Ac-QPKK(Ac)-AMC acetate
Based on 1 Customer Validation
Ac-QPKK(Ac)-AMC acetate is a p53-derived peptide conjugated with a fluorophore, which serves as a fluorescent peptide substrate for detecting the deacylase activity of zinc-dependent HDACs and sirtuins (Ex = 360 nm; Em = 460 nm).
For research use only. We do not sell to patients.
- Purity: 99.38%
- Formula: C36H52N8O9·xC2H4O2
- Molecular Weight:740.85 (free base)
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Storage:
Sealed storage, away from moisture and light.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
|
hHDAC1 |
hHDAC2 |
hHDAC3 |
SIRT1 |
SIRT2 |
SIRT3 |
SIRT6 |
Ac-QPKK(Ac)-AMC (4a) (50 μM; 60 min) acetate is acted upon by recombinant human HDAC1, HDAC2, and HDAC3/NCoR2 which exhibit potent deacetylase activity toward the peptide substrate in vitro, with HDAC3/NCoR2 being the most potent[1].
Ac-QPKK(Ac)-AMC (2a) acetate is deacetylated by recombinant SIRT1, SIRT2 and SIRT3 in vitro with distinct catalytic efficiencies, whereas SIRT6 shows negligible deacetylase activity toward this substrate[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 740.85 (free base)
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Formula C36H52N8O9·xC2H4O2
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Color White to off-white
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Sequence
Ac-Gln-Pro-Lys-{Lys(Ac)}-AMC
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Sequence Shortening
Ac-QPK-{Lys(Ac)}-AMC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture and light
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 10 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ac-QPKK(Ac)-AMC acetate Related Classifications
HY-P3364A Related Classifications
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