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Art. -Nr.: HY-155110

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Antiviral agent 34

Name: Antiviral agent 34
Brand: MedChemExpress
SKU: HY-155110
Price: 358.00 USD
Availability: InStock
Rating: 5 (1 reviews)

Antiviral agent 34 is a potent and orally active antiviral agent against influenza A and B subtypes with an EC₅₀ value of 0.8 nM for H1N1 proliferation. Antiviral agent 34 derivatives inhibited influenza virus proliferation by targeting influenza virus RNA-dependent RNA polymerase. Antiviral agent 34 can be used for influenza virus research.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 945152-88-5
Formel: C₂₉H₃₃N₃O₂S
Molecular Weight:487.66

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Antiviral agent 34 Chemical Structure

CAS. Nr.: 945152-88-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

RNA Polymerase

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
MDCK	CC₅₀	>100 μM Compound: 10m	Cytotoxicity against MDCK cells by CCK-8 assay Cytotoxicity against MDCK cells by CCK-8 assay	[PMID: 37531746]

In Vitro

Antiviral agent 34 (Compound 10m) (0-470 nM, 24 h) demonstrates a high safety profile and inhibits the H1N1 virus proliferation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

MDCK cells
Concentration:

0-470 nM
Incubation Time:

24 h
Result:

Exhibited low toxicity to MDCK cells.

Western Blot Analysis^[1]

Cell Line:

MDCK cells
Concentration:

2-125 nM
Incubation Time:

24 h
Result:

Reduced the protein level of H1N1 nucleocapsid protein (NP) with low nanomolar values.

Real Time qPCR^[1]

Cell Line:

MDCK cells
Concentration:

2-31.3 nM
Incubation Time:

24 h
Result:

Reduced the mRNA level of H1N1 nucleocapsid protein (NP) with low nanomolar values.

In Vivo

Antiviral agent 34 (Compound 10m) (1 g/kg for orally administration, three times a day and continues for 14 days) exhibits antiviral activity in a lethal influenza virus mouse model^[1].

Pharmacokinetic Analysis in SD rats ^[1]

Route	Dose (mg/kg)	AUC_last (ng•h/mL)	AUC_{INF_obs} (ng•h/mL)	t_1/2 (h)	T_max (h)	C_max (ng/mL)	Cl_obs (L•h/kg)	V_{ss_obs} (mL/kg)	MRT_{INF_obs} (h)	F (%)
i.v.	3	21944	21920	3.69	0.08	41942	2.29	/	/	/
p.o.	10	5416	5395	3.26	4.0d	1184	/	/	/	7.38

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c mice ^[1]
Dosage:

1 g/kg/d continues for 14 days
Administration:

Oral gavage (p.o.)
Result:

Tolerated at a dose of 1 g/kg with low acute toxicity.
Provided ~ 50% protection in mice infected with lethal-dose H1N1.

Animal Model:

SD rats (Pharmacokinetic assay)^[1]
Dosage:

3 mg/kg, 10 mg/kg
Administration:

intravenous injection (i.v.), oral administration (p.o.)
Result:

Had preferable AUC value and low clearance rate and displayed superior oral bioavailability (F = 7.38%).

Chemical Information

CAS. Nr. 945152-88-5
Molecular Weight 487.66
Formel C₂₉H₃₃N₃O₂S
SMILES

CC(C)(C)C1=CC=C(C(NC(NC2=CC=C(NC(C3=CC=C(C(C)(C)C)C=C3)=O)C=C2)=S)=O)C=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Liu X, et al. Rational design and optimization of acylthioureas as novel potent influenza virus non-nucleoside polymerase inhibitors. Eur J Med Chem. 2023 Nov 5;259:115678. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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