3061491-60-6
Chemical Structure
SIRT3 activator 2
- CAS No.: 3061491-60-6
- Formula:C22H24N2O9S
- Molecular Weight:492.50
InChIKey: FDQMGLAVDNTTTR-UHFFFAOYSA-N
SMILES: CC(CC1(C(N2CCC3=O)=O)CC2=O)(C(N1S(C4=CC(C(OCCCO3)=O)=CC=C4)(=O)=O)=O)C
Biological Activity: SIRT3 activator 2 (compound 2a) is a SIRT3 activator. SIRT3 activator 2 improved the thermal stability of SIRT3 in SH-SY5Y cells, indicating that it can directly bind to SIRT3, has SIRT3 dependency in SH-SY5Y to clear α-Syn. SIRT3 activator 2 improves motor function in Parkinson mice, preventing Parkinson (DA) neuron loss in the substantia nigra in a dose-dependent manner[1].
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SIRT3 activator 2 | 98.94% | SIRT3 activator 2 (compound 2a) is a SIRT3 activator. SIRT3 activator 2 improved the thermal stability of SIRT3 in SH-SY5Y cells, indicating that it can directly bind to SIRT3, has SIRT3 dependency in SH-SY5Y to clear α-Syn. SIRT3 activator 2 improves motor function in Parkinson mice, preventing Parkinson (DA) neuron loss in the substantia nigra in a dose-dependent manner. | ||||||||||||||||||||
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Keywords
