SIRT3

SIRT3 Related Products (23)
Antibodies (1)

SIRT3 Related Products (23):

By Type:	Pan (18) Selective (2)
By Effects:	Inhibitors (15) Activators (6)

Cat. No.	Product Name	Effect	Purity

HY-123033A

Nicotinamide riboside chloride	Activator	99.59%
Nicotinamide riboside Chloride, an orally active NAD⁺ precursor, increases NAD⁺ levels and activates SIRT1 and SIRT3. Nicotinamide riboside Chloride is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside Chloride reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease.

HY-108331

3-TYP	Inhibitor	99.90%
3-TYP is an inhibitor of SIRT3 (IC₅₀: ~377 μM) and an inhibitor of Methionine Adenosyltransferase (MAT) 2 and Indoleamine 2,3-Dioxygenase (IDO). There may be many off-target sites for 3-TYP that need to be examined, such as NAD-dependent enzymes, including dehydrogenases.

HY-100578

AGK2	Inhibitor	99.62%
AGK2 is a selective SIRT2 inhibitor with an IC₅₀ of 3.5 μM. AGK2 inhibits SIRT1 and SIRT3 with IC₅₀s of 30 and 91 μM, respectively.

HY-15510

Tenovin-6	Inhibitor	98.33%
Tenovin-6, an analog of Tenovin-1 (HY-13423), is an activator of p53 transcriptional activity. Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 with IC₅₀s of 21 μM, 10 μM, and 67 μM, respectively. Tenovin-6 also inhibits dihydroorotate dehydrogenase (DHODH).

HY-B0130A

Perindopril erbumine		99.98%
Perindopril erbumine is an angiotensin-converting enzyme inhibitor. Perindopril erbumine modulates NF-κB and STAT3 signaling and inhibits glial activation and neuroinflammation. Perindopril erbumine can be used for the research of Chronic Kidney Disease and high blood pressure.

HY-160617

SIRT2-IN-14	Inhibitor
SIRT2-IN-14 (Compound 78) is a selectve inhibitor for SIRT2 with an IC₅₀ of 0.196 μM.

HY-N6675

Gardenia yellow	Activator
Gardenia yellow is an active member of crocin, increases mRNA expression of SIRT3, and acts as an orally active antidepressant agent.

HY-136199

SIRT1-IN-1	Inhibitor	98.19%
SIRT1-IN-1 is a selective SIRT1 inhibitor with an IC₅₀ of 0.205 μM. SIRT1-IN-1 inhibits SIRT2 with an IC₅₀ of 11.5 μM. SIRT1-IN-1, a indole, is a cytomegalovirus (CMV) inhibitors and has antiviral activity.

HY-15510B

Tenovin-6 Hydrochloride	Inhibitor	≥98.0%
Tenovin-6 Hydrochloride, an analog of Tenovin-1 (HY-13423), is an activator of p53 transcriptional activity. Tenovin-6 Hydrochloride inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 with IC₅₀s of 21 μM, 10 μM, and 67 μM, respectively. Tenovin-6 Hydrochloride also inhibits dihydroorotate dehydrogenase (DHODH).

HY-16616

SIRT-IN-2	Inhibitor	98.56%
SIRT-IN-2 is a potent inhibitor of SIRT1/2/3, with IC₅₀s of 4, 4, 7 μM, respectively.

HY-16615

SIRT-IN-1	Inhibitor	98.58%
SIRT-IN-1 is a potent inhibitor of SIRT1/2/3, with IC₅₀s of 15, 10, 33 μM, respectively.

HY-151519

SIRT2-IN-9	Inhibitor	99.45%
SIRT2-IN-9 (compound 12) is a selective inhibitor of SRIT2 with an IC₅₀ value of 1.3 μM. SIRT2-IN-9 inhibits proliferative activity of MCF-7 breast cancer cells. SIRT2-IN-9 can be used for the research of cancer.

HY-123033

Nicotinamide riboside	Activator
Nicotinamide riboside, an orally active NAD⁺ precursor, increases NAD⁺ levels and activates SIRT1 and SIRT3. Nicotinamide riboside is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease.

HY-111329

JGB1741	Inhibitor	99.05%
JGB1741 (ILS-JGB-1741) is a potent and specific SIRT1 activity inhibitor with an IC₅₀ of ∼15 μM. JGB1741 is a weak SIRT2 and SIRT3 inhibitor with an all IC₅₀>100 μM. JGB1741 increases the acetylated p53 levels leading to p53-mediated apoptosis with modulation of Bax/Bcl2 ratio, cytochrome c release and PARP cleavage. JGB1741 has the potential for breast cancer research.

HY-B0130

Perindopril		98.01%
Perindopril erbumine is an angiotensin-converting enzyme inhibitor. Perindopril erbumine modulates NFκB and STAT3 signaling and inhibits glial activation and neuroinflammation. Perindopril erbumine can be used for the research of Chronic Kidney Disease and high blood pressure.

HY-111303

CHIC35	Inhibitor
CHIC35, an analog of EX-527, is a potent and selective inhibitor of SIRT1 (IC₅₀=0.124 µM). CHIC35 shows potential selective inhibition against SIRT1 over SIRT2 (IC₅₀=2.8 µM) or SIRT3 (IC₅₀>100 µM). CHIC35 has anti-inflammatory effects and can be used for CHARGE syndrome research.

HY-155784

SPC-180002	Inhibitor
SPC-180002 is a SIRT1/3 dual inhibitor, with IC₅₀ values of 1.13 and 5.41 μM, respectively. SPC-180002 disturbs redox homeostasis via ROS generation, which leads to an increase in both p21 protein stability and mitochondrial dysfunction. SPC-180002 strongly inhibits cell cycle progression and cancer cell growth. SPC-180002 activates the Nrf2 signaling pathway.

HY-118343

AC-93253	Inhibitor
AC-93253 is a selective, potent SIRT2 inhibitor. AC93253 can inhibit SIRT2 with an IC₅₀ value of 6 μM. AC93253 can be used for the research of tumors.

HY-150727

SIRT5 inhibitor 4	Inhibitor
SIRT5 inhibitor 4 (compound 11) is a potent, selective SIRT5 inhibitor with IC₅₀ values of 26.4 and >400μM for SIRT5 and other SIRT subtype, respectively.

HY-123033B

Nicotinamide riboside tartrate	Activator
Nicotinamide riboside tartrate, an orally active NAD⁺ precursor, increases NAD⁺ levels and activates SIRT1 and SIRT3. Nicotinamide riboside tartrate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside tartrate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease.

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SIRT3

SIRT3 Related Products (23)

Antibodies (1)

SIRT3 Related Products (23):