Perindopril erbumine
Based on 8 publication(s) in Google Scholar
Perindopril erbumine is an angiotensin-converting enzyme inhibitor. Perindopril erbumine modulates NF-κB and STAT3 signaling and inhibits glial activation and neuroinflammation. Perindopril erbumine can be used for the research of Chronic Kidney Disease and high blood pressure.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.98%
- No. CAS: 107133-36-8
- Fòrmula: C23H43N3O5
- Peso molecular:441.60
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Almacenamiento:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Captopril (Standard)
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HY-B0130AR
Perindopril erbumine (Standard)
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Publications Citing Use of MedChemExpress (MCE) Perindopril erbumine
More- J Biomed Sci. 2025 Dec 12;32(1):104. [Abstract]
- Phytomedicine. 2024 Dec:135:156187. [Abstract]
- Stem Cell Res Ther. 2024 Oct 23;15(1):375. [Abstract]
- Br J Pharmacol. 2021 Mar;178(5):1164-1181. [Abstract]
- Life Sci. 2026 Aug 15:399:124472. [Abstract]
- Biosci Rep. 2021 Oct 29;41(10):BSR20211598. [Abstract]
- Biomed Pharmacother. 2023 Apr:160:114370. [Abstract]
- Evid Based Complement Alternat Med. 2022 May 21;2022:5812105. [Abstract]
Actividad biológica
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SIRT3 |
STAT3 |
Perindopril erbumine (1 μM, 24 h) ameliorats gliosis and blunts decrease induced by LPS (HY-D1056) in AT2R expression in Rat astrocytoma cell line (C6) and murine microglial cell line (BV2)[1].
Perindopril erbumine (1 μM, 24 h) prevents IκBα degradation, NF-кB nuclear translocation and STAT3 activation induced by LPS (HY-D1056) in C6 and BV2[1].
Perindopril erbumine (1 μM, 24 h) ameliorats the imbalance in the release of inflammatory cytokine and blunts the aberrant ROS production and the nitrite release induced by LPS (HY-D1056) in C6 and BV2[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Perindopril erbumine (0.42 mg/kg, Oral, once a day for 4 weeks) with Huangqi-Danshen decoction (HDD) (4.7 g/kg, Oral, once a day for 4 weeks) attenuates adenine(HY-B0152)-induced Chronic kidney disease (CKD) in rats[2].
Perindopril erbumine (0.4-1.5 mg/kg, Oral, once a day for 4-24 weeks) has a persistent effect on blood pressure in spontaneously hypertensive rats (SHR)[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adenine-induced chronic kidney disease rats[2]
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Dosage:0.1 mg/kg
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Administration:Oral gavage (p.o.)
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Result:Abolished the LPS-induced astroglial and microglial activation.
Attenuated LPS-induced TNF-α production.
Prevented LPS-induced nuclear translocation of NF-кB.
Prevented the AT1R up-regulation and the LPS-induced decrease in the expression of PP2A.
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Animal Model:Chronic kidney disease rats[2]
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Dosage:0.42 mg/kg
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Administration:Oral
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Result:Obviously reduced serum creatinine (Scr) and blood urea nitrogen (BUN) levels.
Displayed a marked reduction of tubulointerstitial fibrosis.
Exhibited more inhibitory effect on Col-IV expression and a exceed effect of raising OPA-1 expression.
Significantly increased Sirtuin3 expression.
