N-Nornuciferine hydrochloride
Based on 1 publication(s) in Google Scholar
N-Nornuciferine hydrochloride is an orally active, blood-brain barrier-permeable CYP2D6 inhibitor, with an IC50 of 3.76 μM and a Ki of 2.34 μM against human CYP2D6. N-Nornuciferine hydrochloride also acts as a BChE inhibitor, showing an IC50 of 5.6 μM in mice. N-Nornuciferine hydrochloride can be used in the research of neurological-related diseases.
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- CAS No.: 58546-00-2
- 화학식: C18H20ClNO2
- 분자량:317.81
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Publications Citing Use of MedChemExpress (MCE) N-Nornuciferine hydrochloride
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Biological Activity
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CYP2D6 3.76 μM (IC50) |
CYP2D6 2.34 μM (Ki) |
BChE 5.6 μM (IC50) |
N-nornuciferine hydrochloride potently inhibits CYP2D6 in pooled human liver microsomes via competitive inhibition (IC50 = 3.76 μM, Ki = 2.34 μM), while it only exerts weak inhibitory effects on CYP2C19 (IC50 = 29 μM)[1].
N-Nornuciferine hydrochloride (Compound 5) is a BChE inhibitor with an IC50 of 5.6 μM in mice[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 58546-00-2
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분자량 317.81
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화학식 C18H20ClNO2
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SMILES
COC1=C2C3=C(C=C1OC)CCN[C@]3([H])CC4=CC=CC=C42.Cl
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Carbohydr Polym
Metabolic degradation of lentinan in liver mediated by CYP450 enzymes and epoxide hydrolase. [Abstract]2021 Feb 1:253:117255. PMID: 33279005
순도&문서
References
[1]. Ye LH, et al. Identification and characterization of potent CYP2D6 inhibitors in lotus leaves. J Ethnopharmacol. 2014;153(1):190-196. [Content Brief]
[2]. Ye LH, et al. Pharmacokinetics of Nuciferine and N-Nornuciferine, Two Major Alkaloids From Nelumbo nucifera Leaves, in Rat Plasma and the Brain. Front Pharmacol. 2018 Aug 29;9:902. [Content Brief]
[3]. Cometa MF, et al. New cholinesterase inhibiting bisbenzylisoquinoline alkaloids from Abuta grandifolia. Fitoterapia. 2012 Apr;83(3):476-80. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
N-Nornuciferine hydrochloride Related Classifications
HY-N2129A Related Classifications
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