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Monocrotaline (Synonyms: Crotaline)

Cat. No.: HY-N0750 Purity: >98.0%
Handling Instructions

Monocrotaline is an pyrrolizidine alkaloid extracted from the seeds of the Crotalaria spectabilis plant to induce pulmonary hypertension in rodents.

For research use only. We do not sell to patients.

Monocrotaline Chemical Structure

Monocrotaline Chemical Structure

CAS No. : 315-22-0

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10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
50 mg USD 60 In-stock
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100 mg USD 96 In-stock
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200 mg USD 168 In-stock
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Based on 2 publication(s) in Google Scholar

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Description

Monocrotaline is an pyrrolizidine alkaloid extracted from the seeds of the Crotalaria spectabilis plant to induce pulmonary hypertension in rodents.

In Vitro

Monocrotaline (MCT) is an 11-membered macrocyclic pyrrolizidine alkaloid (PA) derived from the seeds of the Crotalaria spectabilis plant[1]. Monocrotaline a natural ligand exhibits dose-dependent cytotoxicity with potent antineoplastic activity. The in vitro cytotoxicity of monocrotaline is proved at IC50 24.966 µg/mL and genotoxicity at 2 X IC50 against HepG2 cells[2].

In Vivo

MCT causes a pulmonary vascular syndrome in rats characterized by proliferative pulmonary vasculitis, pulmonary hypertension (PH), and cor pulmonale[3]. Among preclinical models of pulmonary arterial hypertension (PAH), monocrotaline animal model offers the advantage of mimic several key aspects of human PAH, including vascular remodeling, proliferation of smooth muscle cells, endothelial dysfunction, upregulation of inflammatory cytokines, and right ventricle failure, requiring a single drug injection[4]. Changes in multiple pathways associated with the development of PH, including activated glycolysis, increased markers of proliferation, disruptions in carnitine homeostasis, increased inflammatory and fibrosis biomarkers, and a reduction in glutathione biosynthesis are observed with the injection of monocrotaline[5].

Clinical Trial
Molecular Weight

325.36

Formula

C₁₆H₂₃NO₆

CAS No.

315-22-0

SMILES

O=C(O[[email protected]]1([H])CCN2[[email protected]]1([H])C(CO3)=CC2)[[email protected]](C)[[email protected]@](C)(O)[[email protected]@](C)(O)C3=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 37.5 mg/mL (115.26 mM; Need ultrasonic)

H2O : 4 mg/mL (12.29 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0735 mL 15.3676 mL 30.7352 mL
5 mM 0.6147 mL 3.0735 mL 6.1470 mL
10 mM 0.3074 mL 1.5368 mL 3.0735 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.68 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.68 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.68 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: >98.0%

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KeyWords:

Monocrotaline | Crotaline | Others | Inhibitor | inhibitor | inhibit

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Monocrotaline
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HY-N0750
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