1387005-23-3
1387005-23-3
Chemical Structure
Ac-QPKK(Ac)-AMC
- CAS No.: 1387005-23-3
- Formula:C36H52N8O9
- Molecular Weight:740.85
IUPAC Name: 3-(2-aminopropyl)-1H-indol-5-ol
InChIKey: LHVYYJGFOAKRPP-DZUOILHNSA-N
SMILES: CC(C1=CC=C(NC([C@H](CCCCNC(C)=O)NC([C@H](CCCCN)NC([C@H]2N(CCC2)C([C@@H](NC(C)=O)CCC(N)=O)=O)=O)=O)=O)C=C1O3)=CC3=O
Biological Activity: Ac-QPKK(Ac)-AMC is a p53-derived peptide conjugated with a fluorophore, which serves as a fluorescent peptide substrate for detecting the deacylase activity of zinc-dependent HDACs and sirtuins (Ex = 360 nm; Em = 460 nm)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Ac-QPKK(Ac)-AMC | Ac-QPKK(Ac)-AMC is a p53-derived peptide conjugated with a fluorophore, which serves as a fluorescent peptide substrate for detecting the deacylase activity of zinc-dependent HDACs and sirtuins (Ex = 360 nm; Em = 460 nm). | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Moreno-Yruela C, et al. Class I histone deacetylases (HDAC1–3) are histone lysine delactylases. Sci Adv. 2022 Jan 19;8(3):eabi6696.
- [2]. Galleano I, et al. A Continuous, Fluorogenic Sirtuin 2 Deacylase Assay: Substrate Screening and Inhibitor Evaluation. J Med Chem. 2016 Feb 11;59(3):1021-31. [Content Brief]
Keywords
