2. Anti-infection
  3. Influenza Virus
  4. Antiviral agent 34

Antiviral agent 34 is a potent and orally active antiviral agent against influenza A and B subtypes with an EC50 value of 0.8 nM for H1N1 proliferation. Antiviral agent 34 derivatives inhibited influenza virus proliferation by targeting influenza virus RNA-dependent RNA polymerase. Antiviral agent 34 can be used for influenza virus research.

For research use only. We do not sell to patients.

Antiviral agent 34 Chemical Structure

Antiviral agent 34 Chemical Structure

CAS No. : 945152-88-5

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Antiviral agent 34 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Antiviral agent 34 is a potent and orally active antiviral agent against influenza A and B subtypes with an EC50 value of 0.8 nM for H1N1 proliferation. Antiviral agent 34 derivatives inhibited influenza virus proliferation by targeting influenza virus RNA-dependent RNA polymerase. Antiviral agent 34 can be used for influenza virus research[1].

In Vitro

Antiviral agent 34 (Compound 10m) (0-470 nM, 24 h) demonstrates a high safety profile and inhibits the H1N1 virus proliferation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antiviral agent 34 Related Antibodies

Cell Viability Assay[1]

Cell Line: MDCK cells
Concentration: 0-470 nM
Incubation Time: 24 h
Result: Exhibited low toxicity to MDCK cells.

Western Blot Analysis[1]

Cell Line: MDCK cells
Concentration: 2-125 nM
Incubation Time: 24 h
Result: Reduced the protein level of H1N1 nucleocapsid protein (NP) with low nanomolar values.

Real Time qPCR[1]

Cell Line: MDCK cells
Concentration: 2-31.3 nM
Incubation Time: 24 h
Result: Reduced the mRNA level of H1N1 nucleocapsid protein (NP) with low nanomolar values.
In Vivo

Antiviral agent 34 (Compound 10m) (1 g/kg for orally administration, three times a day and continues for 14 days) exhibits antiviral activity in a lethal influenza virus mouse model[1].

Pharmacokinetic Analysis in SD rats [1]

Route Dose (mg/kg) AUClast (ng•h/mL) AUCINF_obs (ng•h/mL) t1/2 (h) Tmax (h) Cmax (ng/mL) Clobs (L•h/kg) Vss_obs (mL/kg) MRTINF_obs (h) F (%)
i.v. 3 21944 21920 3.69 0.08 41942 2.29 / / /
p.o. 10 5416 5395 3.26 4.0d 1184 / / / 7.38

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice [1]
Dosage: 1 g/kg/d continues for 14 days
Administration: Oral gavage (p.o.)
Result: Tolerated at a dose of 1 g/kg with low acute toxicity.
Provided ~ 50% protection in mice infected with lethal-dose H1N1.
Animal Model: SD rats (Pharmacokinetic assay)[1]
Dosage: 3 mg/kg, 10 mg/kg
Administration: intravenous injection (i.v.), oral administration (p.o.)
Result: Had preferable AUC value and low clearance rate and displayed superior oral bioavailability (F = 7.38%).
Molecular Weight

487.66

Formula

C29H33N3O2S
CAS No.
SMILES

CC(C)(C)C1=CC=C(C(NC(NC2=CC=C(NC(C3=CC=C(C(C)(C)C)C=C3)=O)C=C2)=S)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Antiviral agent 34 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antiviral agent 34945152-88-5Antiviral agent34Antiviral agent-34Influenza Virusinfluenza virusRNA-dependent RNA polymerasenon-nucleoside polymerase inhibitorsdruggability evaluationInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Antiviral agent 34
Cat. No.:
HY-155110
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.