1. Apoptosis
  2. MDM-2/p53
  3. Tenovin-3

Tenovin-3 

Cat. No.: HY-19339 Purity: 99.71%
Handling Instructions

Tenovin-3 is able to increase p53 levels, determined in MCF-7 cells treated for 6 hr at 10 μM.

For research use only. We do not sell to patients.

Tenovin-3 Chemical Structure

Tenovin-3 Chemical Structure

CAS No. : 1011301-27-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 130 In-stock
Estimated Time of Arrival: December 31
1 mg USD 84 In-stock
Estimated Time of Arrival: December 31
5 mg USD 180 In-stock
Estimated Time of Arrival: December 31
10 mg USD 312 In-stock
Estimated Time of Arrival: December 31
25 mg USD 660 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1128 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
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Description

Tenovin-3 is able to increase p53 levels, determined in MCF-7 cells treated for 6 hr at 10 μM. Target: p53 in vitro: Tenovins inhibit the activities of human SirT1 and SirT2, two members of the NAD+-dependent class III histone deacetylases that also belong to the sirtuin family.[1]

Molecular Weight

327.44

Formula

C₁₈H₂₁N₃OS

CAS No.

1011301-27-1

SMILES

O=C(NC(NC1=CC=C(N)C=C1)=S)C2=CC=C(C(C)(C)C)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 31 mg/mL (94.67 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0540 mL 15.2700 mL 30.5399 mL
5 mM 0.6108 mL 3.0540 mL 6.1080 mL
10 mM 0.3054 mL 1.5270 mL 3.0540 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.63 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.63 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Tenovin-3Tenovin3Tenovin 3MDM-2/p53Inhibitorinhibitorinhibit

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Product name:
Tenovin-3
Cat. No.:
HY-19339
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