Laurotetanine
Laurotetanine ((+)-Laurotetanine) is an potent and orally active isoquinoline alkaloid and could be extracted from the roots of Litsea cubeba (Lour.) Pers. Laurotetanine exerts an anti-asthmatic effect by inhibition of IgE, histamine, and inflammatory reactions via down-regulating MUC5AC and NF-κB signaling pathways.
For research use only. We do not sell to patients.
- CAS No.: 128-76-7
- Formula: C19H21NO4
- Molecular Weight:327.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RAW264.7 | IC50 |
>10 μM
Compound: 11
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Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced NO production pretreated for 30 mins followed by LPS stimulation for 24 hrs by Griess assay
Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced NO production pretreated for 30 mins followed by LPS stimulation for 24 hrs by Griess assay
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[PMID: 28499733] |
| Vero | CC50 |
165 μM
Compound: 3
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Cytotoxicity against african green monkey Vero cells
Cytotoxicity against african green monkey Vero cells
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[PMID: 9584402] |
| Vero | ED50 |
31 μM
Compound: 3
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Antiviral activity against Poliovirus 2 Sabin 2 infected in african green monkey Vero cells at 0.001 multiplicity of infection assessed as inhibition of virus-induced cytopathogenicity
Antiviral activity against Poliovirus 2 Sabin 2 infected in african green monkey Vero cells at 0.001 multiplicity of infection assessed as inhibition of virus-induced cytopathogenicity
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[PMID: 9584402] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague Dawley (SD) rats (180-220g) [1]
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Dosage:20, 40, and 60 mg/kg
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Administration:Oral administration; daily, for 21 days
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Result:Reduced inflammatory cells, including eosinophils, neutrophils, lymphocytes, and macrophages.
Decreased inflammatory cytokines viz IL-4, IL-6, IL-13 and increased IFN-γ.
Reduced serum IgE and histamine.
Decreased MUC5AC expression and increased NF-κB and IκB expression in lung tissues.
Chemical Information
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CAS No. 128-76-7
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Molecular Weight 327.37
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Formula C19H21NO4
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SMILES
OC1=C(C=C2C3=C4C(CCN[C@]4(CC2=C1)[H])=CC(OC)=C3OC)OC
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Synonyms
(+)-Laurotetanine
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Laurotetanine Related Classifications
HY-117616 Related Classifications
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