Anti-Influenza agent 6

Cat. No.: HY-163659: Ficha de datos Instrucciones de manejo
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Anti-Influenza agent 6 (compound 19b) shows inhibitory activity against A/WSN/33/H1N1 (EC₅₀ = 0.015 μM) and influenza B virus Yamagata/16/88 (EC₅₀ = 0.073 μM) and Victotis/2/87 (EC₅₀ = 0.067 μM).

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Anti-Influenza agent 6 Estructura química

No. CAS : 2917502-08-8

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Descripciòn

Cellular Effect

Cell Line	Type	Value	Description	References
HEK-293T	CC₅₀	>100 μM Compound: 19b	Cytotoxicity against human HEK293T cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay Cytotoxicity against human HEK293T cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay	[PMID: 38775356]
HEK-293T	EC₅₀	0.015 μM Compound: 19b	Anti-influenza activity against Influenza A virus A/WSN/33(H1N1) infected in HEK293T cells assessed as reduction in virus-induced cytopathic effect incubated for 48 hrs by CCK-8 assay Anti-influenza activity against Influenza A virus A/WSN/33(H1N1) infected in HEK293T cells assessed as reduction in virus-induced cytopathic effect incubated for 48 hrs by CCK-8 assay	[PMID: 38775356]
HEK-293T	EC₅₀	0.036 μM Compound: 19b	Anti-influenza activity against Influenza A virus H3N2 infected in HEK293T cells assessed as reduction in virus-induced cytopathic effect incubated for 48 hrs by CCK-8 assay Anti-influenza activity against Influenza A virus H3N2 infected in HEK293T cells assessed as reduction in virus-induced cytopathic effect incubated for 48 hrs by CCK-8 assay	[PMID: 38775356]
HEK-293T	EC₅₀	0.067 μM Compound: 19b	Anti-influenza activity against Influenza B virus Victoria/2/87 infected in HEK293T cells assessed as reduction in virus-induced cytopathic effect incubated for 48 hrs by CCK-8 assay Anti-influenza activity against Influenza B virus Victoria/2/87 infected in HEK293T cells assessed as reduction in virus-induced cytopathic effect incubated for 48 hrs by CCK-8 assay	[PMID: 38775356]
HEK-293T	EC₅₀	0.073 μM Compound: 19b	Anti-influenza activity against Influenza B virus Yamagata/16/88 infected in HEK293T cells assessed as reduction in virus-induced cytopathic effect incubated for 48 hrs by CCK-8 assay Anti-influenza activity against Influenza B virus Yamagata/16/88 infected in HEK293T cells assessed as reduction in virus-induced cytopathic effect incubated for 48 hrs by CCK-8 assay	[PMID: 38775356]
MDCK	CC₅₀	>200 μM Compound: 19b	Cytotoxicity against dog MDCK cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay Cytotoxicity against dog MDCK cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay	[PMID: 38775356]

Peso molecular

797.06

Fòrmula

C₄₂H₆₄N₆O₇S

No. CAS

2917502-08-8

SMILES

CC(C)(C)OC(N[C@@H](CCCCNC(OC(C)(C)C)=O)C(NCCCCCCCC(NC(C=C1)=CC=C1NC(NC(C2=CC=C(C=C2)C(C)(C)C)=O)=S)=O)=O)=O

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Xiaoyu Ma, et al. Novel Acyl Thiourea-Based Hydrophobic Tagging Degraders Exert Potent Anti-Influenza Activity through Two Distinct Endonuclease Polymerase Acidic-Targeted Degradation Pathways. J Med Chem. 2024 Jun 13;67(11):8791-8816. [Content Brief]