N-Nornuciferine hydrochloride
Based on 1 publication(s) in Google Scholar
N-Nornuciferine hydrochloride is an orally active, blood-brain barrier-permeable CYP2D6 inhibitor, with an IC50 of 3.76 μM and a Ki of 2.34 μM against human CYP2D6. N-Nornuciferine hydrochloride also acts as a BChE inhibitor, showing an IC50 of 5.6 μM in mice. N-Nornuciferine hydrochloride can be used in the research of neurological-related diseases.
For research use only. We do not sell to patients.
- CAS No.: 58546-00-2
- Formula: C18H20ClNO2
- Molecular Weight:317.81
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) N-Nornuciferine hydrochloride
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Biological Activity
Description
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CYP2D6 3.76 μM (IC50) |
CYP2D6 2.34 μM (Ki) |
BChE 5.6 μM (IC50) |
In Vitro
N-nornuciferine hydrochloride potently inhibits CYP2D6 in pooled human liver microsomes via competitive inhibition (IC50 = 3.76 μM, Ki = 2.34 μM), while it only exerts weak inhibitory effects on CYP2C19 (IC50 = 29 μM)[1].
N-Nornuciferine hydrochloride (Compound 5) is a BChE inhibitor with an IC50 of 5.6 μM in mice[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 58546-00-2
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Molecular Weight 317.81
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Formula C18H20ClNO2
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SMILES
COC1=C2C3=C(C=C1OC)CCN[C@]3([H])CC4=CC=CC=C42.Cl
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Carbohydr Polym
Metabolic degradation of lentinan in liver mediated by CYP450 enzymes and epoxide hydrolase. [Abstract]2021 Feb 1:253:117255. PMID: 33279005
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
[1]. Ye LH, et al. Identification and characterization of potent CYP2D6 inhibitors in lotus leaves. J Ethnopharmacol. 2014;153(1):190-196. [Content Brief]
[2]. Ye LH, et al. Pharmacokinetics of Nuciferine and N-Nornuciferine, Two Major Alkaloids From Nelumbo nucifera Leaves, in Rat Plasma and the Brain. Front Pharmacol. 2018 Aug 29;9:902. [Content Brief]
[3]. Cometa MF, et al. New cholinesterase inhibiting bisbenzylisoquinoline alkaloids from Abuta grandifolia. Fitoterapia. 2012 Apr;83(3):476-80. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
N-Nornuciferine hydrochloride Related Classifications
HY-N2129A Related Classifications
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