Prevented mitochondrial fragmentation.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 107133-36-8
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Appearance Solid
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Peso molecular 441.60
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Fòrmula C23H43N3O5
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Color White to off-white
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SMILES
O=C([C@H]1N(C([C@@H](N[C@H](C(OCC)=O)CCC)C)=O)[C@@]2([H])CCCC[C@@]2([H])C1)O.CC(C)(C)N
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Synonyms
Perindopril (tert-butylamine salt); S-9490 erbumine
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (8)
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Journal Impact Factor
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Most Recent
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J Biomed Sci
Immune cell uptake of glycinated nanoparticles conjugated to anti-fibrotic peptides enables their prolonged activity and oral administration. [Abstract]2025 Dec 12;32(1):104. PMID: 41382190 -
Phytomedicine
Huangqi-Danshen decoction improves heart failure by regulating pericardial adipose tissue derived extracellular vesicular miR-27a-3p to activate AMPKα2 mediated mitophagy. [Abstract]2024 Dec:135:156187. PMID: 39488874 -
Stem Cell Res Ther
The renoprotective efficacy and safety of genetically-engineered human bone marrow-derived mesenchymal stromal cells expressing anti-fibrotic cargo. [Abstract]2024 Oct 23;15(1):375. PMID: 39443975 -
Br J Pharmacol
Combining mesenchymal stem cells with serelaxin provides enhanced renoprotection against 1K/DOCA/salt-induced hypertension. [Abstract]2021 Mar;178(5):1164-1181. PMID: 33450051 -
Life Sci
Serelaxin has greater anti-fibrotic potential than perindopril but maintains its anti-fibrotic efficacy in the presence of perindopril in normotensive mouse models of heart disease. [Abstract]2026 Aug 15:399:124472. PMID: 42176886 -
Biosci Rep
Jian-Pi-Yi-Shen formula enhances perindopril inhibition of chronic kidney disease progression by activation of SIRT3, modulation of mitochondrial dynamics, and antioxidant effects. [Abstract]2021 Oct 29;41(10):BSR20211598. PMID: 34633033 -
Biomed Pharmacother
The single-chain relaxin mimetic, B7-33, maintains the cardioprotective effects of relaxin and more rapidly reduces left ventricular fibrosis compared to perindopril in an experimental model of cardiomyopathy. [Abstract]2023 Apr:160:114370. PMID: 36753958 -
Evid Based Complement Alternat Med
Combination of Perindopril Erbumine and Huangqi-Danshen Decoction Protects Against Chronic Kidney Disease via Sirtuin3/Mitochondrial Dynamics Pathway. [Abstract]2022 May 21;2022:5812105. PMID: 35677375
Solvente y solubilidad
H2O : ≥ 50 mg/mL (113.22 mM)
DMSO : 10 mg/mL (22.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (226.45 mM); Clear solution; Need ultrasonic
Pureza y Documentación
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Ficha de datos (281 KB)
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SDS (557 KB)
- English - EN (557 KB)
- Français - FR (557 KB)
- Deutsch - DE (557 KB)
- Norwegian - NO (557 KB)
- Español - ES (557 KB)
- Swedish - SV (557 KB)
- Italian - IT (557 KB)
- Korean - KR (557 KB)
- Portuguese - PT (557 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Bhat S A, et al. Angiotensin receptor blockade modulates NFκB and STAT3 signaling and inhibits glial activation and neuroinflammation better than angiotensin-converting enzyme inhibition [J]. Molecular neurobiology, 2016, 53: 6950-6967. [Content Brief]
[2]. Wei X, et al. Combination of perindopril erbumine and huangqi-danshen decoction protects against chronic kidney disease via sirtuin3/mitochondrial dynamics pathway [J]. Evidence-Based Complementary and Alternative Medicine, 2022, 2022. [Content Brief]
[3]. Afonso T, et al. Pharmacodynamic evaluation of 4 angiotensin‐converting enzyme inhibitors in healthy adult horses [J]. Journal of veterinary internal medicine, 2013, 27(5): 1185-1192. [Content Brief]
[4]. Thybo N K, et al. Dose-dependent effects of perindopril on blood pressure and small-artery structure [J]. Hypertension, 1994, 23(5): 659-666. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 2.2645 mL | 11.3225 mL | 22.6449 mL | 56.6123 mL |
| 5 mM | 0.4529 mL | 2.2645 mL | 4.5290 mL | 11.3225 mL | |
| 10 mM | 0.2264 mL | 1.1322 mL | 2.2645 mL | 5.6612 mL | |
| 15 mM | 0.1510 mL | 0.7548 mL | 1.5097 mL | 3.7742 mL | |
| 20 mM | 0.1132 mL | 0.5661 mL | 1.1322 mL | 2.8306 mL | |
| H2O | 25 mM | 0.0906 mL | 0.4529 mL | 0.9058 mL | 2.2645 mL |
| 30 mM | 0.0755 mL | 0.3774 mL | 0.7548 mL | 1.8871 mL | |
| 40 mM | 0.0566 mL | 0.2831 mL | 0.5661 mL | 1.4153 mL | |
| 50 mM | 0.0453 mL | 0.2264 mL | 0.4529 mL | 1.1322 mL | |
| 60 mM | 0.0377 mL | 0.1887 mL | 0.3774 mL | 0.9435 mL | |
| 80 mM | 0.0283 mL | 0.1415 mL | 0.2831 mL | 0.7077 mL | |
| 100 mM | 0.0226 mL | 0.1132 mL | 0.2264 mL | 0.5661 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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