Sirtuin Inhibitors

Sirtuin

SIRT1

SIRT2

SIRT3

SIRT6

SIRT5

SIRT7

SIRT4

Sirtuin Inhibitors, Agonists, Activators, Modulators, Degraders, Controls & Substrates

Product Name	Sirtuin	SIRT1	SIRT2	SIRT3	SIRT6	SIRT5	SIRT7	SIRT4	Purity
Nicotinamide		SIRT1, IC₅₀: 50-180 μM	SIRT2, EC₅₀: 2 μM						99.98%
Nicotinamide riboside chloride		SIRT1		SIRT3					99.90%
3-TYP				SIRT3, IC₅₀: 38 μM					99.90%
SIRT6-IN-6		SIRT1, IC₅₀: >200 μM	SIRT2, IC₅₀: >200 μM	SIRT3, IC₅₀: >200 μM	SIRT6, IC₅₀: 4.93 μM				98.59%
Ac-QPKK(Ac)-AMC acetate		SIRT1	SIRT2	SIRT3	SIRT6				99.38%
Suramin sodium salt		SIRT1, IC₅₀: 297 nM	SIRT2, IC₅₀: 1.15 μM			SIRT5, IC₅₀: 22 μM			99.98%
SRT 1720		SIRT1, EC1.5: 0.16 μM	SIRT2, EC1.5: 37 μM						99.90%
AGK2		SIRT1, IC₅₀: 30 μM	SIRT2, IC₅₀: 3.5 μM	SIRT3, IC₅₀: 91 μM					99.43%
Gamma-glutamylcysteine		SIRT1		SIRT3					98.53%
OSS_128167		SIRT1, IC₅₀: 1578 μM	SIRT2, IC₅₀: 751 μM		SIRT6, IC₅₀: 89 μM				98.92%
SRT 2104		SIRT1							99.27%
2-APQC				SIRT3, Kd: 2.756					99.70%
Resveratrol (Standard)	Sirtuin
SIRT7 inhibitor 97491							SIRT7, IC₅₀: 325 nM		98.81%
Sirtinol		ySir2, IC₅₀: 48 μM hSIRT1, IC₅₀: 131 μM	hSIRT2, IC₅₀: 57.7 μM						98.0%
SirReal2			SIRT2, IC₅₀: 140 nM						99.0%
UBCS039					SIRT6, EC₅₀: 38 μM				98.88%
Geniposidic acid					SIRT6, Kd: 6.751 × 10 μM				98.87%
Sweroside		SIRT1							99.76%
Perindopril				SIRT3					99.85%
SRT 1460		SIRT1, EC1.5: 2.9 μM							98.16%
AK-7			SIRT2, IC₅₀: 15.5 μM						99.63%
Agrimol B		SIRT1							99.75%
SIRT4-IN-1								hSIRT4, IC₅₀: 16 nM	99.94%
Tenovin-6		SIRT1, IC₅₀: 21 μM	SIRT2, IC₅₀: 10 μM	SIRT3, IC₅₀: 67 μM					98.00%
Cambinol		SIRT1, IC₅₀: 56 μM	SIRT2, IC₅₀: 59 μM						99.89%
SRT 1720 dihydrochloride		SIRT1, EC₅₀: 0.10 μM							99.60%
Nicotinamide (Standard)			SIRT2
SRT 1720 monohydrochloride		SIRT1, EC1.5: 0.16 μM SIRT1, EC₅₀: 0.10 μM	SIRT2, EC1.5: 37 μM						99.92%
Thiomyristoyl		SIRT1, IC₅₀: 98 μM	SIRT2, IC₅₀: 28 nM						98.23%
MDL-800					SIRT6, EC₅₀: 10.3 μM				99.11%
Ganoderic acid D				SIRT3					99.89%
2"-O-Galloylhyperin		SIRT1							99.57%
Et-29						SIRT5, Ki: 40 nM			99.89%
Inauhzin		SIRT1							98.46%
Scopolin		SIRT1							99.65%
SIRT6 activator 12q					SIRT6, EC1.5: 0.58 μM				99.83%
Phellopterin				SIRT3					99.94%
Tenovin-1	Sirtuin								99.88%
Tetramethyluric acid				SIRT3					99.63%
Perindopril erbumine				SIRT3					99.98%
Salermide		SIRT1	SIRT2						98.0%
SIRT1-IN-1		SIRT1, IC₅₀: 0.205 μM	SIRT2, IC₅₀: 11.5 μM	SIRT3, IC₅₀: >100 μM					98.15%
