1. Cell Cycle/DNA Damage
    Epigenetics
    Anti-infection
  2. Sirtuin
    CMV
  3. SIRT1-IN-1

SIRT1-IN-1 

Cat. No.: HY-136199
Handling Instructions

SIRT1-IN-1 is a selective SIRT1 inhibitor with an IC50 of 0.205 μM. SIRT1-IN-1 inhibits SIRT2 with an IC50 of 11.5 μM. SIRT1-IN-1, a indole, is a cytomegalovirus (CMV) inhibitors and has antiviral activity.

For research use only. We do not sell to patients.

SIRT1-IN-1 Chemical Structure

SIRT1-IN-1 Chemical Structure

CAS No. : 352554-02-0

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Description

SIRT1-IN-1 is a selective SIRT1 inhibitor with an IC50 of 0.205 μM. SIRT1-IN-1 inhibits SIRT2 with an IC50 of 11.5 μM[1]. SIRT1-IN-1, a indole, is a cytomegalovirus (CMV) inhibitors and has antiviral activity[2].

IC50 & Target[1]

SIRT1

0.205 μM (IC50)

SIRT2

11.5 μM (IC50)

SIRT3

>100 μM (IC50)

In Vitro

SIRT1-IN-1 (compound 2) has little effect on SIRT3 (IC50>100 μM) and HDAC (IC50>100 μM)[1].

Molecular Weight

228.29

Formula

C₁₄H₁₆N₂O

CAS No.

352554-02-0

SMILES

O=C(C1C(NC2=C3C=C(C)C=C2)=C3CCC1)N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (438.04 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.3804 mL 21.9020 mL 43.8039 mL
5 mM 0.8761 mL 4.3804 mL 8.7608 mL
10 mM 0.4380 mL 2.1902 mL 4.3804 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 5 mg/mL (21.90 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 5 mg/mL (21.90 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

SIRT1-IN-1SirtuinCMVCytomegalovirusindolecytomegalovirusantiviralInhibitorinhibitorinhibit

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Product name:
SIRT1-IN-1
Cat. No.:
HY-136199
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