
CYP2D6 2.34 μM (Ki) |
BChE 5.6 μM (IC50) |
N-nornuciferine hydrochloride potently inhibits CYP2D6 in pooled human liver microsomes via competitive inhibition (IC50 = 3.76 μM, Ki = 2.34 μM), while it only exerts weak inhibitory effects on CYP2C19 (IC50 = 29 μM)[1].
N-Nornuciferine hydrochloride (Compound 5) is a BChE inhibitor with an IC50 of 5.6 μM in mice[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS. Nr. 58546-00-2
-
Molecular Weight 317.81
-
Formel C18H20ClNO2
-
SMILES
COC1=C2C3=C(C=C1OC)CCN[C@]3([H])CC4=CC=CC=C42.Cl
-
Structure Classification
-
Initial Source
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Carbohydr Polym
Metabolic degradation of lentinan in liver mediated by CYP450 enzymes and epoxide hydrolase. [Abstract]2021 Feb 1:253:117255. PMID: 33279005
Reinheit & Dokumentation
Verweise
[1]. Ye LH, et al. Identification and characterization of potent CYP2D6 inhibitors in lotus leaves. J Ethnopharmacol. 2014;153(1):190-196. [Content Brief]
[2]. Ye LH, et al. Pharmacokinetics of Nuciferine and N-Nornuciferine, Two Major Alkaloids From Nelumbo nucifera Leaves, in Rat Plasma and the Brain. Front Pharmacol. 2018 Aug 29;9:902. [Content Brief]
[3]. Cometa MF, et al. New cholinesterase inhibiting bisbenzylisoquinoline alkaloids from Abuta grandifolia. Fitoterapia. 2012 Apr;83(3):476-80. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
N-Nornuciferine hydrochloride Related Classifications
HY-N2129A Related Classifications
Powered by Bioz