1011301-29-3
Chemical Structure
Tenovin-6 Hydrochloride
- CAS 番号: 1011301-29-3
- Formula:C25H35ClN4O2S
- Molecular Weight:491.09
IUPAC Name: 4-(tert-butyl)-N-((4-(5-(dimethylamino)pentanamido)phenyl)carbamothioyl)benzamide hydrochloride
InChIKey: UBNCTIDXQDCEPI-UHFFFAOYSA-N
SMILES: O=C(NC(NC1=CC=C(NC(CCCCN(C)C)=O)C=C1)=S)C2=CC=C(C(C)(C)C)C=C2.Cl
Biological Activity: Tenovin-6 Hydrochloride, an analog of Tenovin-1 (HY-13423), is an activator of p53 transcriptional activity. Tenovin-6 Hydrochloride inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 with IC50s of 21 μM, 10 μM, and 67 μM, respectively. Tenovin-6 Hydrochloride also inhibits dihydroorotate dehydrogenase (DHODH)[1][2].
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Tenovin-6 Hydrochloride | 99.17% | Tenovin-6 Hydrochloride, an analog of Tenovin-1 (HY-13423), is an activator of p53 transcriptional activity. Tenovin-6 Hydrochloride inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 with IC50s of 21 μM, 10 μM, and 67 μM, respectively. Tenovin-6 Hydrochloride also inhibits dihydroorotate dehydrogenase (DHODH). | ||||||||||||||||||||
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-
Similarity Score 0.99
HY-15510Tenovin-6 -
Similarity Score 0.82
HY-182976Tenovin-3-CO-C9-NH2 -
Similarity Score 0.79
HY-13423Tenovin-1 -
Similarity Score 0.79
HY-114198Tenovin-2 -
Similarity Score 0.72
HY-123994Tenovin-D3 hydrochloride -
Similarity Score 0.71
HY-19339Tenovin-3 -
Similarity Score 0.69
HY-155110Antiviral agent 34 -
Similarity Score 0.61
HY-163659Anti-Influenza agent 6 -
Similarity Score 0.58
HY-138831AES-350 -
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References
- [1]. Lain S, et al. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell. 2008 May;13(5):454-63. [Content Brief]
- [2]. Ladds MJGW, et al. Exploitation of DHODH and p53 activation as therapeutic targets - a case study in polypharmacology [published online ahead of print, 2020 Sep 8]. J Biol Chem. 2020;jbc.RA119.012056. [Content Brief]
