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Cat. No.: HY-163659

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Anti-Influenza agent 6

Anti-Influenza agent 6 (compound 19b) shows inhibitory activity against A/WSN/33/H1N1 (EC₅₀ = 0.015 μM) and influenza B virus Yamagata/16/88 (EC₅₀ = 0.073 μM) and Victotis/2/87 (EC₅₀ = 0.067 μM).

For research use only. We do not sell to patients.

CAS No.: 2917502-08-8
Formula: C₄₂H₆₄N₆O₇S
Molecular Weight:797.06

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

Anti-Influenza agent 6 Chemical Structure

CAS No.: 2917502-08-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HEK-293T	CC₅₀	>100 μM Compound: 19b	Cytotoxicity against human HEK293T cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay Cytotoxicity against human HEK293T cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay	[PMID: 38775356]
HEK-293T	EC₅₀	0.015 μM Compound: 19b	Anti-influenza activity against Influenza A virus A/WSN/33(H1N1) infected in HEK293T cells assessed as reduction in virus-induced cytopathic effect incubated for 48 hrs by CCK-8 assay Anti-influenza activity against Influenza A virus A/WSN/33(H1N1) infected in HEK293T cells assessed as reduction in virus-induced cytopathic effect incubated for 48 hrs by CCK-8 assay	[PMID: 38775356]
HEK-293T	EC₅₀	0.036 μM Compound: 19b	Anti-influenza activity against Influenza A virus H3N2 infected in HEK293T cells assessed as reduction in virus-induced cytopathic effect incubated for 48 hrs by CCK-8 assay Anti-influenza activity against Influenza A virus H3N2 infected in HEK293T cells assessed as reduction in virus-induced cytopathic effect incubated for 48 hrs by CCK-8 assay	[PMID: 38775356]
HEK-293T	EC₅₀	0.067 μM Compound: 19b	Anti-influenza activity against Influenza B virus Victoria/2/87 infected in HEK293T cells assessed as reduction in virus-induced cytopathic effect incubated for 48 hrs by CCK-8 assay Anti-influenza activity against Influenza B virus Victoria/2/87 infected in HEK293T cells assessed as reduction in virus-induced cytopathic effect incubated for 48 hrs by CCK-8 assay	[PMID: 38775356]
HEK-293T	EC₅₀	0.073 μM Compound: 19b	Anti-influenza activity against Influenza B virus Yamagata/16/88 infected in HEK293T cells assessed as reduction in virus-induced cytopathic effect incubated for 48 hrs by CCK-8 assay Anti-influenza activity against Influenza B virus Yamagata/16/88 infected in HEK293T cells assessed as reduction in virus-induced cytopathic effect incubated for 48 hrs by CCK-8 assay	[PMID: 38775356]
MDCK	CC₅₀	>200 μM Compound: 19b	Cytotoxicity against dog MDCK cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay Cytotoxicity against dog MDCK cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay	[PMID: 38775356]

Chemical Information

CAS No. 2917502-08-8
Molecular Weight 797.06
Formula C₄₂H₆₄N₆O₇S
SMILES

CC(C)(C)OC(N[C@@H](CCCCNC(OC(C)(C)C)=O)C(NCCCCCCCC(NC(C=C1)=CC=C1NC(NC(C2=CC=C(C=C2)C(C)(C)C)=O)=S)=O)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Xiaoyu Ma, et al. Novel Acyl Thiourea-Based Hydrophobic Tagging Degraders Exert Potent Anti-Influenza Activity through Two Distinct Endonuclease Polymerase Acidic-Targeted Degradation Pathways. J Med Chem. 2024 Jun 13;67(11):8791-8816. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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