SIRT-IN-2		SIRT1, IC₅₀: 4 nM	SIRT2, IC₅₀: 1 nM	SIRT3, IC₅₀: 7 nM					98.08%
SRT 2183		SIRT1, EC1.5: 0.36 μM							98.06%
SIRT6-IN-2		SIRT1, IC₅₀: 783 μM	SIRT2, IC₅₀: 453 μM		SIRT6, IC₅₀: 34 μM				99.92%
PROTAC Sirt2 Degrader-1			SIRT2, IC₅₀: 0.25 μM						99.09%
SIRT5 inhibitor 3						SIRT5, IC₅₀: 5.9 μM			98.0%
Palmitoyl tetrapeptide-20		SIRT1							99.21%
5-Heptadecylresorcinol				SIRT3					99.83%
Tenovin-6 Hydrochloride		SIRT1, IC₅₀: 21 μM	SIRT2, IC₅₀: 10 μM	SIRT3, IC₅₀: 67 μM					98.88%
Loliolide		SIRT1							99.92%
NSC 90469		SIRT1							99.41%
CAY10602		SIRT1							98.69%
MDL-811					SIRT6, EC₅₀: 5.7 μM				99.68%
Segetalin B		SIRT1							99.56%
Dihydrocoumarin		hSIRT1, IC₅₀: 208 μM	hSIRT2, IC₅₀: 295 μM						99.81%
Schisanhenol		SIRT1							99.99%
8-Prenylnaringenin		SIRT1							99.63%
SIRT3 activator 2				SIRT3					98.94%
YZL-51N							SIRT7, IC₅₀: 12.71 μM
Lumbokinase		SIRT1
AK-1			SIRT2, IC₅₀: 12.5 μM						99.84%
4-Hydroxyestrone		SIRT1							≥99.0%
SIRT1-IN-4		SIRT1, IC₅₀: 10.04 μM							98.62%
4'-Bromo-resveratrol		SIRT1, IC₅₀: 0.2 mM		SIRT3, IC₅₀: 0.2 mM					99.94%
SKLB-11A				SIRT3, Kd: 4.7 μM					99.40%
Sirtuin modulator 1		SIRT1, EC1.5: 1 μM							99.85%
(S)-Selisistat		SIRT1, IC₅₀: 98 nM							99.39%
SIRT3-IN-1				SIRT3, IC₅₀: 0.043 μM					98.47%
E1231		SIRT1, EC₅₀: 0.83 μM							98.46%
SIRT-IN-1		SIRT1, IC₅₀: 15 nM	SIRT2, IC₅₀: 10 nM	SIRT3, IC₅₀: 33 nM					98.14%
Ophiopogonin D'		SIRT1							99.94%
Sirt2-IN-1			SIRT2, IC₅₀: 163 nM						98.71%
Myricanol		SIRT1							98.93%
Nicotinamide riboside malate		SIRT1		SIRT3					98.04%
SIRT2-IN-8			SIRT2						98.45%
RK-9123016			SIRT2, IC₅₀: 0.18 μM						99.65%
SirReal-1			SIRT2, IC₅₀: 3.7 μM						99.82%
SIRT1-IN-2		SIRT1, IC₅₀: 1.6 μM	SIRT2, IC₅₀: 39 μM						98.31%
SIRT6-IN-3		SIRT1, IC₅₀: 80.52 μM	SIRT2, IC₅₀: 92.21 μM		SIRT6, IC₅₀: 7.46 μM				98.19%
SIRT1-IN-3		SIRT1, IC₅₀: 4.2 μM	SIRT2, IC₅₀: 38 μM						99.12%
JGB1741		SIRT1, IC₅₀: ∼15 μM	SIRT2, IC₅₀: >100 μM	SIRT3, IC₅₀: >100 μM					99.37%
Suramin		SIRT1, IC₅₀: 297 nM	SIRT2, IC₅₀: 1.15 μM			SIRT5, IC₅₀: 22 μM
YK-3-237		SIRT1							99.54%
Tanshindiol C		SIRT1							98.47%
Tenovin-3				SIRT3					98.0%
SIRT5 inhibitor 4		SIRT1, IC₅₀: ＞400 μM	SIRT2, IC₅₀: ＞400 μM	SIRT3, IC₅₀: ＞400 μM	SIRT6, IC₅₀: ＞400 μM	SIRT5, IC₅₀: 26.4 μM	SIRT7, IC₅₀: ＞400 μM		98.37%
Nicotinamide riboside tartrate		SIRT1		SIRT3					98.07%
SIRT2-IN-9		SIRT1, IC₅₀: ＞300 μM	SIRT2, IC₅₀: 1.3 μM	SIRT3, IC₅₀: ＞300 μM					99.45%
