Ac-QPKK(Ac)-AMC
Ac-QPKK(Ac)-AMC is a p53-derived peptide conjugated with a fluorophore, which serves as a fluorescent peptide substrate for detecting the deacylase activity of zinc-dependent HDACs and sirtuins (Ex = 360 nm; Em = 460 nm).
For research use only. We do not sell to patients.
- CAS No.: 1387005-23-3
- Formula: C36H52N8O9
- Molecular Weight:740.85
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Ac-QPKK(Ac)-AMC (4a) (50 μM; 60 min) is acted upon by recombinant human HDAC1, HDAC2, and HDAC3/NCoR2 which exhibit potent deacetylase activity toward the peptide substrate in vitro, with HDAC3/NCoR2 being the most potent[1].
Ac-QPKK(Ac)-AMC (2a) is deacetylated by recombinant SIRT1, SIRT2 and SIRT3 in vitro with distinct catalytic efficiencies, whereas SIRT6 shows negligible deacetylase activity toward this substrate[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1387005-23-3
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Molecular Weight 740.85
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Formula C36H52N8O9
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Sequence
Ac-Gln-Pro-Lys-{Lys(Ac)}-AMC
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Sequence Shortening
Ac-QPK-{Lys(Ac)}-AMC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ac-QPKK(Ac)-AMC Related Classifications
HY-P3364 Related Classifications
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