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Cat. No.: HY-155110

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Antiviral agent 34

Antiviral agent 34 is a potent and orally active antiviral agent against influenza A and B subtypes with an EC₅₀ value of 0.8 nM for H1N1 proliferation. Antiviral agent 34 derivatives inhibited influenza virus proliferation by targeting influenza virus RNA-dependent RNA polymerase. Antiviral agent 34 can be used for influenza virus research.

For research use only. We do not sell to patients.

CAS No.: 945152-88-5
Formula: C₂₉H₃₃N₃O₂S
Molecular Weight:487.66

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Antiviral agent 34 Chemical Structure

CAS No.: 945152-88-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

RNA Polymerase

All DNA/RNA Synthesis Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MDCK	CC₅₀	>100 μM Compound: 10m	Cytotoxicity against MDCK cells by CCK-8 assay Cytotoxicity against MDCK cells by CCK-8 assay	[PMID: 37531746]

In Vitro

Antiviral agent 34 (Compound 10m) (0-470 nM, 24 h) demonstrates a high safety profile and inhibits the H1N1 virus proliferation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

MDCK cells
Concentration:

0-470 nM
Incubation Time:

24 h
Result:

Exhibited low toxicity to MDCK cells.

Western Blot Analysis^[1]

Cell Line:

MDCK cells
Concentration:

2-125 nM
Incubation Time:

24 h
Result:

Reduced the protein level of H1N1 nucleocapsid protein (NP) with low nanomolar values.

Real Time qPCR^[1]

Cell Line:

MDCK cells
Concentration:

2-31.3 nM
Incubation Time:

24 h
Result:

Reduced the mRNA level of H1N1 nucleocapsid protein (NP) with low nanomolar values.

In Vivo

Antiviral agent 34 (Compound 10m) (1 g/kg for orally administration, three times a day and continues for 14 days) exhibits antiviral activity in a lethal influenza virus mouse model^[1].

Pharmacokinetic Analysis in SD rats ^[1]

Route	Dose (mg/kg)	AUC_last (ng•h/mL)	AUC_{INF_obs} (ng•h/mL)	t_1/2 (h)	T_max (h)	C_max (ng/mL)	Cl_obs (L•h/kg)	V_{ss_obs} (mL/kg)	MRT_{INF_obs} (h)	F (%)
i.v.	3	21944	21920	3.69	0.08	41942	2.29	/	/	/
p.o.	10	5416	5395	3.26	4.0d	1184	/	/	/	7.38

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c mice ^[1]
Dosage:

1 g/kg/d continues for 14 days
Administration:

Oral gavage (p.o.)
Result:

Tolerated at a dose of 1 g/kg with low acute toxicity.
Provided ~ 50% protection in mice infected with lethal-dose H1N1.

Animal Model:

SD rats (Pharmacokinetic assay)^[1]
Dosage:

3 mg/kg, 10 mg/kg
Administration:

intravenous injection (i.v.), oral administration (p.o.)
Result:

Had preferable AUC value and low clearance rate and displayed superior oral bioavailability (F = 7.38%).

Chemical Information

CAS No. 945152-88-5
Molecular Weight 487.66
Formula C₂₉H₃₃N₃O₂S
SMILES

CC(C)(C)C1=CC=C(C(NC(NC2=CC=C(NC(C3=CC=C(C(C)(C)C)C=C3)=O)C=C2)=S)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Liu X, et al. Rational design and optimization of acylthioureas as novel potent influenza virus non-nucleoside polymerase inhibitors. Eur J Med Chem. 2023 Nov 5;259:115678. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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Antiviral agent 34

All DNA/RNA Synthesis Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Antiviral agent 34 Related Classifications

HY-155110 Related Classifications