1. Signaling Pathways
  2. Cell Cycle/DNA Damage
    Epigenetics
  3. Sirtuin
  4. Sirtuin Inhibitors

Sirtuin Inhibitors

Sirtuin

SIRT1

SIRT2

SIRT3

SIRT6

SIRT5

SIRT7

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

Sirtuin Inhibitors, Activators & Modulators
Product Name Sirtuin SIRT1 SIRT2 SIRT3 SIRT6 SIRT5 SIRT7 Purity
Nicotinamide    
SIRT2, EC50: 2 μM
        99.86%
Nicotinamide riboside chloride  
SIRT1
 
SIRT3
      99.53%
3-TYP  
SIRT1, IC50: 88 nM
SIRT2, IC50: 92 nM
SIRT3, IC50: 16 nM
      99.93%
SIRT2-IN-8    
SIRT2
       
SIRT1-IN-2  
SIRT1, IC50: 1.6 μM
SIRT2, IC50: 39 μM
       
OSS_128167  
SIRT1, IC50: 1578 μM
SIRT2, IC50: 751 μM
 
SIRT6, IC50: 89 μM
    98.06%
SRT 1720 Hydrochloride  
SIRT1, EC1.5: 0.16 μM
SIRT1, EC50: 0.10 μM
SIRT2, EC1.5: 37 μM
        99.92%
Suramin sodium salt  
SIRT1, IC50: 297 nM
SIRT2, IC50: 1.15 μM
   
SIRT5, IC50: 22 μM
  ≥98.0%
UBCS039        
SIRT6, EC50: 38 μM
    98.80%
SRT 1720  
SIRT1, EC1.5: 0.16 μM
SIRT2, EC1.5: 37 μM
        99.82%
SRT 2104  
SIRT1
          99.76%
AGK2  
SIRT1, IC50: 30 μM
SIRT2, IC50: 3.5 μM
SIRT3, IC50: 91 μM
      99.62%
Sirtinol  
ySir2, IC50: 48 μM
hSIRT1, IC50: 131 μM
hSIRT2, IC50: 57.7 μM
        ≥98.0%
SIRT7 inhibitor 97491            
SIRT7, IC50: 325 nM
98.05%
Thiomyristoyl  
SIRT1, IC50: 98 μM
SIRT2, IC50: 28 nM
        98.37%
Tenovin-6  
SIRT1, IC50: 21 μM
SIRT2, IC50: 10 μM
SIRT3, IC50: 67 μM
      98.67%
Ganoderic acid D      
SIRT3
      99.81%
SRT 2183  
SIRT1, EC1.5: 0.36 μM
          98.17%
Cambinol  
SIRT1, IC50: 56 μM
SIRT2, IC50: 59 μM
        99.70%
SRT 1460  
SIRT1, EC1.5: 2.9 μM
          98.92%
Gardenia yellow      
SIRT3
     
CAY10602  
SIRT1
          98.65%
AK-7    
SIRT2, IC50: 15.5 μM
        99.93%
PROTAC Sirt2 Degrader-1    
SIRT2, IC50: 0.25 μM
        98.50%
Tenovin-1
Sirtuin
            99.88%
SirReal2    
SIRT2, IC50: 140 nM
        99.12%
Inauhzin  
SIRT1
          99.49%
AK-1    
SIRT2, IC50: 12.5 μM
        99.81%
Agrimol B  
SIRT1
          99.75%
Salermide  
SIRT1
SIRT2
        ≥98.0%
Sirt2-IN-1    
SIRT2, IC50: 163 nM
        98.45%
SIRT-IN-2  
SIRT1, IC50: 4 μM
SIRT2, IC50: 1 μM
SIRT3, IC50: 7 μM
      98.56%
Dihydrocoumarin  
hSIRT1, IC50: 208 μM
hSIRT2, IC50: 295 μM
        99.81%
Tenovin-6 Hydrochloride  
SIRT1, IC50: 21 μM
SIRT2, IC50: 10 μM
SIRT3, IC50: 67 μM
      ≥98.0%
Sirtuin modulator 1  
SIRT1, EC1.5: 1 μM
          99.72%
Et-29          
SIRT5, Ki: 40 nM
  99.89%
(S)-Selisistat  
SIRT1, IC50: 98 nM
          98.15%
Scopolin  
SIRT1
          99.46%
SIRT1-IN-1  
SIRT1, IC50: 0.205 μM
SIRT2, IC50: 11.5 μM
SIRT3, IC50: >100 μM
      98.01%
Suramin  
SIRT1, IC50: 297 nM
SIRT2, IC50: 1.15 μM
   
SIRT5, IC50: 22 μM
 
Nicotinamide riboside  
SIRT1
 
SIRT3
     
YK-3-237  
SIRT1
          99.59%
Ophiopogonin D'  
SIRT1
          99.85%
CHIC35  
SIRT1, IC50: 0.124 μM
SIRT2, IC50: 2.8 μM
SIRT3, IC50: >100 μM
     
Sirt2-IN-5    
SIRT2
       
3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol  
SIRT1
         
Ainsliadimer C  
SIRT1
         
Sirt2-IN-6    
SIRT2, IC50: 0.815 μM
       
Nicotinamide Hydrochloride    
SIRT2, EC50: 2 μM
       
SIRT5 inhibitor 3          
SIRT5, IC50: 5.9 μM
 
SIRT-IN-1  
SIRT1, IC50: 15 nM
SIRT2, IC50: 10 nM
SIRT3, IC50: 33 nM
      98.58%
MIND4-19    
SIRT2, IC50: 7.0 μM
        99.94%
SIRT5 inhibitor 4  
SIRT1, IC50: >400 μM
SIRT2, IC50: >400 μM
SIRT3, IC50: >400 μM
SIRT6, IC50: >400 μM
SIRT5, IC50: 26.4 μM
SIRT7, IC50: >400 μM
Nicotinamide riboside tartrate  
SIRT1
 
SIRT3
     
Sirt1/2-IN-1  
SIRT1, IC50: 1.81 μg/mL
SIRT2, IC50: 2.10 μg/mL
SIRT3, IC50: 20.5 μg/mL
     
Sirtuin modulator 4  
SIRT1, EC50: 51-100 μM
         
Nicotinamide riboside malate  
SIRT1
 
SIRT3
     
SIRT5 inhibitor 2          
SIRT5, IC50: 2.3 μM
 
Sirtuin modulator 5  
SIRT1, DC50: <50 μM
         
SIRT2-IN-9  
SIRT1, IC50: >300 μM
SIRT2, IC50: 1.3 μM
SIRT3, IC50: >300 μM
      99.45%
SIRT1-IN-3  
SIRT1, IC50: 4.2 μM
SIRT2, IC50: 38 μM
       
JGB1741  
SIRT1, IC50: ∼15 μM
SIRT2, IC50: >100 μM
SIRT3, IC50: >100 μM