FLS-359			SIRT2, IC₅₀: 3 μM
MitoPBN				SIRT3
Sirtuin-1 inhibitor 1		SIRT1							98.09%
Palmitoyl tetrapeptide-20 TFA		SIRT1
SIRT2-IN-11		SIRT1, IC₅₀: 118.4 μM	SIRT2, IC₅₀: 18.5 μM						99.94%
AC-93253		SIRT1, IC₅₀: 45.3 μM	SIRT2, IC₅₀: 6 μM	SIRT3, IC₅₀: 24.6 μM					99.3%
MIND4-19			SIRT2, IC₅₀: 7.0 μM						99.93%
SIRT1 activator 2		SIRT1, ED₅₀: <5 μM							99.28%
CrBKA					SIRT6				98.46%
Nicotinamide riboside		SIRT1		SIRT3
β-Patchoulene		SIRT1
CHIC35		SIRT1, IC₅₀: 0.124 μM	SIRT2, IC₅₀: 2.8 μM	SIRT3, IC₅₀: >100 μM
SIRT1/2/3-IN-2		SIRT1	SIRT2	SIRT3
Sirt2-IN-5			SIRT2
SPC-180002		SIRT1, IC₅₀: 1.13 ± 0.3 μM		SIRT3, IC₅₀: 5.41 ± 4.8 μM
NH4-6		SIRT1, IC₅₀: 3 μM	SIRT2, IC₅₀: 0.032 μM
Sirt1/2-IN-5		hSIRT1, IC₅₀: 0.3 μM	hSIRT2, IC₅₀: 1.2 μM hSIRT2, pIC₅₀: 5.82
Epigenetic factor-IN-1							SIRT7
SIRT6-IN-5					SIRT6
NCO-141			SIRT2, IC₅₀: 0.5 μM
Sirt2-IN-6			SIRT2, IC₅₀: 0.815 μM
Nicotinamide hydrochloride		SIRT1, IC₅₀: 50-180 μM	SIRT2, EC₅₀: 2 μM
hsa62		SIRT1, IC₅₀: 1.3 μM	SIRT2, IC₅₀: 5.5 μM	SIRT3, IC₅₀: 43.6 μM
DCHC		SIRT1
PROTAC Sirt2 Degrader-2			SIRT2
C1A				SIRT3, IC₅₀: 55 μM
SIRT5 inhibitor 5						SIRT5, IC₅₀: 0.21 μM
SIRT6 activator 2					SIRT6
Gypenoside CII		hSIRT1
SIRT6 activator 3					SIRT6, EC₅₀: 5 μM
Sirt1/2-IN-1		SIRT1, IC₅₀: 1.81 μg/mL	SIRT2, IC₅₀: 2.10 μg/mL	SIRT3, IC₅₀: 20.5 μg/mL
Sirtuin-IN-1		SIRT1, IC₅₀: 6.2 μM	SIRT2, IC₅₀: 4.2 μM
Sirtuin modulator 4		SIRT1, EC₅₀: 51-100 μM
SIRT1-IN-5		SIRT1
SIRT2-IN-14		SIRT1, IC₅₀: >200 μM	SIRT2, IC₅₀: 0.196 μM	SIRT3, IC₅₀: 85.8 μM
SIRT5 inhibitor 2						SIRT5, IC₅₀: 2.3 μM
NCO-90			SIRT2, IC₅₀: 1.0 μM
SIRT1 activator 4		SIRT1
Altissimacoumarin F		SIRT1
Sirtuin modulator 5		SIRT1, DC₅₀: ＜50 μM
SL010110			SIRT2
Sirtuin-IN-2						SIRT5
SR94			SIRT2
IMU-856					SIRT6
HSP70/SIRT2-IN-1			SIRT2, IC₅₀: 17.3±2.0 μM
Butrin		SIRT1
SIRT5-IN-10						SIRT5
SIRT6-IN-4		SIRT1, IC₅₀: 311.9 μM	SIRT2, IC₅₀: 157.2 μM	SIRT3, IC₅₀: 274.1 μM	SIRT6, IC₅₀: 5.86 μM
PRMT/HKMT-IN-1		SIRT1	SIRT2
BF-175		SIRT1
Cudraflavone B		SIRT1
ZINC08792229		SIRT1
SIRT3-IN-2				SIRT3
3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol		SIRT1
A2B57			SIRT2, IC₅₀: 6.3 μM
SIRT-IN-6		SIRT1, IC₅₀: >50 μM	SIRT2, IC₅₀: >50 μM	SIRT3, IC₅₀: >50 μM
SIRT2-IN-18			hSIRT2, IC₅₀: 12.3 μM Schistosoma mansoniSIRT2, IC₅₀: 5.3 μM
A1B11			SIRT2, IC₅₀: 5.3 μM
Arecaidine-propargyl ester		SIRT1
Sweroside (Standard)		SIRT1
Sudachitin		SIRT1
2"-O-Galloylhyperin (Standard)		SIRT1

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