N-Methylnuciferine
Based on 1 Customer Validation
N-Methylnuciferine, an alkaloid from Lotus Plumule, ameliorate lipopolysaccharide-induced depression-like behavior.
For research use only. We do not sell to patients.
- Purity : 98.29%
- CAS No.: 754919-24-9
- Formula: C20H24ClNO2
- Molecular Weight:345.86
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Chemical Information
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CAS No. 754919-24-9
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Appearance Solid
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Molecular Weight 345.86
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Formula C20H24ClNO2
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Color White to off-white
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SMILES
COC1=C2C3=C(C=C1OC)CC[N+](C)(C)[C@]3([H])CC4=CC=CC=C24.[Cl-]
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (289.13 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
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Protocol for Tail Suspension Test (TST)
The Tail Suspension Test is a mouse behavioral assay in which an animal is suspended by the tail in an inescapable position, causing alternating escape-directed activity and immobility; the main readout is immobility time, and antidepressant-like treatments generally reduce immobility compared with vehicle controls. The assay detects behavioral response to acute inescapable stress rather than a molecular event; immobility is interpreted as passive stress-coping behavior, while reduced immobility is used as a predictive screen for antidepressant-like activity, with important limitations related to strain, locomotor activity, and tail-climbing behavior.
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Protocol for Forced Swim Test (FST)
The Forced Swim Test is a rodent behavioral assay in which a mouse or rat is placed in an inescapable cylinder of water, and the main readout is the time spent immobile versus active escape-related behaviors such as swimming or climbing. Reduced immobility after treatment has historically been interpreted as antidepressant-like activity, but the assay should be interpreted as a behavioral response to acute inescapable stress rather than a complete model of human depression.
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Protocol for Sucrose Preference Test (SPT)
The Sucrose Preference Test is a rodent two-bottle choice assay used to estimate reward-related behavior by measuring preference for a sweet sucrose solution over water. Reduced sucrose preference is commonly interpreted as an anhedonia-like phenotype in stress-based depression models, but it can also be affected by thirst, hunger, body weight, learning, motivation, and general fluid intake.
Purity & Documentation
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Data Sheet (286 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8913 mL | 14.4567 mL | 28.9134 mL | 72.2836 mL |
| 5 mM | 0.5783 mL | 2.8913 mL | 5.7827 mL | 14.4567 mL | |
| 10 mM | 0.2891 mL | 1.4457 mL | 2.8913 mL | 7.2284 mL | |
| 15 mM | 0.1928 mL | 0.9638 mL | 1.9276 mL | 4.8189 mL | |
| 20 mM | 0.1446 mL | 0.7228 mL | 1.4457 mL | 3.6142 mL | |
| 25 mM | 0.1157 mL | 0.5783 mL | 1.1565 mL | 2.8913 mL | |
| 30 mM | 0.0964 mL | 0.4819 mL | 0.9638 mL | 2.4095 mL | |
| 40 mM | 0.0723 mL | 0.3614 mL | 0.7228 mL | 1.8071 mL | |
| 50 mM | 0.0578 mL | 0.2891 mL | 0.5783 mL | 1.4457 mL | |
| 60 mM | 0.0482 mL | 0.2409 mL | 0.4819 mL | 1.2047 mL | |
| 80 mM | 0.0361 mL | 0.1807 mL | 0.3614 mL | 0.9035 mL | |
| 100 mM | 0.0289 mL | 0.1446 mL | 0.2891 mL | 0.7228 mL |
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