SIRT3 activator 2
Based on 1 publication(s) in Google Scholar
SIRT3 activator 2 (compound 2a) is a SIRT3 activator. SIRT3 activator 2 improved the thermal stability of SIRT3 in SH-SY5Y cells, indicating that it can directly bind to SIRT3, has SIRT3 dependency in SH-SY5Y to clear α-Syn. SIRT3 activator 2 improves motor function in Parkinson mice, preventing Parkinson (DA) neuron loss in the substantia nigra in a dose-dependent manner.
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- Pureté : 98.94%
- CAS No.: 3061491-60-6
- Formule: C22H24N2O9S
- Masse moléculaire:492.50
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Stockage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) SIRT3 activator 2
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Activité biologique
Description
IC50 & Target
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SIRT3 |
In Vitro
SIRT3 activator 2 (10 μM, 100 μM) is a SIRT3 activator[1].
SIRT3 activator2 (10 μM; 24 h) enhances the thermal stability (CETSA) of SIRT3 in SH-SY5Y cells, indicating can bind directly to SIRT3 (WB) [1].
SIRT3 activator 2 (10 μM; 24 h) by SIRT3 dependency in SH-SY5Y cells, eliminats α-Syn (WB) to protects neurons.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SH-SY5Y
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Concentration:10 μM
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Incubation Time:24 h
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Result:Improved the thermal stability (CETSA) of SIRT3 in SH-SY5Y cells and could bind directly to SIRT3.
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Cell Line:Ttransfected with SIRT3 siRNAs in SH-SY5Y cells.
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Concentration:10 μM
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Incubation Time:24 h
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Result:Showed that the protective effect of SIRT3 activator 2 on MPP+ (600 μM) or 6-OHDA(100μM)-induced neuronal injury disappeared and the expression level of α-Syn did not change significantly after SIRT3 silences.
In Vivo
SIRT3 activator 2 (10, 20, 40 mg/kg; Intracerebroventricular injection (ICV)) dose-dependently prevents overexpression of A53T α-synuclein-induced loss of substantia nigra DA neurons (immunohistochemistry) [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Parkinson mouse model injected with overexpression of A53T α-synuclein[1]
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Dosage:10, 20, 40 mg/kg
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Administration:Intravenous injection (i.v.)；Once daily; 24 days;The viruses (2.5 x 1012 genomic particles/ml) were infused to the right substantia nigra of mouse
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Result:Showed that the movement function of mice was improved by increasing the walking distance, decreasing the descending time on the rod and increasing the descending time on the rotating rod.
Chemical Information
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CAS No. 3061491-60-6
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Appearance Solid
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Masse moléculaire 492.50
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Formule C22H24N2O9S
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Color White to off-white
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SMILES
CC(CC1(C(N2CCC3=O)=O)CC2=O)(C(N1S(C4=CC(C(OCCCO3)=O)=CC=C4)(=O)=O)=O)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Adv Sci (Weinh)
Cigarette Smoke-Induced Alveolar Macrophage Senescence via GEM/SIRT3-Mediated Mitochondrial Dysfunction. [Abstract]2026 Jun 22:e22788. PMID: 42325089
Solvant et solubilité
In Vitro:
DMSO : 4.93 mg/mL (10.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (287 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.0305 mL | 10.1523 mL | 20.3046 mL | 50.7614 mL |
| 5 mM | 0.4061 mL | 2.0305 mL | 4.0609 mL | 10.1523 mL | |
| 10 mM | 0.2030 mL | 1.0152 mL | 2.0305 mL | 5.0761 mL |
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